Formalin-induced increase in p2x3 receptor expression in dorsal root ganglia: Implications for nociception

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 8, 2009, Pages

  Pan, Ai Hua ^a   Lu, Da Hua ^a   Luo, Xue Gang ^a   Chen, Ling ^b   Li, Zhi Yuan ^a,b  

^a Central South University   (China)

^b GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

Author keywords

Dorsal root ganglia; P2X3 receptor; Spinal cord

Indexed keywords

ADENOSINE TRIPHOSPHATE; FORMALDEHYDE; GLUTAMATE SYNTHASE; MONOMER; PURINERGIC P2X3 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL ISOLATION; CELL MEMBRANE; CONTROLLED STUDY; FEMALE; HINDLIMB; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; LUMBAR SPINAL CORD; MALE; MEMBRANE CURRENT; MOLECULAR MODEL; NERVE CELL; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN RECEPTOR; PATCH CLAMP; RAT; RECEPTOR UPREGULATION; SENSORY NERVE; SPINAL GANGLION; WESTERN BLOTTING; WHOLE CELL;

ACTION POTENTIALS; ANIMALS; BLOTTING, WESTERN; FEMALE; FORMALDEHYDE; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, FLUORESCENCE; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2;

EID: 68549140158     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05179.x     Document Type: Article

References (28)

1. Koles L, Furst S, Illes P. Purine ionotropic (P2X) receptors. Curr. Pharm. Des. 2007 13 : 2368 84.
2. Hamilton SG, McMahon SB. ATP as a peripheral mediator of pain. J. Auton. Nerv. Syst. 2000 81 : 187 94.
3. Burnstock G. P2X receptors in sensory neurons. Br. J. Anaesth. 2000 84 : 476 88.
4. North RA. Molecular physiology of P2X receptors. Physiol. Rev. 2002 82 : 1013 67.
5. Gu JG. P2X receptor-mediated modulation of sensory transmission to the spinal cord dorsal horn. Neuroscientist 2003 9 : 370 8.
6. Engelman HS, MacDermott AB. Presynaptic ionotropic receptors and control of transmitter release. Nat. Rev. Neurosci. 2004 5 : 135 45.
7. Ji RR, Woolf CG. Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain. Neurobiol. Dis. 2001 8 : 1 10.
8. Obata K, Noguchi K. MAPK activation in nociceptive neurons and pain hypersensitivity. Life Sci. 2004 74 : 2643 53.
9. 3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 1995 377 : 432 5.
10. 3 is expressed by DRG neurons that terminate in inner lamina II. Eur. J. Neurosci. 1998 10 : 3470 8.
11. 3 knock-out mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 2001 21 : 5670 7.
12. Tjølsen A, Berge O, Hunskaar S, Rosland JH, Hole K. The formalin test: An evaluation of the method. Pain 1992 51 : 5 17.
13. Shibata M, Ohkubo T, Takahashi H, Inoki R. Modified formalin test: Characteristic biphasic pain response. Pain 1989 38 : 347 52.
14. 2 receptor. J. Neurosci. 2004 24 : 7378 86.
15. Pan A, Luo XG. Expression and localization of the inwardly rectifying potassium channel Kir2.1 in glia cells of native bovine retina. J. Central South Univ. Technol. 2005 12 : 350 5 (in Chinese with an English abstract).
16. Miller KE, Richards BA, Kriebel RM. Glutamine-, glutamine synthease-, glutamate dehydrogenase- and pyruvate carboxylase-immunoreactivities in the rat dorsal root ganglion and peripheral nerve. Brain Res. 2002 945 : 202 11.
17. 3 receptor expression and function following spinal nerve ligation in the rat. Exp. Brain Res. 2002 147 : 511 19.
18. Sugiura Y, Lee CL, Perl ER. Central projections of identified, unmyelinated (C) afferent fiber innervating mammalian skin. Science 1986 234 : 358 61.
19. 2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur. J. Pharmacol. 2004 504 : 45 53.
20. Puig S, Sorkin LS. Formalin-evoked activity in identical primary afferent fibers: Systemic lidocaine suppresses phase-2 activity. Pain 1996 64 : 345 55.
21. 3 purinoceptors in sensory neurons in naive rats and following neuropathic injury. Pain 1999 80 : 273 82.
22. Wang R, Guo W, Ossipov MH, Vanderah TW, Porreca F, Lai J. Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neuroscience 2003 121 : 815 24.
23. Kim C, Chung JM, Chung K. Changes in the gene expression of six subtypes of P2X receptors in rat dorsal root ganglion after spinal nerve ligation. Neurosci. Lett. 2003 337 : 81 4.
24. Fu KY, Light AR, Maixner W. Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw. J. Pain 2001 2 : 2 11.
25. Vierck CJ, Yezierski RP, Light AR. Long-lasting hyperalgesia and sympathetic dysregulation after formalin injection into the rat hind paw. Neuroscience 2008 153 : 501 6.
26. 4 receptor by lesional activated microglia during formalin-induced inflammatory pain. J. Neuroimmunol. 2005 163 : 120 7.
27. 2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors. Proc. Natl Acad. Sci. USA 2004 101 : 11 868 73.
28. Li Z, Liang D, Chen L. Potential therapeutic targets for ATP-gated P2X receptor ion channels. Assay Drug Dev. Technol. 2008 6 : 277 84.