The use of an endothelium-targeted cationic copolymer to enhance the barrier function of lung capillary endothelial monolayers

Biomaterials

Volumn 30, Issue 29, 2009, Pages 5885-5891

  Giantsos, Kristina M ^a   Kopeckova, Pavla ^a   Dull, Randal O ^a,b,c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c Department of Electrical and Computer Engineering   (United States)

Author keywords

Endothelial cell; Hydraulic conductivity; Mechanotransduction; Vascular inflammation

Indexed keywords

BARRIER FUNCTIONS; BIOMIMETIC POLYMERS; CAPILLARY BARRIERS; CARDIOPULMONARY BYPASS; CATIONIC COPOLYMER; DISEASE STATE; ENDOTHELIAL BARRIERS; MECHANOTRANSDUCTION; MICRO-VASCULATURE; ORGAN TRANSPLANTS; RESPIRATORY DISTRESS SYNDROME; VASCULAR INFLAMMATION; VASCULAR SURGERY;

BIOLOGICAL ORGANS; BIOMIMETICS; BLOOD VESSEL PROSTHESES; CAPILLARITY; CELL MEMBRANES; CHLORINE COMPOUNDS; COPOLYMERIZATION; COPOLYMERS; ENDOTHELIAL CELLS; ENZYME INHIBITION; FUNCTIONAL POLYMERS; HYDRAULIC CONDUCTIVITY; MONOLAYERS; PATHOLOGY; SIGNAL TRANSDUCTION; THERMOANALYSIS;

SELF ASSEMBLY;

ALBUMIN; COPOLYMER; GLYCOPROTEIN;

ANIMAL CELL; ARTICLE; CAPILLARY ENDOTHELIUM; CAPILLARY PERMEABILITY; CELL INTERACTION; CONTROLLED STUDY; COW; CYTOTOXICITY; GLYCOCALYX; HYDRAULIC CONDUCTIVITY; LUNG CAPILLARY; MECHANOTRANSDUCTION; MONOLAYER CULTURE; NONHUMAN; POROSITY; PRESSURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNTHESIS;

AMMONIUM CHLORIDE; ANIMALS; CAPILLARIES; CAPILLARY PERMEABILITY; CATIONS; CATTLE; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; LUNG; METHACRYLATES;

EID: 68549139871     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.06.048     Document Type: Article

References (17)

1. Vink H., and Duling B.R. Capillary endothelial surface layer selectively reduces plasma solute distribution volume. Am J Physiol Heart Circ Physiol 278 1 (2000) H285-H289
2. Pohl U., Herlan K., Huang A., and Bassenge E. EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries. Am J Physiol Heart Circ Physiol 261 6 (1991) H2016-H2023
3. Pahakis M.Y., Kosky J.R., Dull R.O., and Tarbell J.M. The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress. Biochem Biophys Res Commun 355 1 (2007) 228-233
4. Jacob M., Rehm M., Loetsch M., Paul J.O., Bruegger D., Welsch U., et al. The endothelial glycocalyx prefers albumin for evoking shear stress-induced nitric oxide-mediated coronary dilation. J Vasc Res 44 6 (2007) 435-443
5. Dull R., Mecham I., and McJames S. Heparan sulfates mediate pressure-induced increase in lung endothelial hydraulic conductivity via nitric oxide/reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 292 (2007) L1452-L1458
6. Davies P.F. Flow mediated endothelial mechanotransduction. Physiol Rev 75 3 (1995) 519-560
7. Helmke B.P., Thakker D.B., Goldman R.D., and Davies P.F. Spatiotemporal analysis of flow-induced intermediate filament displacement in living endothelial cells. Biophys J 80 (2001) 184-194
8. Florian J.A., Kosky J.R., Ainslie K., Pang Z., Dull R.O., and Tarbell J.M. Heparan sulfate proteoglycan is a mechanosensor on endothelial cells. Circ Res 93 10 (2003) e136-e142
9. Wei Z., Costa K., Al-Medhi A.B., Dodia C., Muzykantov V., and Fisher A.B. Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling. Circ Res 85 (1999) 682-689
10. Pan H., Kopeckova P., Wang D., Yang J., Miller S., and Kopecek J. Water-soluble HPMA copolymer-prostaglandin E1 conjugates containing a cathepsin K sensitive spacer. J Drug Target 14 6 (2006) 425-435
11. Fritz J.S., and Schenk G.H. Quantitative analytical chemistry. 5th ed. (1987), Prentice Hall, Englewood Cliffs, NJ
12. Samejima K., Dairman W., Stone J., and Udenfriend S. Condensation of ninhydrin with aldehydes and primary amines to yield highly fluorescent ternary products: II. Application to the detection and assay of peptides, amino acids, amines, and amino sugars. Anal Biochem 42 1 (1971) 237-247
13. Hubert C.G., McJames S.W., Mecham I., and Dull R.O. Digital Imaging system and virtual instrument platform for measuring hydraulic conductivity of vascular endothelial monolayers. Microvasc Res 71 (2006) 135-140
14. Luten J., Akeroyd N., Funhoff A., Lok M.C., Talsma H., and Hennik W.E. Methacrylamide polymers with hydrolysis-sensitive cationic side groups as degradable gene carriers. Bioconjug Chem 17 (2006) 1077-1084
15. Pvd W., Moret E.E., Shuurmans-Nieuwenbroek N.M.E., MJv S., and Hennik W.E. Structure-activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery. Bioconjug Chem 10 (1999) 589-597
16. Eldred S.E., Pancost M.R., Otte K.M., Rozema D., Stahl S.S., and Gellman S.H. Effects of side chain configuration and backbone spacing on the gene delivery properties of lysine-derived cationic polymers. Bioconjug Chem 16 (2005) 694-699
17. Reschel T., Konak C., Oupicky D., Seymour L., and Ulbrich K. Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations. J Control Release 81 1-2 (2002) 201-217