Cornering the fear engram: Long-term synaptic changes in the lateral nucleus of the amygdala after fear conditioning

Journal of Neuroscience

Volumn 29, Issue 31, 2009, Pages 9700-9703

  Kwon, Jeong Tae ^a   Choi, June Seek ^a  

^a Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; FEAR; GENICULATE NUCLEUS; MALE; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; STATE DEPENDENT LEARNING; SYNAPTIC POTENTIAL;

AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; CONDITIONING, CLASSICAL; ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; ELECTROSHOCK; EVOKED POTENTIALS; FEAR; FREEZING REACTION, CATALEPTIC; GENICULATE BODIES; MALE; MEMORY; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSES;

EID: 68549136949     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5928-08.2009     Document Type: Article

References (23)

1. Blair HT, Schafe GE, Bauer EP, Rodrigues SM, LeDoux JE (2001) Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. Learn Mem 8:229-242.
2. Blanchard DC, Blanchard RJ (1972) Innate and conditioned reactions to threat in rats with amygdaloid lesions. J Comp Physiol Psychol 81:281-290.
3. Cahill L, Weinberger NM, Roozendaal B, McGaugh JL (1999) Is the amygdala a locus of "conditioned fear"? Some questions and caveats. Neuron 23:227-228.
4. Campolattaro MM, Halverson HE, Freeman JH (2007) Medial auditory thalamic stimulation as a conditioned stimulus for eyeblink conditioning in rats. Learn Mem 14:152-159.
5. Cruikshank SJ, Edeline JM, Weinberger NM (1992) Stimulation at a site of auditory-somatosensory convergence in the medial geniculate nucleus is an effective unconditioned stimulus for fear conditioning. Behav Neurosci 106:471-483.
6. Davis M (1992) The role of the amygdala in fear and anxiety. Annu Rev Neurosci 15:353-375.
7. Edeline JM, Weinberger NM (1992) Associative retuning in the thalamic source of input to the amygdala and auditory cortex: receptive field plasticity in the medial division of the medial geniculate body. Behav Neurosci 106:81-105.
8. Fanselow MS, LeDoux JE (1999) Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala. Neuron 23:229-232.
9. Goosens KA, Hobin JA, Maren S (2003) Auditory-evoked spike firing in the lateral amygdala and Pavlovian fear conditioning: mnemonic code or fear bias? Neuron 40:1013-1022.
10. Hebb DO (1949) The organization of behavior. New York: Wiley.
11. Koo JW, Han JS, Kim JJ (2004) Selective neurotoxic lesions of basolateral and central nuclei of the amygdala produce differential effects on fear conditioning. J Neurosci 24:7654-7662.
12. LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155-184.
13. Maren S (1999) Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. Trends Neurosci 22:561-567.
14. Martin SJ, Grimwood PD, Morris RG (2000) Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 23:649-711.
15. McKernan MG, Shinnick-Gallagher P (1997) Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature 390:607-611.
16. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. San Diego: Academic.
17. Quirk GJ, Repa C, LeDoux JE (1995) Fear conditioning enhances shortlatency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat. Neuron 15:1029-1039.
18. Rogan MT, Stäubli UV, LeDoux JE (1997) Fear conditioning induces associative long-term potentiation in the amygdala. Nature 390:604-607.
19. Romanski LM, LeDoux JE (1993) Organization of rodent auditory cortex: anterograde transport of PHA-L from MGv to temporal neocortex. Cereb Cortex 3:499-514.
20. Romanski LM, Clugnet MC, Bordi F, LeDoux JE (1993) Somatosensory and auditory convergence in the lateral nucleus of the amygdala. Behav Neurosci 107:444-450.
21. Samson RD, Paré D (2005) Activity-dependent synaptic plasticity in the central nucleus of the amygdala. J Neurosci 25:1847-1855.
22. Schafe GE, Doyère V, LeDoux JE (2005) Tracking the fear engram: the lateral amygdala is an essential locus of fear memory storage. J Neurosci 25:10010-10014.
23. Steinmetz JE, Rosen DJ, Chapman PF, Lavond DG, Thompson RF (1986) Classical conditioning of the rabbit eyelid response with a mossy-fiber stimulation CS. I. Pontine nuclei and middle cerebellar peduncle stimulation. Behav Neurosci 100:878-887.