Involved intrinsic apoptotic pathway of testicular tissues in varicocele-induced rats

World Journal of Urology

Volumn 27, Issue 4, 2009, Pages 527-532

  Lee, Jane Dar ^a,d   Lee, Tsung Han ^b   Cheng, Wen Hsuan ^a   Jeng, Shaw Yeu ^c,d  

^a TAICHUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c Yuanshan Veterans Hospital   (Taiwan)

^d CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Intrinsic apoptotic pathway; Rat; Testis; Varicocele induced

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; PROTEIN BCL 2;

ANIMAL; APOPTOSIS; ARTICLE; DISEASE MODEL; LIGATION; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TESTIS; VARICOCELE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; DISEASE MODELS, ANIMAL; LIGATION; MALE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TESTIS; VARICOCELE;

EID: 68549128960     PISSN: 07244983     EISSN: 14338726     Source Type: Journal    
DOI: 10.1007/s00345-008-0367-8     Document Type: Article

References (26)

1. Naughton CK, Nangia AK, Agarwal A (2001) Varicocele and male infPrtility: Part II: pathophysiology of varicoceles in male infertility. Hum Reprod Update 7:473-481. doi: 10.1093/humupd/7.5.473
2. Redmon JB, Carey P, Pryor JL (2002) Varicocele - the most common cause of male factor infertility? Hum Reprod Update 8:53-58. doi: 10.1093/ humupd/8.1.53
3. Kilinç F, Kayaselcuk F, Aygun C et al (2004) Experimental varicocele induces hypoxia inducible factor-1alpha, vascular endothelial growth factor expression and angiogenesis in the rat testis. J Urol 172:1188-1191. doi: 10.1097/01.ju.0000135455.97627.15
4. Lee JD, Jeng SY, Lee TH (2006) Increased expression of hypoxia-inducible factor-1alpha in the internal spermatic vein of patients with varicocele. J Urol 175:1045-1048. doi: 10.1016/S0022-5347(05)00417-9
5. Barqawi A, Caruso A, Meacham RB (2004) Experimental varicocele induces testicular germ cell apoptosis in the rat. J Urol 171:501-503. doi: 10.1097/01.ju.0000088775.69010.61
6. Said TM, Paasch U, Glander HJ et al (2004) Role of caspases in male infertility. Hum Reprod Update 10:39-51. doi: 10.1093/humupd/dmh003
7. Arnoult D, Parone P, Martinou JC et al (2002) Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol 159:923-929. doi: 10.1083/jcb.200207071
8. Chipuk JE, Green DR (2005) Do inducers of apoptosis trigger caspase-independent cell death? Nat Rev Mol Cell Biol 6:268-275. doi: 10.1038/nrm1573
9. Lysiak JJ, Turner SD, Turner TT (2000) Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis. Biol Reprod 63:1465-1472. doi: 10.1095/biolreprod63.5.1465
10. Saypol DC, Howards SS, Turner TT et al (1981) Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs. J Clin Invest 68:39-45. doi: 10.1172/JCI110252
11. Turner TT (2001) The study of varicocele through the use of animal models. Hum Reprod Update 7:78-84. doi: 10.1093/humupd/7.1.78
12. Hsu HS, Wei YH, Li AF et al (1995) Defective mitochondrial oxidative phosphorylation in varicocele-bearing testicles. Urology 46:545-549. doi: 10.1016/S0090-4295(99)80270-2
13. Chakraborty J, Hikim AP, Jhunjhinwala JS (1985) Stagnation of blood in the microcirculatory vessels in the testes of men with varicocele. J Androl 6:117-126
14. Gat Y, Zukerman Z, Chakraborty J et al (2005) Varicocele, hypoxia and male infertility: Fluid Mechanics analysis of the impaired testicular venous drainage system. Hum Reprod 20:2614-2619. doi: 10.1093/humrep/ dei089
15. Ku JH, Shim HB, Kim SW et al (2005) The role of apoptosis in the pathogenesis of varicocele. BJU Int 96:1092-1096. doi: 10.1111/ j.1464-410X.2005.05807.x
16. Marmar JL (2001) Varicocele and male infertility: Part II. The pathophysiology of varicoceles in the light of current molecular and genetic information. Hum Reprod Update 7:461-472. doi: 10.1093/humupd/ 7.5.461
17. Kim JM, Ghosh SR, Weil AC et al (2001) Caspase-3 and caspase-activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone. Endocrinology 142:3809-3816. doi: 10.1210/en.142.9.3809
18. Hikim AP, Lue Y, Yamamoto CM et al (2003) Key apoptotic pathways for heat-induced programmed germ cell death in the testis. Endocrinology 144:3167-3175. doi: 10.1210/en.2003-0175
19. Nair R, Shaha C (2003) Diethylstilbestrol induces rat spermatogenic cell apoptosis in vivo through increased expression of spermatogenic cell Fas/ FasL system. J Biol Chem 278:6470-6481. doi: 10.1074/jbc.M209319200
20. Benoff SH, Millan C, Hurley IR et al (2004) Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele. Hum Reprod 19:616-627. doi: 10.1093/humrep/deh139
21. Benoff S, Gilbert BR (2001) Varicocele and male infertility: Part I. Preface. Hum Reprod Update 7:47-54. doi: 10.1093/humupd/7.1.47
22. Benoff S, Hurley IR, Barcia M et al (1997) A potential role for cadmium in the etiology of varicocele-associated infertility. Fertil Steril 67:336-347. doi: 10.1016/S0015-0282(97)81921-8
23. Celik-Ozenci C, Sahin Z, Ustunel I et al (2006) The Fas system may have a role in male reproduction. Fertil Steril 85:1168-1178. doi: 10.1016/ j.fertnstert.2005.08.058
24. Fujisawa M, Ishikawa T (2003) Soluble forms of Fas and Fas ligand concentrations in the seminal plasma of infertile men with varicocele. J Urol 170:2363-2365. doi: 10.1097/01.ju.0000095326.78152.a2
25. Tanaka H, Fujisawa M, Okada H et al (2002) Apoptosis-related proteins in the testes of infertile men with varicocele. BJU Int 89:905-909. doi: 10.1046/j.1464-410X.2002.02746.x
26. Fujisawa M, Hiramine C, Tanaka H et al (1999) Decrease in apoptosis of germ cells in the testes of infertile men with varicocele. World J Urol 17:296-300. doi: 10.1007/s003450050149