A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs: From concept to clinical trial

Biomaterials

Volumn 30, Issue 29, 2009, Pages 5260-5269

  Asnaghi, M Adelaide ^a   Jungebluth, Philipp ^b   Raimondi, Manuela T ^a,c   Dickinson, Sally C ^d   Rees, Louisa E N ^d   Go, Tetsuhiko ^b   Cogan, Tristan A ^d   Dodson, Amanda ^d   Parnigotto, Pier Paolo ^e   Hollander, Anthony P ^d   Birchall, Martin A ^f   Conconi, Maria Teresa ^e   Macchiarini, Paolo ^b   Mantero, Sara ^a  

^a POLITECNICO DI MILANO   (Italy)

^b UNIVERSITY OF BARCELONA   (Spain)

^c IRCCS ISTITUTO ORTOPEDICO GALEAZZI   (Italy)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY OF PADOVA   (Italy)

^f UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Airway transplantation; Bioreactor; Co culture; Oxygenation; Stem cells; Tissue engineering

Indexed keywords

AIRWAY TRANSPLANTATION; ANALYTICAL MODEL; ANGIOGENESIS; BIOLOGICAL PROPERTIES; CELL TYPES; CHONDROCYTES; CLINICAL TRIAL; CO-CULTURE; CRITICAL DESIGN; CULTURE MEDIA; DECELLULARIZED; EPITHELIAL CELLS; HUMAN MATRIX; MASS TRANSPORT; MATRIX; MESENCHYMAL STEM CELL; OPERATING CONDITION; ORGAN REPLACEMENT; REPOPULATION; SOCIAL PROBLEMS; STEM CELL; STEM CELLS; TRACHEAL TRANSPLANTATION;

BIOCONVERSION; BIOMECHANICS; BIOREACTORS; BODY FLUIDS; CELL MEMBRANES; FLUID DYNAMICS; INDUSTRIAL CHEMICALS; OXYGEN; OXYGENATION; OXYGENATORS; ROTATION; THREE DIMENSIONAL; TISSUE ENGINEERING;

CELL CULTURE;

ALLOTRANSPLANTATION; ARTICLE; BIOREACTOR DESIGN; CELL GROWTH; CELL ISOLATION; CELL MATURATION; CELL TRANSPORT; CELL TYPE; CLINICAL EFFECTIVENESS; COCULTURE; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDRODYNAMICS; IMPLANT; MATHEMATICAL MODEL; MESENCHYMAL STEM CELL; OXYGENATION; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; STEM CELL EXPANSION; TISSUE ENGINEERING;

BIOARTIFICIAL ORGANS; BIOREACTORS; EPITHELIAL CELLS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; ORGAN CULTURE TECHNIQUES; ROTATION; TISSUE ENGINEERING; TRACHEA; TREATMENT OUTCOME;

EID: 68549128478     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.07.018     Document Type: Article

References (42)

1. Atala A., Bauer S.B., Soker S., Yoo J.J., and Retik A.B. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet 367 (2006) 1241-1246
2. Macchiarini P., Jungebluth P., Go T., Asnaghi M.A., Rees L.E., Cogan T.A., et al. Clinical transplantation of a tissue-engineered airway. Lancet 372 (2008) 2023-2030
3. Martin I., Wendt D., and Heberer M. The role of bioreactors in tissue engineering. Trends Biotechnol 22 (2004) 80-86
4. Wendt D., Riboldi S.A., Cioffi M., and Martin I. Bioreactors in tissue engineering: scientific challenges and clinical perspectives. Adv Biochem Eng Biotechnol 112 (2009) 1-27
5. Grillo H.C. Tracheal replacement: a critical review. Ann Thorac Surg 73 (2002) 1995-2004
6. Macchiarini P. Trachea-guided generation: deja vu all over again?. J Thorac Cardiovasc Surg 128 (2004) 14-16
7. Macchiarini P. Tracheal transplantation: beyond the replacement of a simple conduit. Eur J Cardiothorac Surg 14 (1998) 621-623
8. Walles T. Bioartificial tracheal grafts: can tissue engineering keep its promise?. Expert Rev Med Devices 1 (2004) 241-250
9. Osada H., Takeuchi S., Kojima K., and Yamate N. The first step of experimental study on hybrid trachea: use of cultured fibroblasts with artificial matrix. J Cardiovasc Surg (Torino) 35 (1994) 165-168
10. Macchiarini P., Walles T., Biancosino C., and Mertsching H. First human transplantation of a bioengineered airway tissue. J Thorac Cardiovasc Surg 128 (2004) 638-641
11. Kim J., Suh S.W., Shin J.Y., Kim J.H., Choi Y.S., and Kim H. Replacement of a tracheal defect with a tissue-engineered prosthesis: early results from animal experiments. J Thorac Cardiovasc Surg 128 (2004) 124-129
12. Kojima K., and Vacanti C.A. Generation of a tissue-engineered tracheal equivalent. Biotechnol Appl Biochem 39 (2004) 257-262
13. Walles T., Giere B., Hofmann M., Schanz J., Hofmann F., Mertsching H., et al. Experimental generation of a tissue-engineered functional and vascularized trachea. J Thorac Cardiovasc Surg 128 (2004) 900-906
14. Wu W., Cheng X., Zhao Y., Chen F., Feng X., and Mao T. Tissue engineering of trachea-like cartilage grafts by using chondrocyte macroaggregate: experimental study in rabbits. Artif Organs 31 (2007) 826-834
15. Palsson B.O., and Bhatia S.N. Scaling up for ex vivo cultivation. Tissue engineering (2004), Pearson-Prentice Hall, Upper Saddle River, NJ p. 223-43
16. Kondo M., Tamaoki J., Sakai A., Kameyama S., Kanoh S., and Konno K. Increased oxidative metabolism in cow tracheal epithelial cells cultured at air-liquid interface. Am J Respir Cell Mol Biol 16 1 (1997) 62-68
17. Godara P., McFArland C.D., and Nordon R.E. Design of bioreactors for mesenchymal stem cell tissue engineering. J Chem Technol Biotechnol 83 (2008) 408-420
18. Galbusera F., Cioffi M., Raimondi M.T., and Pietrabissa R. Computational modeling of combined cell population dynamics and oxygen transport in engineered tissue subject to interstitial perfusion. Comput Methods Biomech Biomed Engin 10 4 (2007) 279-287
19. Kafienah W., Mistry S., Williams C., and Hollander A.P. Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow. Stem Cells 24 (2006) 1113-1120
20. Kafienah W., Mistry S., Dickinson S.C., Sims T.J., Learmonth I., and Hollander A.P. Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients. Arthritis Rheum 56 (2007) 177-187
21. Dickinson S.C., Sims T.J., Pittarello L., Soranzo C., Pavesio A., and Hollander A.P. Quantitative outcome measures of cartilage repair in patients treated by tissue engineering. Tissue Eng 11 (2005) 277-287
22. Rees L.E., Gunasekaran S., Sipaul F., Birchall M.A., and Bailey M. The isolation and characterisation of primary human laryngeal epithelial cells. Mol Immunol 43 (2006) 725-730
23. Conconi M.T., De Coppi P., Di Liddo R., Vigolo S., Zanon G.F., Parnigotto P.P., et al. Tracheal matrices, obtained by a detergent-enzymatic method, support in vitro the adhesion of chondrocytes and tracheal epithelial cells. Transpl Int 18 (2005) 727-734
24. Jungebluth P, Go T, Asnaghi MA, Bellini S, Martorell J, Calore C, et al. Structural and morphological evaluation of a new detergent-enzymatic tissue engineered tracheal tubular matrix. J Thorac Cardiovasc Surg, in press.
25. Rees L.E., Pazmany L., Gutowska-Owsiak D., Inman C.F., Phillips A., Stokes C.R., et al. The mucosal immune response to laryngopharyngeal reflux. Am J Respir Crit Care Med 177 11 (2008) 1187-1193
26. Barker E., Haverson K., Stokes C.R., Birchall M., and Bailey M. The larynx as an immunological organ: immunological architecture in the pig as a large animal model. Clin Exp Immunol 143 (2006) 6-14
27. Priya S.G., Jungvid H., and Kumar A. Skin tissue engineering for tissue repair and regeneration. Tissue Eng Part B Rev 14 (2008) 105-118
28. Lichtenberg A., Tudorache I., Cebotari S., Ringes-Lichtenberg S., Sturz G., Hoeffler K., et al. In vitro re-endothelialization of detergent decellularized heart valves under simulated physiological dynamic conditions. Biomaterials 27 (2006) 4221-4229
29. Radisic M., Marsano A., Maidhof R., Wang Y., and Vunjak-Novakovic G. Cardiac tissue engineering using perfusion bioreactor systems. Nat Protoc 3 (2008) 719-738
30. Arrigoni C., Chitto A., Mantero S., and Remuzzi A. Rotating versus perfusion bioreactor for the culture of engineered vascular constructs based on hyaluronic acid. Biotechnol Bioeng 100 (2008) 988-997
31. Kim B.S., Nikolovski J., Bonadio J., and Mooney D.J. Cyclic mechanical strain regulates the development of engineered smooth muscle tissue. Nat Biotechnol 17 (1999) 979-983
32. Huang C.Y., Hagar K.L., Frost L.E., Sun Y., and Cheung H.S. Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells 22 (2004) 313-323
33. Mantero S., Sadr N., Riboldi S.A., Lorenzoni S., and Montevecchi F.M. A new electro-mechanical bioreactor for soft tissue engineering. JABB 5 (2007) 107-116
34. Flanagan T.C., Cornelissen C., Koch S., Tschoeke B., Sachweh J.S., Schmitz-Rode T., et al. The in vitro development of autologous fibrin-based tissue-engineered heart valves through optimised dynamic conditioning. Biomaterials 28 (2007) 3388-3397
35. Ritchie A.C., Wijaya S., Ong W.F., Zhong S.P., and Chian K.S. Dependence of alignment direction on magnitude of strain in esophageal smooth muscle cells. Biotechnol Bioeng 102 (2009) 1703-1711
36. Janssen F.W., Oostra J., Oorschot A., and van Blitterswijk C.A. A perfusion bioreactor system capable of producing clinically relevant volumes of tissue-engineered bone: in vivo bone formation showing proof of concept. Biomaterials 27 (2006) 315-323
37. Radisic M., Deen W., Langer R., and Vunjak-Novakovic G. Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers. Am J Physiol Heart Circ Physiol 288 (2005) H1278-H1289
38. Botchwey E.A., Dupree M.A., Pollack S.R., Levine E.M., and Laurencin C.T. Tissue engineered bone: measurement of nutrient transport in three-dimensional matrices. J Biomed Mater Res A 67 (2003) 357-367
39. Zhao F., Pathi P., Grayson W., Xing Q., Locke B.R., and Ma T. Effects of oxygen transport on 3-D human mesenchymal stem cell metabolic activity in perfusion and static cultures: experiments and mathematical model. Biotechnol Prog 21 (2005) 1269-1280
40. Williams K.A., Saini S., and Wick T.M. Computational fluid dynamics modeling of steady-state momentum and mass transport in a bioreactor for cartilage tissue engineering. Biotechnol Prog 18 (2002) 951-963
41. Sengers B.G., van Donkelaar C.C., Oomens C.W., and Baaijens F.P. Computational study of culture conditions and nutrient supply in cartilage tissue engineering. Biotechnol Prog 21 (2005) 1252-1261
42. Zhou S., Cui Z., and Urban J.P. Nutrient gradients in engineered cartilage: metabolic kinetics measurement and mass transfer modeling. Biotechnol Bioeng 101 2 (2008) 408-421