The transcription factor ITF-2A induces cell cycle arrest via p21Cip1

Biochemical and Biophysical Research Communications

Volumn 387, Issue 4, 2009, Pages 736-740

  Herbst, Andreas ^a   Helferich, Simone ^a   Behrens, Andrea ^a   Göke, Burkhard ^a   Kolligs, Frank T ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cip1; Colorectal cancer; ITF2; Transcription

Indexed keywords

BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ITF 2A; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CHROMOSOME 17P; CHROMOSOME 18Q; CHROMOSOME 5Q; CHROMOSOME 8P; COLORECTAL TUMOR; CONTROLLED STUDY; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; ITF2 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMOSOMES, HUMAN, PAIR 18; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; LOSS OF HETEROZYGOSITY; PROTEIN ISOFORMS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 68549125037     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.07.102     Document Type: Article

References (14)

1. Vogelstein B., Fearon E.R., Kern S.E., Hamilton S.R., Preisinger A.C., Nakamura Y., and White R. Allelotype of colorectal carcinomas. Science 244 (1989) 207-211
2. A. Herbst, G.T. Bommer, L. Kriegl, A. Jung, A. Behrens, E. Csanadi, M. Gerhard, C. Bolz, R. Riesenberg, W. Zimmermann, W. Dietmaier, I. Wolf, T. Brabletz, B. Goke, F.T. Kolligs, ITF-2 is disrupted via allelic loss of chromosome 18q21 and ITF-2B expression is lost at the adenoma-carcinoma transition, Gastroenterology, 2009.
3. Massari M.E., and Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20 (2000) 429-440
4. Herbst A., and Kolligs F.T. A conserved domain in the transcription factor ITF-2B attenuates its activity. Biochem. Biophys. Res. Commun. 370 (2008) 327-331
5. Atchley W.R., and Fitch W.M. A natural classification of the basic helix-loop-helix class of transcription factors. Proc. Natl. Acad. Sci. USA 94 (1997) 5172-5176
6. Ruzinova M.B., and Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell Biol. 13 (2003) 410-418
7. Flora A., Garcia J.J., Thaller C., and Zoghbi H.Y. The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors. Proc. Natl. Acad. Sci. USA 104 (2007) 15382-15387
8. Lassar A.B., Davis R.L., Wright W.E., Kadesch T., Murre C., Voronova A., Baltimore D., and Weintraub H. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell 66 (1991) 305-315
9. Murre C. Helix-loop-helix proteins and lymphocyte development. Nat. Immunol. 6 (2005) 1079-1086
10. Skerjanc I.S., Truong J., Filion P., and McBurney M.W. A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity. J. Biol. Chem. 271 (1996) 3555-3561
11. Muir T., Sadler-Riggleman I., Stevens J.D., and Skinner M.K. Role of the basic helix-loop-helix protein ITF2 in the hormonal regulation of Sertoli cell differentiation. Mol. Reprod. Dev. 73 (2006) 491-500
12. Parrinello S., Lin C.Q., Murata K., Itahana Y., Singh J., Krtolica A., Campisi J., and Desprez P.Y. Id-1, ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis. J. Biol. Chem. 276 (2001) 39213-39219
13. Kolligs F.T., Nieman M.T., Winer I., Hu G., Van Mater D., Feng Y., Smith I.M., Wu R., Zhai Y., Cho K.R., and Fearon E.R. ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. Cancer Cell 1 (2002) 145-155
14. Bornkamm G.W., Berens C., Kuklik-Roos C., Bechet J.M., Laux G., Bachl J., Korndoerfer M., Schlee M., Holzel M., Malamoussi A., Chapman R.D., Nimmerjahn F., Mautner J., Hillen W., Bujard H., and Feuillard J. Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res. 33 (2005) e137