메뉴 건너뛰기




Volumn 58, Issue 10, 2009, Pages 1647-1655

Recombinant bacillus Calmette-Guérin (BCG) expressing interferon-alpha 2B enhances human mononuclear cell cytotoxicity against bladder cancer cell lines in vitro

Author keywords

BCG; Bladder cancer; Cytotoxicity; IFN

Indexed keywords

ALPHA2B INTERFERON; ANTINEOPLASTIC AGENT; BCG VACCINE; IMMUNOLOGICAL ADJUVANT; RECOMBINANT PROTEIN;

EID: 68549123471     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-009-0673-z     Document Type: Article
Times cited : (40)

References (49)
  • 2
    • 0029283820 scopus 로고
    • Bacillus Calmette-Guérin immunotherapy for superficial bladder cancer. New prospects for an old warhorse
    • O'Donnell MA, DeWolf DC (1995) Bacillus Calmette-Guérin immunotherapy for superficial bladder cancer. New prospects for an old warhorse. Surg Oncol Clin N Am 4:189-202
    • (1995) Surg Oncol Clin N Am , vol.4 , pp. 189-202
    • O'Donnell, M.A.1    DeWolf, D.C.2
  • 3
    • 0033562695 scopus 로고    scopus 로고
    • BCG immunotherapy of bladder cancer: 20 years on
    • DOI 10.1016/S0140-6736(98)07422-4
    • Alexandroff AB, Jackson AM, O'Donnell MA, James K (1999) BCG immunotherapy of bladder cancer: 20 years on. Lancet 353:1689-1694 (Pubitemid 29224536)
    • (1999) Lancet , vol.353 , Issue.9165 , pp. 1689-1694
    • Alexandroff, A.B.1    Jackson, A.M.2    O'Donnell, M.A.3    James, K.4
  • 4
    • 0025351905 scopus 로고
    • Effects of local bacillus Calmette-Guerin therapy in patients with bladder carcinoma on immunocompetent cells of the bladder wall
    • Bohle A, Gerdes J, Ulmer AJ, Hofstetter AG, Flad HD (1990) Effects of local bacillus Calmette-Guérin therapy in patients with bladder carcinoma on immunocompetent cells of the bladder wall. J Urol 144:53-58 (Pubitemid 20221267)
    • (1990) Journal of Urology , vol.144 , Issue.1 , pp. 53-58
    • Bohle, A.1    Gerdes, J.2    Ulmer, A.J.3    Hofstetter, A.G.4    Flad, H.-D.5
  • 5
    • 0026717957 scopus 로고
    • Intravesical Evans strain BCG therapy: Quantitative immunohistochemical analysis of the immune response within the bladder wall
    • Prescott S, James K, Hargreave TB, Chisholm GD, Smyth JF (1992) Intravesical Evans strain BCG therapy: quantitative immunohistochemical analysis of the immune response within the bladder wall. J Urol 147:1636-1642
    • (1992) J Urol , vol.147 , pp. 1636-1642
    • Prescott, S.1    James, K.2    Hargreave, T.B.3    Chisholm, G.D.4    Smyth, J.F.5
  • 6
    • 0024441451 scopus 로고
    • Analysis of mucosal bladder leucocyte subpopulations in patients treated with intravesical bacillus calmette-guerin
    • Peuchmaur M, Benoit G, Vieillefond A, Chevalier A, Lemaigre G, Martin ED, Jardin A (1989) Analysis of mucosal bladder leucocyte subpopulations in patients treated with intravesical bacillus Calmette-Guérin. Urol Res 17:299-303 (Pubitemid 19228627)
    • (1989) Urological Research , vol.17 , Issue.5 , pp. 299-303
    • Peuchmaur, M.1    Benoit, G.2    Vieillefond, A.3    Chevalier, A.4    Lemaigre, G.5    Martin, E.D.6    Jardin, A.7
  • 10
    • 0025291839 scopus 로고
    • Elevations of cytokines interleukin-1, interleukin-2 and tumor necrosis factor in the urine of patients after intravesical bacillus Calmette-Guerin immunotherapy
    • Bohle A, Nowc C, Ulmer AJ, Musehold J, Gerdes J, Hofstetter AG, Flad HD (1990) Elevations of cytokines interleukin-1, interleukin- 2 and tumor necrosis factor in the urine of patients after intravesical bacillus Calmette- Guérin immunotherapy. J Urol 144:59-64 (Pubitemid 20221268)
    • (1990) Journal of Urology , vol.144 , Issue.1 , pp. 59-64
    • Bohle, A.1    Nowc, C..2    Ulmer, A.J.3    Musehold, J.4    Gerdes, J.5    Hofstetter, A.G.6    Flad, H.-D.7
  • 11
    • 0030051368 scopus 로고    scopus 로고
    • Urinary cytokines during intravesical bacillus Calmette-Guerin therapy for superficial bladder cancer: Processing, stability and prognostic value
    • DOI 10.1016/S0022-5347(01)66424-3
    • de Reijke TM, de Boer EC, Kurth KH, Schamhart DH (1996) Urinary cytokines during intravesical bacillus Calmette-Guérin therapy for superficial bladder cancer: processing, stability and prognostic value. J Urol 155:477-482 (Pubitemid 26023528)
    • (1996) Journal of Urology , vol.155 , Issue.2 , pp. 477-482
    • De Reijke, T.M.1    De Boer, E.C.2    Kurth, K.H.3    Schamhart, D.H.J.4
  • 12
    • 0033757837 scopus 로고    scopus 로고
    • Urinary interleukin-8 and 18 predict the response of superficial bladder cancer to intravesical therapy with bacillus Calmette-Guérin
    • Thalmann GN, Sermier A, Rentsch C, Mohrle K, Cecchini MG, Studer UE (2000) Urinary interleukin-8 and 18 predict the response of superficial bladder cancer to intravesical therapy with bacillus Calmette-Guérin. J Urol 164:2129-2133
    • (2000) J Urol , vol.164 , pp. 2129-2133
    • Thalmann, G.N.1    Sermier, A.2    Rentsch, C.3    Mohrle, K.4    Cecchini, M.G.5    Studer, U.E.6
  • 13
    • 0032145962 scopus 로고    scopus 로고
    • Intravesical bacille Calmette-Guerin induces the antiangiogenic chemokine interferon-inducible protein 10
    • Poppas DP, Pavlovich CP, Folkman J, Voest EE, Chen X, Luster AD, O'Donnell MA (1998) Intravesical bacille Calmette-Guerin induces the antiangiogenic chemokine interferon-inducible protein 10. Urology 52:268-275
    • (1998) Urology , vol.52 , pp. 268-275
    • Poppas, D.P.1    Pavlovich, C.P.2    Folkman, J.3    Voest, E.E.4    Chen, X.5    Luster, A.D.6    O'Donnell, M.A.7
  • 14
    • 0037318434 scopus 로고    scopus 로고
    • Interleukin 10 induced augmentation of delayed-type hypersensitivity (DTH) enhances Mycobacterium bovis bacillus Calmette-Guérin (BCG) mediated antitumour activity
    • DOI 10.1046/j.1365-2249.2003.02071.x
    • Nadler R, Luo Y, Zhao W, Ritchey JK, Austin JC, Cohen MB, O'Donnell MA, Ratliff TL (2003) Interleukin 10 induced augmentation of delayed-type hypersensitivity (DTH) enhances Mycobacterium bovis bacillus Calmette-Guérin (BCG) mediated antitumour activity. Clin Exp Immunol 131:206-216 (Pubitemid 36205130)
    • (2003) Clinical and Experimental Immunology , vol.131 , Issue.2 , pp. 206-216
    • Nadler, R.1    Luo, Y.2    Zhao, W.3    Ritchey, J.K.4    Austin, J.C.5    Cohen, M.B.6    O'Donnell, M.A.7    Ratliff, T.L.8
  • 15
    • 33846189767 scopus 로고    scopus 로고
    • Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces human CC- and CXC-chemokines in vitro and in vivo
    • DOI 10.1111/j.1365-2249.2006.03288.x
    • Luo Y, Chen X, O'Donnell MA (2007) Mycobacterium bovis bacillus Calmette-Guerin (BCG) induces human CC- and CXC-chemokines in vitro and in vivo. Clin Exp Immunol 147:370-378 (Pubitemid 46096016)
    • (2007) Clinical and Experimental Immunology , vol.147 , Issue.2 , pp. 370-378
    • Luo, Y.1    Chen, X.2    O'Donnell, M.A.3
  • 16
    • 0027742001 scopus 로고
    • Dissecting the immunobiological effects of bacillus Calmette-Guerin (BCG) in vitro: Evidence of a distinct BCG-activated killer (BAK) cell phenomenon
    • Böhle A, Thanhäuser A, Ulmer AJ, Ernst M, Flad HD, Jocham D (1993) Dissecting the immunobiological effects of bacillus Calmette- Guérin (BCG) in vitro: evidence of a distinct BCG-activated killer (BAK) cell phenomenon. J Urol 150:1932-1937 (Pubitemid 24350840)
    • (1993) Journal of Urology , vol.150 , Issue.6 , pp. 1932-1937
    • Bohle, A.1    Thanhauser, A.2    Ulmer, A.J.3    Ernst, M.4    Flad, H.-D.5    Jocham, D.6
  • 18
    • 0027154285 scopus 로고
    • Induction of bacillus-Calmette-Guerin-activated killer cells from human peripheral blood mononuclear cells against human bladder carcinoma cell lines in vitro
    • Thanhäuser A, Böhle A, Flad HD, Ernst M, Mattern T, Ulmer AJ (1993) Induction of bacillus-Calmette-Guérin-activated killer cells from human peripheral blood mononuclear cells against human bladder carcinoma cell lines in vitro. Cancer Immunol Immunother 37:105-111 (Pubitemid 23175045)
    • (1993) Cancer Immunology Immunotherapy , vol.37 , Issue.2 , pp. 105-111
    • Thanhauser, A.1    Bohle, A.2    Flad, H.-D.3    Ernst, M.4    Mattern, T.5    Ulmer, A.J.6
  • 21
    • 0027177646 scopus 로고
    • Phenotypic and cell cycle analysis of human peripheral blood mononuclear cells activated with interleukin-2 and/or OKT3
    • Platts KE, Lawry J, Hancock BW, Rees RC (1993) Phenotypic and cell cycle analysis of human peripheral blood mononuclear cells activated with interleukin-2 and/or OKT3. Exp Cell Res 208:154- 160
    • (1993) Exp Cell Res , vol.208 , pp. 154-160
    • Platts, K.E.1    Lawry, J.2    Hancock, B.W.3    Rees, R.C.4
  • 22
    • 0031746868 scopus 로고    scopus 로고
    • Immune response following intravesical bacillus Calmette-Guerin instillations in superficial madder cancer: A review
    • DOI 10.1007/s002400050039
    • Patard JJ, Saint F, Velotti F, Abbou CC, Chopin DK (1998) Immune response following intravesical bacillus Calmette-Guerin instillations in superficial bladder cancer: a review. Urol Res 26:155-159 (Pubitemid 28305378)
    • (1998) Urological Research , vol.26 , Issue.3 , pp. 155-159
    • Patard, J.J.1    Saint, F.2    Velotti, F.3    Abbou, C.C.4    Chopin, D.K.5
  • 23
    • 0026725003 scopus 로고
    • Long-term results of intravesical therapy for superficial bladder cancer
    • Lamm DL (1992) Long-term results of intravesical therapy for superficial bladder cancer. Urol Clin North Am 19:573-580
    • (1992) Urol Clin North Am , vol.19 , pp. 573-580
    • Lamm, D.L.1
  • 24
    • 0025888356 scopus 로고
    • Long-term complete remission in bladder carcinoma in situ with intravesical tice bacillus Calmette-Guérin
    • Dejager R, Guinan P, Lamm D (1991) Long-term complete remission in bladder carcinoma in situ with intravesical tice bacillus Calmette- Guérin. Urology 38:507-513
    • (1991) Urology , vol.38 , pp. 507-513
    • Dejager, R.1    Guinan, P.2    Lamm, D.3
  • 26
    • 0028811241 scopus 로고
    • BCG vs. BCG plus recombinant alpha-interferon 2b in superficial tumors of the bladder
    • Bercovich E, Deriu M, Manferrari F, Irianni G (1995) BCG vs. BCG plus recombinant alpha-interferon 2b in superficial tumors of the bladder. Arch Ital Urol Androl 67:257-260
    • (1995) Arch Ital Urol Androl , vol.67 , pp. 257-260
    • Bercovich, E.1    Deriu, M.2    Manferrari, F.3    Irianni, G.4
  • 28
    • 0033557730 scopus 로고    scopus 로고
    • IFN-α 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guerin immunotherapy
    • Luo Y, Chen X, Downs TM, DeWolf WC, O'Donnell MA (1999) IFN-α 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guérin immunotherapy. J Immunol 162:2399-2405 (Pubitemid 29288868)
    • (1999) Journal of Immunology , vol.162 , Issue.4 , pp. 2399-2405
    • Luo, Y.1    Chen, X.2    Downs, T.M.3    DeWolf, W.C.4    O'Donnell, M.A.5
  • 29
    • 33745513016 scopus 로고    scopus 로고
    • {star, open}
    • DOI 10.1016/j.urolonc.2005.11.026, PII S1078143905002966
    • Joudi FN, Smith BJ, O'Donnell MA, National BCG-interferon phase 2 investigator group (2006) Final results from a national multicenter phase II trial of combination bacillus Calmette-Guerin plus interferon alpha-2B for reducing recurrence of superficial bladder cancer. Urol Oncol 24:344-348 (Pubitemid 43963411)
    • (2006) Urologic Oncology: Seminars and Original Investigations , vol.24 , Issue.4 SPEC. ISS. , pp. 344-348
    • Joudi, F.N.1    Smith, B.J.2    O'Donnell, M.A.3
  • 30
    • 0037422679 scopus 로고    scopus 로고
    • Role of Th1 and Th2 cytokines in BCG-induced IFN-gamma production: Cytokine promotion and simulation of BCG effect
    • DOI 10.1016/S1043-4666(02)00490-8
    • Luo Y, Chen X, O'Donnell MA (2003) Role of Th1 and Th2 cytokines in BCG-induced IFN-gamma production: cytokine promotion and simulation of BCG effect. Cytokine 21:17-26 (Pubitemid 36369372)
    • (2003) Cytokine , vol.21 , Issue.1 , pp. 17-26
    • Luo, Y.1    Chen, X.2    O'Donnell, M.A.3
  • 31
    • 34250214973 scopus 로고    scopus 로고
    • Dose-dependent synergy of Th1-stimulating cytokines on bacille Calmette-Guérin-induced interferon-gamma production by human mononuclear cells
    • DOI 10.1111/j.1365-2249.2007.03413.x
    • Chen X, O'Donnell MA, Luo Y (2007) Dose-dependent synergy of Th1-stimulating cytokines on bacille Calmette-Guérin-induced interferon-gamma production by human mononuclear cells. Clin Exp Immunol 149:178-185 (Pubitemid 46897114)
    • (2007) Clinical and Experimental Immunology , vol.149 , Issue.1 , pp. 178-185
    • Chen, X.1    O'Donnell, M.A.2    Luo, Y.3
  • 32
    • 0345426323 scopus 로고    scopus 로고
    • Effects of bacillus Calmette-Guerin and interferon alpha-2b on cytokine production in human bladder cancer cell lines
    • DOI 10.1016/S0022-5347(01)61832-9
    • Zhang Y, Khoo HE, Esuvaranathan K (1999) Effects of bacillus Calmette-Guèrin and interferon alpha-2B on cytokine production in human bladder cancer cell lines. J Urol 161:977-983 (Pubitemid 29422419)
    • (1999) Journal of Urology , vol.161 , Issue.3 , pp. 977-983
    • Zhang, Y.E.1    Khoo, H.E.2    Esuvaranathan, K.3
  • 33
    • 0029588538 scopus 로고
    • Antiproliferative effects of bacillus Calmette-Guerin and interferon alpha 2b on human bladder cancer cells in vitro
    • DOI 10.1007/s002620050233
    • Pryor K, Stricker P, Russell P, Golovsky D, Penny R (1995) Antiproliferative effects of bacillus Calmette-Guerin and interferon alpha 2b on human bladder cancer cells in vitro. Cancer Immunol Immunother 41:309-316 (Pubitemid 26008823)
    • (1995) Cancer Immunology Immunotherapy , vol.41 , Issue.5 , pp. 309-316
    • Pryor, K.1    Stricker, P.2    Russell, P.3    Golovsky, D.4    Penny, R.5
  • 34
    • 0035119134 scopus 로고    scopus 로고
    • Recombinant bacille Calmette-Guérin (BCG) expressing human interferon-alpha 2B demonstrates enhanced immunogenicity
    • DOI 10.1046/j.1365-2249.2001.01428.x
    • Luo Y, Chen X, Han R, O'Donnell MA (2001) Recombinant bacille Calmette-Guérin (BCG) expressing human interferon-alpha 2B demonstrates enhanced immunogenicity. Clin Exp Immunol 123:264-270 (Pubitemid 32174778)
    • (2001) Clinical and Experimental Immunology , vol.123 , Issue.2 , pp. 264-270
    • Luo, Y.1    Chen, X.2    Han, R.3    O'Donnell, M.A.4
  • 35
    • 0028291925 scopus 로고
    • Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes
    • O'Donnell MA, Aldovini A, Duda RB, Yang H, Szilvasi A, Young RA, DeWolf WC (1994) Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes. Infect Immun 62:2508-2514 (Pubitemid 24157083)
    • (1994) Infection and Immunity , vol.62 , Issue.6 , pp. 2508-2514
    • O'Donnell, M.A.1    Aldovini, A.2    Duda, R.B.3    Yang, H.4    Szilvasi, A.5    Young, R.A.6    DeWolf, W.C.7
  • 36
    • 0034912476 scopus 로고    scopus 로고
    • Activation of natural killer cells by bacillus Calmette-Guérin
    • DOI 10.1159/000052497
    • Brandau S, Böhle A (2001) Activation of natural killer cells by bacillus Calmette-Guérin. Eur Urol 39:518-524 (Pubitemid 32678965)
    • (2001) European Urology , vol.39 , Issue.5 , pp. 518-524
    • Brandau, S.1    Bohle, A.2
  • 38
    • 4544226709 scopus 로고    scopus 로고
    • Mechanisms of bacillus Calmette-Guerin mediated natural killer cell activation
    • DOI 10.1097/01.ju.0000131944.52354.63
    • Suttmann H, Jacobsen M, Reiss K, Jocham D, Böhle A, Brandau S (2004) Mechanisms of bacillus Calmette-Guerin mediated natural killer cell activation. J Urol 172:1490-1495 (Pubitemid 39249755)
    • (2004) Journal of Urology , vol.172 , Issue.4 I , pp. 1490-1495
    • Suttmann, H.1    Jacobsen, M.2    Reiss, K.3    Jocham, D.4    Bohle, A.5    Brandau, S.6
  • 39
    • 34250817996 scopus 로고    scopus 로고
    • Bacillus Calmette-Guérin-pulsed dendritic cells stimulate natural killer T cells and gammadeltaT cells
    • DOI 10.1111/j.1442-2042.2006.01697.x
    • Naoe M, Ogawa Y, Takeshita K, Morita J, Iwamoto S, Miyazaki A, Yoshida H (2007) Bacillus Calmette-Guérin-pulsed dendritic cells stimulate natural killer T cells and gammadeltaT cells. Int J Urol 14:532-538 (Pubitemid 46985528)
    • (2007) International Journal of Urology , vol.14 , Issue.6 , pp. 532-538
    • Naoe, M.1    Ogawa, Y.2    Takeshita, K.3    Morita, J.4    Iwamoto, S.5    Miyazaki, A.6    Yoshida, H.7
  • 40
    • 0034954034 scopus 로고    scopus 로고
    • Interferons alpha and beta as immune regulators - A new look
    • Biron CA (2001) Interferons alpha and beta as immune regulators - a new look. Immunity 14:661-664
    • (2001) Immunity , vol.14 , pp. 661-664
    • Biron, C.A.1
  • 42
    • 0030734114 scopus 로고    scopus 로고
    • Interleukin-12 gene expression in human monocyte-derived macrophages stimulated with Mycobacterium bovis BCG: Cytokine regulation and effect of NK cells
    • Matsumoto H, Suzuki K, Tsuyuguchi K, Tanaka E, Amitani R, Maeda A, Yamamoto K, Sasada M, Kuze F (1997) Interleukin-12 gene expression in human monocyte-derived macrophages stimulated with Mycobacterium bovis BCG: cytokine regulation and effect of NK cells. Infect Immun 65:4405-4410 (Pubitemid 27463204)
    • (1997) Infection and Immunity , vol.65 , Issue.11 , pp. 4405-4410
    • Matsumoto, H.1    Suzuki, K.2    Tsuyuguchi, K.3    Tanaka, E.4    Amitani, R.5    Maeda, A.6    Yamamoto, K.7    Sasada, M.8    Kuze, F.9
  • 43
    • 2342556573 scopus 로고    scopus 로고
    • Functional characterization of human natural killer cells responding to Mycobacterium bovis bacille Calmette-Guérin
    • DOI 10.1111/j.1365-2567.2004.01858.x
    • Esin S, Batoni G, Pardini M, Favilli F, Bottai D, Maisetta G, Florio W, Vanacore R, Wigzell H, Campa M (2004) Functional characterization of human natural killer cells responding to Mycobacterium bovis bacille Calmette-Guerin. Immunology 112:143-152 (Pubitemid 38609832)
    • (2004) Immunology , vol.112 , Issue.1 , pp. 143-152
    • Esin, S.1    Batoni, G.2    Pardini, M.3    Favilli, F.4    Bottai, D.5    Maisetta, G.6    Florio, W.7    Vanacore, R.8    Wigzell, H.9    Campa, M.10
  • 44
    • 0027491655 scopus 로고
    • + T cells to enhance priming for interferon-γproduction and diminishes interleukin 4 inhibition of such priming
    • + T cells to enhance priming for interferon- γproduction and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci USA 90:10188-10192
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10188-10192
    • Seder, R.A.1    Gazzinelli, R.2    Sher, A.3    Paul, W.E.4
  • 45
    • 0024437777 scopus 로고
    • The interleukins
    • Mizel SB (1989) The interleukins. FASEB J 3:2379-2388
    • (1989) FASEB J , vol.3 , pp. 2379-2388
    • Mizel, S.B.1
  • 46
    • 0026856589 scopus 로고
    • Immunomodulatory effect of interferon-alpha 2b on natural killer cells and T lymphocytes from patients with transitional cell carcinoma of the bladder
    • Alvarez-Mon M, Moltó LM, Manzano L, Olivier C, Carballido JA (1992) Immunomodulatory effect of interferon-alpha 2b on natural killer cells and T lymphocytes from patients with transitional cell carcinoma of the bladder. Anticancer Drugs 3(Suppl 1):5-8
    • (1992) Anticancer Drugs , vol.3 , Issue.SUPPL. 1 , pp. 5-8
    • Alvarez-Mon, M.1    Moltó, L.M.2    Manzano, L.3    Olivier, C.4    Carballido, J.A.5
  • 47
    • 0027944140 scopus 로고
    • Intracavitary prophylactic treatment with interferon alpha 2b of patients with superficial bladder cancer is associated with a systemic T-cell activation
    • Moltó L, Alvarez-Mon M, Carballido J, Manzano L, Guillen C, Prieto A, Olivier C, Rodriguez-Zapata M (1994) Intracavitary prophylactic treatment with interferon alpha 2b of patients with superficial bladder cancer is associated with a systemic T-cell activation. Br J Cancer 70:1247-1251 (Pubitemid 24358971)
    • (1994) British Journal of Cancer , vol.70 , Issue.6 , pp. 1247-1251
    • Molto, L.1    Alvarez-Mon, M.2    Carballido, J.3    Manzano, L.4    Guillen, C.5    Prieto, A.6    Olivier, C.7    Rodriguez-Zapata, M.8
  • 48
    • 17644396990 scopus 로고    scopus 로고
    • Novel insights into the mechanism of action of intravesical immunomodulators
    • Mitropoulos DN (2005) Novel insights into the mechanism of action of intravesical immunomodulators. In Vivo 19:611-621
    • (2005) In Vivo , vol.19 , pp. 611-621
    • Mitropoulos, D.N.1
  • 49
    • 0032719528 scopus 로고    scopus 로고
    • Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule
    • Slaton JW, Perrotte P, Inoue K, Dinney CP, Fidler IJ (1999) Interferon- alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res 5:2726-2734 (Pubitemid 29493945)
    • (1999) Clinical Cancer Research , vol.5 , Issue.10 , pp. 2726-2734
    • Slaton, J.W.1    Perrotte, P.2    Inoue, K.3    Dinney, C.P.N.4    Fidler, I.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.