A large prospective observational study of novel cyclosporine 0.1% aqueous ophthalmic solution in the treatment of severe allergic conjunctivitis

Journal of Ocular Pharmacology and Therapeutics

Volumn 25, Issue 4, 2009, Pages 365-371

  Ebihara, Nobuyuki ^a   Ohashi, Yuichi ^b   Uchio, Eiichi ^c   Okamoto, Shigeki ^d   Kumagai, Naoki ^e   Shoji, Jun ^f   Takamura, Etsuko ^g   Nakagawa, Yayoi ^h   Nanba, Kenichi ⁱ   Fukushima, Atsuki ^j   Fujishima, Hiroshi ^k  

^a JUNTENDO UNIVERSITY   (Japan)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

^d Okamoto Eye Clinic   (Japan)

^e Kumagai Eye Clinic   (Japan)

^f NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^h Nakagawa Eye Clinic   (Japan)

ⁱ HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^j KOCHI MEDICAL SCHOOL   (Japan)

^k International University of Health and Welfare Mita Hospital   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; CYCLOSPORIN; PAPILOCK MINI; STEROID; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; ATOPIC KERATOCONJUNCTIVITIS; BACTERIAL INFECTION; CHEMOSIS; CHILD; CLINICAL TRIAL; CONJUNCTIVA; CONTROLLED STUDY; CORNEA LIMBUS; CORNEA ULCER; DRUG EFFICACY; DRUG MARKETING; DRUG SAFETY; DRUG SURVEILLANCE PROGRAM; DRUG WITHDRAWAL; EYE DISCHARGE; EYE IRRITATION; EYE PAIN; FEMALE; FOLLOW UP; HERPES SIMPLEX KERATITIS; HUMAN; HYPEREMIA; INTRAOCULAR PRESSURE; JAPAN; KERATITIS; MAJOR CLINICAL STUDY; MALE; OCULAR PRURITUS; PHOTOPHOBIA; SCHOOL CHILD; TREATMENT DURATION; VERNAL CONJUNCTIVITIS; VISUAL ACUITY;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; CHILD; CONJUNCTIVITIS, ALLERGIC; CYCLOSPORINE; FEMALE; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JAPAN; KERATOCONJUNCTIVITIS; MALE; OPHTHALMIC SOLUTIONS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 68549120872     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2008.0103     Document Type: Article

References (25)

1. Udell, I.J., Gleich, G.J., and Allansmith, M.R. Eosinophil granule major basic protein and Charcot-Leyden crystal protein in human tears. Am. J. Ophthalmol. 92:824-828, 1981. (Pubitemid 12245757)
2. Trocme, S.D., Gleich, G.J., Kephart, G.M., et al. Eosinophil granule major basic protein inhibition of corneal epithelial wound healing. Invest. Ophthalmol. Vis. Sci. 35:3051-3056, 1994.
3. Trocme, S.D., Hallberg, C.K., Gill, K.S., et al. Effects of eosinophil granule proteins on human corneal epithelial cell viability and morphology. Invest. Ophthalmol. Vis. Sci. 38:593-599, 1997. (Pubitemid 27143129)
4. Elliott, J.F., Lin, Y., and Mizel, S.B. Induction of interleukin 2 messenger RNA inhibited by cyclosporin A. Science. 226:1439-1441, 1984. (Pubitemid 15161277)
5. Liu, J., Farmer, J.D., Jr, Lane, W.S., et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:807-815, 1991. (Pubitemid 121001714)
6. Shii, D., and Fukushima, A. Therapeutic effects and mechanisms of action of cyclosporine A ophthalmic solution in the treatment of vernal keratoconjunctivitis. Curr. Pharm. Anal. 3:213-220, 2007. (Pubitemid 47335322)
7. BenEzra, D., Pe'er, J., Brodsky, M., et al. Cyclosporine eyedrops for the treatment of severe vernal keratoconjunctivitis. Am. J. Ophthalmol. 101:278-282, 1986.
8. Secchi, A.G., Tognon, M.S., and Leonardi, A. Topical use of cyclosporine in the treatment of vernal keratoconjunctivitis. Am. J. Ophthalmol. 110:641-645, 1990.
9. Bleik, J.H., and Tabbara, K.F. Topical cyclosporine in vernal keratoconjunctivitis. Ophthalmology. 98:1679-1684, 1991.
10. Holland, E.J., Olsen, T.W., Ketcham, J.M., et al. Topical cyclosporin A in the treatment of anterior segment inflammatory disease. Cornea. 12:413-419, 1993.
11. Mendicute, J., Aranzasti, C., Eder, F., et al. Topical cyclosporin A 2% in the treatment of vernal keratoconjunctivitis. Eye. 11:75-78, 1997. (Pubitemid 27165812)
12. Gupta, V., and Sahu, P.K. Topical cyclosporin A in the management of vernal keratoconjunctivitis. Eye. 15:39-41, 2001. (Pubitemid 32258214)
13. Pucci, N., Novembre, E., Cianferoni, A., et al. Efficacy and safety of cyclosporine eyedrops in vernal keratoconjunctivitis. Ann. Allergy Asthma Immunol. 89:293-303, 2002.
14. Cetinkaya, A., Akova, Y.A., Dursun, D., et al. Topical cyclosporine in the management of shield ulcers. Cornea. 23:194-200, 2004. (Pubitemid 38292715)
15. Spadavecchia, L., Fanelli, P., Tesse, R., et al. Efficacy of 1.25% and 1% topical cyclosporine in the treatment of severe vernal keratoconjunctivitis in childhood. Pediatr. Allergy Immunol. 17:527-532, 2006. (Pubitemid 44511088)
16. Kilic, A., and Gurler, B. Topical 2% cyclosporine A in preservative- free artificial tears for the treatment of vernal keratoconjunctivitis. Can. J. Ophthalmol. 41:693-698, 2006. (Pubitemid 46113021)
17. Akpek, E.K., Dart, J.K., Watson, S., et al. A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. Ophthalmology. 111:476-482, 2004. (Pubitemid 38293102)
18. Daniell, M., Constantinou, M., Vu, H.T., et al. Randomised controlled trial of topical cyclosporin A in steroid dependent allergic conjunctivitis. Br. J. Ophthalmol. 90:461-464, 2006.
19. Ozcan, A.A., Ersoz, T.R., and Dulger, E. Management of severe allergic conjunctivitis with topical cyclosporin A 0.05% eyedrops. Cornea. 26:1035-1038, 2007. (Pubitemid 47480680)
20. Ohashi, Y., and Ohno, S. Clinical evaluation of 0.1% DE-076 (cyclosporin) ophthalmic solution in vernal keratoconjunctivitis patients unresponsive to therapy with anti-allergic ophthalmic solutions: double masked comparative study with placebo (phase II/III study). J. Eye. 24:1537-1546, 2007.
21. Uchio, E., Kimura, R., Migita, H., et al. Demographic aspects of allergic ocular diseases and evaluation of new criteria for clinical assessment of ocular allergy. Graefes Arch. Clin. Exp. Ophthalmol. 246:291-296, 2008. (Pubitemid 351149635)
22. Kuwano, M., Ibuki, H., Morikawa, N., et al. Cyclosporine A formulation affects its ocular distribution in rabbits. Pharm. Res. 19:108-111, 2002. (Pubitemid 34075115)
23. Lewis, J.M., Priddy, T., Judd, J., et al. Intraocular pressure response to topical dexamethasone as a predictor for the development of primary open-angle glaucoma. Am. J. Ophthalmol. 106:607-612, 1988. (Pubitemid 18260819)
24. Ohji, M., Kinoshita, S., Ohmi, E., et al. Marked intraocular pressure response to instillation of corticosteroids in children. Am. J. Ophthalmol. 112:450-454, 1991.
25. Wilhelmus, K.R. Indecision about corticosteroids for bacterial keratitis: an evidence-based update. Ophthalmology. 109:835-842, 2002. (Pubitemid 34465213)