Proteomic profiling of growth hormone-responsive proteins in human peripheral blood leukocytes

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 8, 2009, Pages 3038-3043

  Chung, Liping ^a   Nelson, Anne E ^b,c   Ho, Ken K Y ^b,c   Baxter, Robert C ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CALCIUM; CALGRANULIN; CALGRANULIN B; CALGRANULIN S100A12; GROWTH HORMONE; PLACEBO; PROTEIN S 100; PSORIASIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM BINDING; CATION EXCHANGE; CLINICAL RESEARCH; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNE SYSTEM; IMMUNOBLOTTING; LEUKOCYTE; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; PROTEOMICS; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; VALIDATION STUDY; WESTERN BLOTTING;

EID: 68549110222     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0778     Document Type: Article

References (43)

1. Baxter JB, Blalock JE, Weigent DA 1991 Expression of immunoreactive growth hormone in leukocytes in vivo. J Neuroimmunol 33:43-54
2. Wu H, Devi R, Malarkey WB 1996 Localization of growth hormone messenger ribonucleic acid in the human immune system: a clinical research center study. J Clin Endocrinol Metab 81:1278-1282
3. de Mello-Coelho V, Gagnerault MC, Souberbielle JC, Strasburger CJ, Savino W, Dardenne M, Postel-Vinay MC 1998 Growth hormone and its receptor are expressed in human thymic cells. Endocrinology 139:3837-3842
4. Hull KL, Thiagarajah A, Harvey S 1996 Cellular localization of growth hormone receptors/binding proteins in immune tissues. Cell Tissue Res 286:69-80
5. Baxter RC 1994 Insulin-like growth factor binding proteins in the human circulation: a review. Horm Res 42:140-144
6. Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3-34
7. Baxter RC, Martin JL 1986 Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma. J Clin Invest 78:1504-1512
8. Jeay S, Sonenshein GE, Postel-Vinay MC, Kelly PA, Baixeras E 2002 Growth hormone can act as a cytokine controlling survival and proliferation of immune cells: new insights into signaling pathways. Mol Cell Endocrinol 188:1-7
9. Welniak LA, Sun R, Murphy WJ 2002 The role of growth hormone in T-cell development and reconstitution. J Leukoc Biol 71:381-387
10. Manfredi R, Tumietto F, Azzaroli L, Zucchini A, Chiodo F, Manfredi G 1994 Growth hormone (GH) and the immune system: impaired phagocytic function in children with idiopathic GH deficiency is corrected by treatment with biosynthetic GH. J Pediatr Endocrinol 7:245-251
11. Clark R 1997 The somatogenic hormones and insulin-like growth factor-1: stimulators of lymphopoiesis and immune function. Endocr Rev 18:157-179
12. Velkeniers B, Dogusan Z, Naessens F, Hooghe R, Hooghe-Peters EL 1998 Prolactin, growth hormone and the immune system in humans. Cell Mol Life Sci 54:1102-1108
13. Kelley KW, Weigent DA, Kooijman R 2007 Protein hormones and immunity. Brain Behav Immun 21:384-392
14. Petricoin 3rd EF, Ornstein DK, Paweletz CP, Ardekani A, Hackett PS, Hitt BA, Velassco A, Trucco C, Wiegand L, Wood K, Simone CB, Levine PJ, Linehan WM, Emmert-Buck MR, Steinberg SM, Kohn EC, Liotta LA 2002 Serum proteomic patterns for detection of prostate cancer. J Natl Cancer Inst 94:1576-1578
15. Kozak KR, Amneus MW, Pusey SM, Su F, Luong MN, Luong SA, Reddy ST, Farias-Eisner R 2003 Identification of biomarkers for ovarian cancer using strong anion-exchange ProteinChips: potential use in diagnosis and prognosis. Proc Natl Acad Sci USA 100:12343-12348
16. Li J, Orlandi R, White CN, Rosenzweig J, Zhao J, Seregni E, Morelli D, Yu Y, Meng XY, Zhang Z, Davidson NE, Fung ET, Chan DW 2005 Independent validation of candidate breast cancer serum biomarkers identified by mass spectrometry. Clin Chem 51:2229-2235
17. Whelan LC, Power KA, McDowell DT, Kennedy PJ, Gallagher WM 2008 Applications of SELDI-MS technology in oncology. J Cell Mol Med 12:1535-1547
18. Chung L, Clifford D, Buckley M, Baxter RC 2006 Novel biomarkers of human growth hormone action from serum proteomic profiling using protein chip mass spectrometry. J Clin Endocrinol Metab 91:671-677
19. Hellgren G, Andersson B, Nierop AF, Dahlgren J, Hochberg Z, Albertsson-Wikland K 2008 A proteomic approach identified growth hormone-dependent nutrition markers in children with idiopathic short stature. Proteome Sci 6:35
20. Nelson AE, Meinhardt U, Hansen JL, Walker IH, Stone G, Howe CJ, Leung KC, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK 2008 Pharmacodynamics of GH abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes. J Clin Endocrinol Metab 93:2213-2222
21. Moroz OV, Antson AA, Murshudov GN, Maitland NJ, Dodson GG, Wilson KS, SkibshøjI, Lukanidin EM, Bronstein IB 2001 The three-dimensional structure of human S100A12. Acta Crystallogr D Biol Crystallogr 57:20-29
22. Gebhardt C, NémethJ, Angel P, Hess J 2006 S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 72:1622-1631
23. Vogl T, Roth J, Sorg C, Hillenkamp F, Strupat K 1999 Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. J Am Soc Mass Spectrom 10:1124-1130
24. Teigelkamp S, Bhardwaj RS, Roth J, Meinardus-Hager G, Karas M, Sorg C 1991 Calcium-dependent complex assembly of the myeloic differentiation proteins MRP-8 and MRP-14. J Biol Chem 266:13462-13467
25. de Seny D, Fillet M, Ribbens C, MaréeR, Meuwis MA, Lutteri L, Chapelle JP, Wehenkel L, Louis E, Merville MP, Malaise M 2008 Monomeric calgranulins measured by SELDI-TOF mass spectrometry and calprotectin measured by ELISA as biomarkers in arthritis. Clin Chem 54:1066-1075
26. Fanò G, Biocca S, Fulle S, Mariggiò MA, Belia S, Calissano P 1995 The S-100: a protein family in search of a function. Prog Neurobiol 46:71-82
27. Lehmann R, Melle C, Escher N, von Eggeling F 2005 Detection and identification of protein interactions of S100 proteins by ProteinChip technology. J Proteome Res 4:1717-1721
28. Odink K, Cerletti N, BrüggenJ, Clerc RG, Tarcsay L, Zwadlo G, Gerhards G, Schlegel R, Sorg C 1987 Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature 330:80-82
29. Foell D, Wittkowski H, Vogl T, Roth J 2007 S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 81:28-37
30. Yang Z, Tao T, Raftery MJ, Youssef P, Di Girolamo N, Geczy CL 2001 Proinflammatory properties of the human S100 protein S100A12. J Leukoc Biol 69:986-994
31. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J 2007 Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13:1042-1049
32. Boyd JH, Kan B, Roberts H, Wang Y, Walley KR 2008 S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res 102:1239-1246
33. Leukert N, Vogl T, Strupat K, Reichelt R, Sorg C, Roth J 2006 Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity. J Mol Biol 359:961-972
34. Robinson MJ, Hogg N 2000 A comparison of human S100A12 with MRP-14 (S100A9). Biochem Biophys Res Commun 275:865-870
35. Roth J, Vogl T, Sorg C, Sunderkötter C 2003 Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol 24:155-158
36. Ebihara T, Endo R, Kikuta H, Ishiguro N, Ma X, Shimazu M, Otoguro T, Kobayashi K 2005 Differential gene expression of S100 protein family in leukocytes from patients with Kawasaki disease. Eur J Pediatr 164:427-431
37. Slonim AE, Bulone L, Damore MB, Goldberg T, Wingertzahn MA, McKinley MJ 2000 A preliminary study of growth hormone therapy for Crohn's disease. N Engl J Med 342:1633-1637
38. Franco C, Andersson B, Lönn L, Bengtsson BA, Svensson J, Johannsson G 2007 Growth hormone reduces inflammation in postmenopausal women with abdominal obesity: a 12-month, randomized, placebo-controlled trial. J Clin Endocrinol Metab 92:2644-2647
39. Sesmilo G, Biller BM, Llevadot J, Hayden D, Hanson G, Rifai N, Klibanski A 2000 Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial. Ann Intern Med 133:111-122
40. Mealy K, Barry M, O'Mahony L, Sheehan S, Burke P, McCormack C, Whitehead AS, Bouchier-Hayes D 1998 Effects of human recombinant growth hormone (rhGH) on inflammatory responses in patients undergoing abdominal aortic aneurysm repair. Intensive Care Med 24:128-131
41. Gebhardt C, Breitenbach U, Tuckermann JP, Dittrich BT, Richter KH, Angel P 2002 Calgranulins S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner and overexpressed throughout skin carcinogenesis. Oncogene 21:4266-4276
42. Hsu K, Passey RJ, Endoh Y, Rahimi F, Youssef P, Yen T, Geczy CL 2005 Regulation of S100A8 by glucocorticoids. J Immunol 174:2318-2326
43. Kähler CM, Pischel AB, Haller T, Meierhofer C, Djanani A, Kaufmann G, Wiedermann CJ 2001 Signal transduction pathways in directed migration of human monocytes induced by human growth hormone in vitro. Int Immunopharmacol 1:1351-1361