Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination

Psychosomatic Medicine

Volumn 71, Issue 3, 2009, Pages 341-344

  Gallagher, Stephen ^a   Phillips, Anna C ^b   Drayson, Mark T ^b   Carroll, Douglas ^b  

^a STAFFORDSHIRE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Antibody response; Caregiving; Child problem behaviors; Children with developmental disabilities; Chronic stress; Influenza vaccination.

Indexed keywords

INFLUENZA VACCINE;

ADULT; ANTIBODY RESPONSE; ARTICLE; BLOOD SAMPLING; CAREGIVER; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT; CLINICAL ASSESSMENT; DEMENTIA; DEVELOPMENTAL DISORDER; FEMALE; FOLLOW UP; HUMAN; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS B; INFLUENZA VIRUS B MALAYSIA; MAJOR CLINICAL STUDY; MALE; PARENT; PRIORITY JOURNAL; STRESS; THYMUS; VIRUS STRAIN; ANTIBODY PRODUCTION; BEHAVIOR DISORDER; CHRONIC DISEASE; IMMUNOLOGY; MENTAL STRESS; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE; STATISTICS; VACCINATION;

ADULT; ANTIBODY FORMATION; CAREGIVERS; CHILD; CHILD BEHAVIOR DISORDERS; CHRONIC DISEASE; DEVELOPMENTAL DISABILITIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFLUENZA VACCINES; MALE; QUESTIONNAIRES; STRESS, PSYCHOLOGICAL; VACCINATION;

EID: 68549107768     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e31819d1910     Document Type: Article

References (33)

1. Kiecolt-Glaser JK, Glaser R, Shuttleworth EC, Dyer CS, Ogrocki P, Speicher CE. Chronic stress and immunity in family caregivers of Alzheimer's disease victims. Psychosom Med 1987;49:523-35.
2. Kiecolt-Glaser JK, Dura JR, Speicher CE, Trask OJ, Glaser R. Spousal caregivers of dementia victims: longitudinal changes in immunity and health. Psychosom Med 1991;53:345-62.
3. Mills PJ, Adler KA, Dimsdale JE, Perez CJ, Ziegler MG, Ancoli-Israel S, Patterson TL, Grant I. Vulnerable caregivers of Alzheimer disease patients have a deficit in beta 2-adrenergic receptor sensitivity and density. Am J Geriatr Psychiatry 2004;12:281-6.
4. Redwine L, Mills PJ, Sada M, Dimsdale J, Patterson T, Grant I. Differential immune cell chemotaxis responses to acute psychological stress in Alzheimer caregivers compared to non-caregiver controls. Psychosom Med 2004;66:770-5.
5. Vedhara K, Cox NK, Wilcock GK, Perks P, Hunt M, Anderson S, Lightman SL, Shanks NM. Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet 1999;353:627-31.
6. Vitaliano PP, Scanlan JM, Ochs HD, Syrjala K, Siegler IC, Snyder EA. Psychosocial stress moderates the relationship of cancer history with natural killer cell activity. Ann Behav Med 1998;20:199-208.
7. Vedhara K, Fox JD, Wang EC. The measurement of stress-related immune dysfunction in psychoneuroimmunology. Neurosci Biobehav Rev 1999;23:699-715.
8. Burns VE, Carroll D, Ring C, Drayson M. Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms. Vaccine 2003;21:2523-34.
9. Cohen S, Miller GE, Rabin BS. Psychological stress and antibody response to immunization: a critical review of the human literature. Psychosom Med 2001;63:7-18.
10. Glaser R, Sheridan J, Malarkey WB, MacCallum RC, Kiecolt-Glaser JK. Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosom Med 2000;62:804-7.
11. Kiecolt-Glaser JK, Glaser R, Gravenstein S, Malarkey WB, Sheridan J. Chronic stress alters the immune response to influenza virus vaccine in older adults. Proc Natl Acad Sci U S A 1996;93:3043-7.
12. Gallagher S, Phillips AC, Drayson MT, Carroll D. Parental caregivers of children with developmental disabilities mount a poor antibody response to pneumococcal vaccination. Brain Behav Immun 2008 Jun 30 [Epub ahead of print].
13. Vedhara K, McDermott MP, Evans TG, Treanor JJ, Plummer S, Tallon D, Cruttenden KA, Schifitto G. Chronic stress in nonelderly caregivers: psychological, endocrine and immune implications. J Psychosom Res 2002;53:1153-61.
14. Graham JE, Christian LM, Kiecolt-Glaser JK. Stress, age, and immune function: toward a lifespan approach. J Behav Med 2006;29:389-400.
15. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci U S A 2003;100:9090-5.
16. Floyd FJ, Gallagher EM. Parental stress, care demands, and use of support services for school-age children with disabilities and behavior problems. Family Relations 1997;46:359-71.
17. Hastings RP, Daley D, Burns C, Beck A. Maternal distress and expressed emotion: cross-sectional and longitudinal relationships with behavior problems of children with intellectual disabilities. Am J Ment Retard 2006;111:48-61.
18. Pinquart M, Sorensen S. Differences between caregivers and noncaregivers in psychological health and physical health: a meta-analysis. Psychol Aging 2003;18:250-67.
19. Pinquart M, Sorensen S. Associations of stressors and uplifts of caregiving with caregiver burden and depressive mood: a meta-analysis. J Gerontol B Psychol Sci Soc Sci 2003;58:P112-P128.
20. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24:385-96.
21. Goodman R. The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry 1997;38:581-6.
22. Goodman R, Scott S. Comparing the strengths and difficulties questionnaire and the child behavior checklist: is small beautiful? J Abnorm Child Psychol 1999;27:17-24.
23. Burns VE, Carroll D, Drayson M, Whitham M, Ring C. Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults. J Psychosom Res 2003;55:569-72.
24. Gallagher S, Phillips AC, Ferraro AJ, Drayson MT, Carroll D. Psychosocial factors are associated with the antibody response to both thymus-dependent and thymus-independent vaccines. Brain Behav Immun 2008;22:456-60.
25. Phillips AC, Burns VE, Carroll D, Ring C, Drayson M. The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults. Brain Behav Immun 2005;19:325-33.
26. Marmot MG, Dowey Smith G, Stansfeld S, Patel C, North F, Head J, White I, Brunner E, Feeney A. Health inequalities among British civil servants: the Whitehall II study. Lancet 1991;337:1387-93.
27. Gallagher S, Phillips AC, Ferraro AJ, Drayson MT, Carroll D. Social support is positively associated with the immunoglobulin M response to vaccination with pneumococcal polysaccharides. Biol Psychol 2008;78: 211-5.
28. Pressman SD, Cohen S, Miller GE, Barkin A, Rabin BS, Treanor JJ. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol 2005;24:297-306.
29. Miller GE, Cohen S, Pressman S, Barkin A, Rabin BS, Treanor JJ. Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body? Psychosom Med 2004;66:215-23.
30. World Influenza Centre. Influenza activity 2008. Accessed March 11, 2008.
31. Dyck DG, Short R, Vitaliano PP. Predictors of burden and infectious illness in schizophrenia caregivers. Psychosom Med 1999;61:411-9.
32. Mausbach BT, Patterson TL, Rabinowitz YG, Grant I, Schulz R. Depression and distress predict time to cardiovascular disease in dementia caregivers. Health Psychol 2007;26:539-44.
33. Garand L, Buckwalter KC, Lubaroff D, Tripp-Reimer T, Frantz RA, Ansley TN. A pilot study of immune and mood outcomes of a community-based intervention for dementia caregivers: the PLST intervention. Arch Psychiatr Nurs 2002;16:156-67.