Increased vascular endothelial growth factor expression, CD3-positive cell infiltration, and oxidative stress in premalignant lesions of the cervix

Cancer

Volumn 115, Issue 16, 2009, Pages 3680-3688

  Carrero, Yenddy ^a   Callejas, Diana ^a   Alaña, Freddy ^a   Silva, Chiquinquirá ^b   Mindiola, Raimy ^a   Mosquera, Jesús ^c  

^a UNIVERSIDAD DEL ZULIA   (Venezuela)

^b Zuila University   (Venezuela)

^c UNIVERSIDAD DEL ZULIA   (Venezuela)

Author keywords

Intraepithelial cervical neoplasia; Lymphocytes; Oxidative stress; Vascular endothelial growth factor

Indexed keywords

CD3 ANTIBODY; NITRATE; NITRITE; SUPEROXIDE; VASCULOTROPIN; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERINE CERVIX CARCINOMA IN SITU; WART VIRUS;

ALPHAPAPILLOMAVIRUS; ANTIGENS, CD3; CERVICAL INTRAEPITHELIAL NEOPLASIA; DNA, VIRAL; FEMALE; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; OXIDATIVE STRESS; PAPILLOMAVIRUS INFECTIONS; T-LYMPHOCYTES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 68549106232     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.24411     Document Type: Article

References (29)

1. Richart RM. Cervical intraepithelial neoplasia. In: Sommers SC, ed. Pathology Annual. New York, NY: Appleton-Century Crofts; 1973:301-328.
2. Apgar BS, Brotzman G. Management of cervical cytologic abnormalities. Am Fam Physician. 2004;70:1905-1916.
3. Branca M, Giorgi C, Santini D, et al. HPV-Pathogen ISS Study Group. Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high risk HPV, but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer. J Clin Pathol. 2006;59:40-47.
4. Lee JS, Kim HS, Park JT, Lee MC, Park CS. Expression of vascular endothelial growth factor in the progression of cervical neoplasia and its relation to angiogenesis and p53 status. Anal Quant Cytol Histol. 2003;25:303-311.
5. Baritaki S, Sifakis S, Huerta-Yepez S, et al. Overexpression of VEGF and TGF-beta1 mRNA in Pap smears correlates with progression of cervical intraepithelial neoplasia to cancer: implication of YY1 in cervical tumorigenesis and HPV infection. Int J Oncol. 2007;31:69-79.
6. Maluf PJ, Michelin MA, Etchebehere RM, Adad SJ, Murta EF. T lymphocytes (CD3) may participate in the recurrence of cervical intraepithelial neoplasia grade III. Arch Gynecol Obstet. 2008;278:525-530.
7. Visser J, Nijman HW, Hoogenboom BN, et al. Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia. Clin Exp Immunol. 2007;150:199-209.
8. Sgambato A, Zannoni GF, Faraglia B, et al. Decreased expression of the CDK inhibitor p27Kip1 and increased oxidative DNA damage in the multistep process of cervical carcinogenesis. Gynecol Oncol. 2004;92:776-783.
9. Briggs RT, Robinson JM, Karnovsky LM, Karnovsky MJ. Superoxide production by polymorphonuclear leukocytes. Histochemistry. 1986;84:371-378.
10. Green LC, Wagner DA, Glagowski J, Skipper PL, Wishnok JS, Tannenbaum G. Analysis of nitrate, nitrite and N nitrate in biological fluids. Anal Biochem. 1982;126:131-138.
11. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265-275.
12. Michalski B, Zieliński T, Fila A, Mazurek U, Poreba R, Wilczok T. Correlation between transcriptional activity of vascular endothelial growth factor (VEFG) and transcriptional activity of its receptors (FLT-1 and FLK-1) in low-grade squamous intraepithelial lesions (LSIL) of uterine cervix. Ginekol Pol. 2003;74:805-810.
13. Van Trappen PO, Steele D, Lowe DG, et al. Expression of vascular endothelial growth factor (VEGF)-C and VEGFD, and their receptor VEGFR-3, during different stages of cervical carcinogenesis. J Pathol. 2003;201:544-554.
14. Jung de Campos K, Focchi GR, Martins NV, Gois Speck NM, Baracat EC, Ribalta JC. Angiogenesis in squamous intraepithelial neoplasia of the uterine cervix in HIV-seropositive women. Eur J Gynaecol Oncol. 2005;26:615-618.
15. Nakamura T, Shima T, Saeki A, et al. Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer. Cancer Sci. 2007;98:874-881.
16. Davidson B, Goldberg I, Kopolovic J. Inflammatory response in cervical intraepithelial neoplasia and squamous cell carcinoma of the uterine cervix. Pathol Res Pract. 1997;193:491-495.
17. Rosini S, Caltagirone S, Tallini G, et al. Depletion of stromal and intraepithelial antigen-presenting cells in cervical neoplasia in human immunodeficiency virus infection. Hum Pathol. 1996;27:834-838.
18. Kleine-Lowinski K, Gillitzer R, Kuhne-Heid R, Rosl F. Monocyte-chemo-attractant-protein-1 (MCP-1)-gene expression in cervical intra-epithelial neoplasias and cervical carcinomas. Int J Cancer. 1999;82:6-11.
19. Naldini A, Carraro F. Role of inflammatory mediators in angiogenesis. Curr Drug Targets Inflamm Allergy. 2005;4:3-8.
20. Noonan DM, Benelli R, Albini A. Angiogenesis and cancer prevention: a vision. Recent Results Cancer Res. 2007;174: 219-224.
21. Roessner A, Kuester D, Malfertheiner P, Schneider-Stock R. Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathol Res Pract. 2008;204:511-524.
22. Fernandes PC Jr, Garcia CB, Micheli DC, Cunha FQ, Murta EF, Tavares-Murta BM. Circulating neutrophils may play a role in the host response in cervical cancer. Int J Gynecol Cancer. 2007;17:1068-1074.
23. Kim YT, Kim JW, Choi JS, Kim SH, Choi EK, Cho NH. Relation between deranged antioxidant system and cervical neoplasia. Int J Gynecol Cancer. 2004;14:889-895.
24. Maldonado PA, Negrini LA, Kaizer RR, et al. Oxidative status in patients submitted to conization and radiation treatments for uterine cervix neoplasia. Clin Chim Acta. 2006;366:174-178.
25. Tavares-Murta BM, de Resende AD, Cunha FQ, Murta EF. Local profile of cytokines and nitric oxide in patients with bacterial vaginosis and cervical intraepithelial neoplasia. Eur J Obstet Gynecol Reprod Biol. 2008;138:93-99.
26. Critchlow CW, Koutsky LA. Epidemiology of human papillomavirus infection. In: Mindel A, ed. Genital Warts: Human Papillomavirus Infection. London, UK: Edward Arnold; 1995:53-81.
27. von Knebel Doeberitz M. The role of papillomaviruses in the etiology of cervix cancer [in German]. Geburtshilfe Frauenheilkd. 1990;50:511-517.
28. Munoz M, Mendoza JA, Tellez L, et al. Deteccion de VPH-16 y 18 en muestras de cervix de mujeres que acuden a centros asistenciales de la ciudad de Merida, Venezuela. [Detection of HPV-16 and 18 in cervical samples from women of Merida, Venezuela.] Rev Biomed. 2003;14:61-68.
29. Mendoza JA, Munoz M, Vielma S, Noguera ME, Lopez M, Toro M. Infeccion cervical por el virus del papiloma humano: diagnostico por citologia y por captura de hibridos del ADN viral. [Human papilloma virus cervix infection: diagnostic by cytology and viral DNA hybrid capture.] Rev Obstet Ginecol Venez. 2000;60:103-107.