Preparation of 0.05% FK506 suspension eyedrops and its pharmacokinetics after topical ocular administration

Journal of Ocular Pharmacology and Therapeutics

Volumn 25, Issue 4, 2009, Pages 345-350

  Yuan, Jin ^a   Zhai, Jia Jie ^b   Chen, Jia Qi ^a   Ye, Cheng Tian ^a   Zhou, Shi You ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORNEA; DISPERSION; DOSE RESPONSE; DRUG HALF LIFE; DRUG STABILITY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; ENUCLEATION; FLOCCULATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RABBIT; SEDIMENTATION RATE; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION;

ADMINISTRATION, TOPICAL; ANIMALS; AQUEOUS HUMOR; CHINA; CHROMATOGRAPHY, LIQUID; CORNEA; DRUG ADMINISTRATION SCHEDULE; DRUG STABILITY; IMMUNOSUPPRESSIVE AGENTS; OPHTHALMIC SOLUTIONS; PHARMACOPOEIAS AS TOPIC; RABBITS; RHEOLOGY; TACROLIMUS; TANDEM MASS SPECTROMETRY; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 68549104185     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2008.0125     Document Type: Article

References (27)

1. Randleman, J.B., and Stulting, R.D. Prevention and treatment of corneal graft rejection: Current practice patterns (2004). Cornea. 25:286-290, 2006.
2. Williams, K.A., Esterman, A.J., Bartlett, C., et al. How effective is penetrating corneal transplantation? Factors influencing long-term outcome in multivariate analysis. Transplantation. 81:896-901, 2006. (Pubitemid 44641510)
3. Sangwan, V.S., Ramamurthy, B., Shah, U., et al. Outcome of corneal transplant rejection: A 10 year study. Clin. Exp. Ophthalmol. 33:623-627, 2005. (Pubitemid 43918403)
4. Javadi, M.A., Motlagh, B.F., Jafarinasab, M.R., et al. Outcomes of penetrating keratoplasty in keratoconus. Cornea. 24:941-946, 2005.
5. Dua, H.S., and Azuara-Blanco, A. Corneal allograft rejection: Risk factors, diagnosis, prevention and treatment. Indian J. Ophthalmol. 47:3-9, 1999.
6. Kino, T., Hatanaka, H., Hashimoto, M., et al. FK506, novel immunosuppressant isolated from a Streptomyces. 1. Fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiot. 40:1249-1255, 1987. (Pubitemid 17138109)
7. Kino, T., Imamura, M., Sakai, S., et al. Effect of FK-506 on human mixed lymphocyte reaction in vitro. Transplant. Proc. 19:36-39, 1987. (Pubitemid 17157076)
8. Oellerich, M., Armstrong, V.W., Schutz, E., et al. Therapeutic drug monitoring of cyclosporine and tacrolimus. Clin. Biochem. 31:309-316, 1998. (Pubitemid 28385227)
9. Pleyer, U., Lutz, S., Juske, W.J., et al. ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye. Invest. Ophthalmol. Vis. Sci. 34:2737-2742, 1993. (Pubitemid 23232483)
10. Mills, R.A., Jones, D.B., Winkler, C.R., et al. Topical FK-506 prevents experimental corneal allograft rejection. Cornea. 14:157-160, 1995.
11. Whitcup, S.M., Pleyer, U., Lai, J.C., et al. Topical liposome- encapsulated FK506 for the treatment of endotoxin-induced uveitis. Ocul. Immunol. Inflamm. 6:51-56, 1998. (Pubitemid 28254241)
12. Florence, A.T., and Attwood, D. Physicochemical Principles of Pharmacy. 3rd ed. London: Macmillan Press, 1998.
13. Jusko, W.J., Thomson, A.W., Fung, J., et al. Consensus document: Therapeutic monitoring of tacrolimus (FK-506). Ther. Drug Monit. 17:606-614, 1995.
14. Staatz, C.E., Taylor, P.J., and Tett, S.E. Comparison of an ELISA and an LC/MS/MS method for measuring tacrolimus concentrations and making dosage decisions in transplant recipients. Ther. Drug Monit. 24:607-615, 2002.
15. Yuan, J., Chen, J.Q., Xie, Z.Y., et al. Determination of tacrolimus in rabbit aqueous humor by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. B. 868:34-41, 2008.
16. Allen, C., Yu, Y., Maysinger, D., et al. Polycaprolactone-bpoly( ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818. Bioconjug. Chem. 9:564-572, 1998. (Pubitemid 28437000)
17. Yura, H., Yoshimura, N., Hamashima, T., et al. Synthesis and pharmacokinetics of a novel macromolecular prodrug of tacrolimus (FK506), FK506-dextran conjugate. J. Control. Release. 57(1):87-99, 1999. (Pubitemid 29005076)
18. Sakurai, E., Nozaki, M., Okabe, K., et al. Scleral plug of biodegradable polymers containing tacrolimus (FK506) for experimental uveitis. Invest. Ophthalmol. Vis. Sci. 44(11):4845-4852, 2003. (Pubitemid 37315299)
19. Fei, W.L., Chen, J.Q., Yuan, J., et al. Preliminary study of the effect of FK506 nanospheric-suspension eye drops on rejection of penetrating keratoplasty. J. Ocul. Pharmacol. Ther. 24:235-244, 2008.
20. Kassem, M.A., Abdel Rahman, A.A., Ghorab, M.M., et al. Nanosuspension as an ophthalmic delivery system for certain glucocorticoid drugs. Int. J. Pharm. 340(1-2):126-133, 2007.
21. Grove, J., Durr, M., Quint, M.-P., et al. The effect of vehicle viscosity on the ocular bioavailability of L-653.328. Int. J. Pharm. 66:23-28, 1990.
22. Wu, C., Qi, H., Chen, W., et al. Preparation and evaluation of a Carbopol® /HPMC-based in situ gelling ophthalmic system for puerarin. Yakugaku Zasshi. 127:183-1119, 2007. (Pubitemid 46089916)
23. Thomson, A.W. Interspecies comparison of the immunosuppressive efficacy and safety of FK506. Transplant. Proc. 22:100-105, 1990. (Pubitemid 20112768)
24. Fei, W., Chen, J., Pang, Z., et al. The distribution of FK506 nanoparticles in rabbit eyes. Chin. Ophthal. Res. 22:164-166, 2004. (Pubitemid 38624915)
25. Liu, Y., and Chen, J. Distribution of FK506 in ocular tissues after topical administration to rabbit eyes. Chin. J. Pract. Ophthalmol. 25:443-447, 2007.
26. Fujita, E., Teramura, Y., Mitsugi, K., et al. Absorption, distribution, and excretion of 14C-labeled tacrolimus (FK506) after a single or repeated ocular instillation in rabbits. J. Ocul. Pharmacol. Ther. 24:333-343, 2008. (Pubitemid 351735876)
27. Fujita, E., Teramura, Y., Shiraga, T., et al. Pharmacokinetics and tissue distribution of tacrolimus (FK506) after a single or repeated ocular instillation in rabbits. J. Ocul. Pharmacol. Ther. 24:309-319, 2008. (Pubitemid 351735875)