메뉴 건너뛰기




Volumn 23, Issue 3, 2009, Pages 187-196

Bevacizumab plus platinum-based chemotherapy: In advanced non-small cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; GEMCITABINE; LOW MOLECULAR WEIGHT HEPARIN; OXALIPLATIN; PACLITAXEL; PEMETREXED; PLACEBO; PLATINUM DERIVATIVE; VASCULOTROPIN;

EID: 68549097891     PISSN: 11738804     EISSN: 1179190X     Source Type: Journal    
DOI: 10.2165/00063030-200923030-00005     Document Type: Review
Times cited : (16)

References (50)
  • 1
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • Sep;
    • Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001 Sep; 2: 533-43
    • (2001) Lancet Oncol , vol.2 , pp. 533-543
    • Parkin, D.M.1
  • 2
    • 2942526896 scopus 로고    scopus 로고
    • Non-small cell lung cancer and antiangiogenic therapy: What can be expected of bevacizumab?
    • Herbst RS, Sandler AB. Non-small cell lung cancer and antiangiogenic therapy: what can be expected of bevacizumab?. Oncologist 2004; 9 Suppl. 1: 19-26
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 1 , pp. 19-26
    • Herbst, R.S.1    Sandler, A.B.2
  • 3
    • 32044446478 scopus 로고    scopus 로고
    • Targeted therapies for non-small cell lung cancer
    • Sep;
    • Spicer J, Harper P. Targeted therapies for non-small cell lung cancer. Int J Clin Pract 2005 Sep; 59 (9): 1055-62
    • (2005) Int J Clin Pract , vol.59 , Issue.9 , pp. 1055-1062
    • Spicer, J.1    Harper, P.2
  • 5
    • 42249104371 scopus 로고    scopus 로고
    • Bevacizumab in non-small cell lung cancer
    • Di Costanzo F, Mazzoni F, Micol Mela M, et al. Bevacizumab in non-small cell lung cancer. Drugs 2008; 68 (6): 737-46
    • (2008) Drugs , vol.68 , Issue.6 , pp. 737-746
    • Di Costanzo, F.1    Mazzoni, F.2    Micol Mela, M.3
  • 6
    • 33646676706 scopus 로고    scopus 로고
    • Antiangiogenic drugs in non-small cell lung cancer treatment
    • Mar;
    • Cascone T, Troiani T, Morelli MP, et al. Antiangiogenic drugs in non-small cell lung cancer treatment. Curr Opin Oncol 2006 Mar; 18 (2): 151-5
    • (2006) Curr Opin Oncol , vol.18 , Issue.2 , pp. 151-155
    • Cascone, T.1    Troiani, T.2    Morelli, M.P.3
  • 7
    • 33644998656 scopus 로고    scopus 로고
    • Bevacizumab: A review of its use in advanced colorectal cancer, breast cancer, and NSCLC
    • Lyseng-Williamson KA, Robinson DM. Bevacizumab: a review of its use in advanced colorectal cancer, breast cancer, and NSCLC. Am J Cancer 2006; 5 (1): 43-60
    • (2006) Am J Cancer , vol.5 , Issue.1 , pp. 43-60
    • Lyseng-Williamson, K.A.1    Robinson, D.M.2
  • 8
    • 20044375603 scopus 로고    scopus 로고
    • Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro
    • Wang Y, Fei D, Vanderlaan M, et al. Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro. Angiogenesis 2004; 7: 335-45
    • (2004) Angiogenesis , vol.7 , pp. 335-345
    • Wang, Y.1    Fei, D.2    Vanderlaan, M.3
  • 9
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Oct 15;
    • Presta LG, Chen H, O'Connor SJ, et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997 Oct 15; 57: 4593-9
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3
  • 10
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Feb 1;
    • Gerber H-P, Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res 2005 Feb 1; 65 (3): 671-80
    • (2005) Cancer Res , vol.65 , Issue.3 , pp. 671-680
    • Gerber, H.-P.1    Ferrara, N.2
  • 11
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001; 19 (3): 843-50
    • (2001) J Clin Oncol , vol.19 , Issue.3 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 12
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab: An Eastern Cooperative Oncology Group study
    • Mar 1;
    • Dowlati A, Gray R, Sandler AB, et al. Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab: an Eastern Cooperative Oncology Group study. Clin Cancer Res 2008 Mar 1; 14 (5): 1407-12
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3
  • 13
    • 0035253586 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data
    • Margolin K, Gordon MS, Holmgren E, et al. Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data. J Clin Oncol 2001; 19 (3): 851-6
    • (2001) J Clin Oncol , vol.19 , Issue.3 , pp. 851-856
    • Margolin, K.1    Gordon, M.S.2    Holmgren, E.3
  • 14
    • 0010779376 scopus 로고    scopus 로고
    • Population pharmacokinetic (PK) analysis of bevacizumab (BV) in cancer subjects [abstract no. 272]
    • May 12;
    • Hsei VC, Novotny WF, Margolin K, et al. Population pharmacokinetic (PK) analysis of bevacizumab (BV) in cancer subjects [abstract no. 272]. Proc Am Soc Clin Oncol 2001 May 12; 20 (Pt 1): 69a
    • (2001) Proc Am Soc Clin Oncol , vol.20 , Issue.PART 1
    • Hsei, V.C.1    Novotny, W.F.2    Margolin, K.3
  • 15
    • 68549129011 scopus 로고    scopus 로고
    • Herbst RS, Mininberg E, Henderson T, et al. Phase I/II trial evaluating blockade of tumour blood supply and tumour cell proliferation with combined bevacizumab and erlotinib HCl as targeted cancer therapy in patients with recurrent non-small cell lung cancer [abstract no. 977]. EJC Supplements 2003 Sep; 1 (5): S293. Plus poster presented at the 12th European Cancer Conference; 2003 Sep 21-23; Copenhagen
    • Herbst RS, Mininberg E, Henderson T, et al. Phase I/II trial evaluating blockade of tumour blood supply and tumour cell proliferation with combined bevacizumab and erlotinib HCl as targeted cancer therapy in patients with recurrent non-small cell lung cancer [abstract no. 977]. EJC Supplements 2003 Sep; 1 (5): S293. Plus poster presented at the 12th European Cancer Conference; 2003 Sep 21-23; Copenhagen
  • 16
    • 68549136967 scopus 로고    scopus 로고
    • Avastin 25mg/mL concentrate for solution for infusion
    • Roche Products Limited, online, Available from URL:, Accessed 2009 May 20
    • Roche Products Limited. Avastin 25mg/mL concentrate for solution for infusion. UK summary of product characteristics [online]. Available from URL: http://emc.medicines.org.uk [Accessed 2009 May 20]
    • UK summary of product characteristics
  • 17
    • 33750302638 scopus 로고    scopus 로고
    • Genentech Inc, online, Available from URL:, Accessed 2009 Jul 3
    • Genentech Inc. Avastin® (bevacizumab) US prescribing information [online]. Available from URL: http://www.gene.com/gene/products/information/pdf/ avastin-prescribing.pdf [Accessed 2009 Jul 3]
    • Avastin® (bevacizumab) US prescribing information
  • 18
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Dec 14;
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006 Dec 14; 355 (24): 2542-50
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 19
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL
    • Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL. J Clin Oncol 2009; 27 (8): 1227-34
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3
  • 20
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004; 22 (11): 2184-91
    • (2004) J Clin Oncol , vol.22 , Issue.11 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 21
    • 43049127188 scopus 로고    scopus 로고
    • Efficacy and safety of oxaliplatin and gemcitabine with bevacizumab in advanced non-small cell lung cancer
    • May;
    • Lilenbaum R, Raez L, Tseng J, et al. Efficacy and safety of oxaliplatin and gemcitabine with bevacizumab in advanced non-small cell lung cancer. J Thorac Oncol 2008 May; 3 (5): 511-5
    • (2008) J Thorac Oncol , vol.3 , Issue.5 , pp. 511-515
    • Lilenbaum, R.1    Raez, L.2    Tseng, J.3
  • 22
    • 35948932525 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus pemetrexed and carboplatin in previously untreated advanced nonsquamous non-small cell lung cancer [abstract no. 18163]
    • Dalsania CJ, Hageboutros A, Harris E, et al. Phase II trial of bevacizumab plus pemetrexed and carboplatin in previously untreated advanced nonsquamous non-small cell lung cancer [abstract no. 18163]. J Clin Oncol 2007; 25 (18 Suppl.)
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Dalsania, C.J.1    Hageboutros, A.2    Harris, E.3
  • 23
    • 35948954665 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with docetaxel and carboplatin in patients with metastatic non-small cell lung cancer [abstract no. 18098]
    • William Jr WN, Kies MS, Fossella FV, et al. Phase II study of bevacizumab in combination with docetaxel and carboplatin in patients with metastatic non-small cell lung cancer [abstract no. 18098]. J Clin Oncol 2007; 25 (18 Suppl.)
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • William Jr, W.N.1    Kies, M.S.2    Fossella, F.V.3
  • 24
    • 68549129012 scopus 로고    scopus 로고
    • Bevacizumab (Avastin®) in combination with cisplatin and docetaxel as first line treatment of patients (P) with advanced or metastatic, non squamous, non-small-cell lung cancer (NSCLC) [abstract no. 244P]
    • viii95, Sep;
    • Cobo M, Ferrer N, Paredes A, et al. Bevacizumab (Avastin®) in combination with cisplatin and docetaxel as first line treatment of patients (P) with advanced or metastatic, non squamous, non-small-cell lung cancer (NSCLC) [abstract no. 244P]. Ann Oncol 2008 Sep; 19 Suppl. 8: viii95
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 8
    • Cobo, M.1    Ferrer, N.2    Paredes, A.3
  • 25
    • 68549123730 scopus 로고    scopus 로고
    • A phase II study of oxaliplatin and pemetrexed plus bevacizumab in advanced non-squamous non-small cell lung cancer (an International Oncology Network study, #1-04-015) [abstract no. 19018]
    • 707s
    • Waples JM, Auerbach M, Steis R, et al. A phase II study of oxaliplatin and pemetrexed plus bevacizumab in advanced non-squamous non-small cell lung cancer (an International Oncology Network study, #1-04-015) [abstract no. 19018]. J Clin Oncol 2008; 26 (15 Suppl.): 707s
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Waples, J.M.1    Auerbach, M.2    Steis, R.3
  • 27
    • 68549100041 scopus 로고    scopus 로고
    • Crino L, Mezger J, Griesinger F, et al. MO19390 (SAiL): safety and efficacy of first-line bevacizumab (BV)-based therapy in advanced non-small cell lung cancer (NSCLC) [abstract no. 8043]. J Clin Oncol 2009; 27 (15 Suppl.): 417s. Plus poster presented at the American Society of Clinical Oncology (ASCO) 45th Annual Meeting; 2009 May 29-Jun 2; Orlando (FL)
    • Crino L, Mezger J, Griesinger F, et al. MO19390 (SAiL): safety and efficacy of first-line bevacizumab (BV)-based therapy in advanced non-small cell lung cancer (NSCLC) [abstract no. 8043]. J Clin Oncol 2009; 27 (15 Suppl.): 417s. Plus poster presented at the American Society of Clinical Oncology (ASCO) 45th Annual Meeting; 2009 May 29-Jun 2; Orlando (FL)
  • 28
    • 62349107301 scopus 로고    scopus 로고
    • BO17704 (AVAIL): A phase III randomised study of first-line bevacizumab combined with cisplatin/ gemcitabine (CG) in patients (pts) with advanced or recurrent non-squamous, non-small cell lung cancer (NSCLC) [abstract no. LBA1]
    • viii1, Sep;
    • Manegold C, von Pawel J, Zatloukal P, et al. BO17704 (AVAIL): a phase III randomised study of first-line bevacizumab combined with cisplatin/ gemcitabine (CG) in patients (pts) with advanced or recurrent non-squamous, non-small cell lung cancer (NSCLC) [abstract no. LBA1]. Ann Oncol 2008 Sep; 19 Suppl. 8: viii1
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 8
    • Manegold, C.1    von Pawel, J.2    Zatloukal, P.3
  • 29
    • 68549098283 scopus 로고    scopus 로고
    • Sandler AB, Kong G, Strickland D, et al. Treatment outcomes by tumor histology in Eastern Cooperative Group (ECOG) study E4599 of bevacizumab (BV) with paclitaxel/carboplatin (PC) for advanced non-small cell lung cancer (NSCLC) [abstractno. 133]. Journal ofThoracic Oncology 2008; 3 (11 Suppl. 4): S283. Plus poster presented at the International Association for the Study of Lung Cancer (IASLC) Chicago Multidisciplinary Symposium in Thoracic Oncology; 2008 Nov 13-15; Chicago (IL)
    • Sandler AB, Kong G, Strickland D, et al. Treatment outcomes by tumor histology in Eastern Cooperative Group (ECOG) study E4599 of bevacizumab (BV) with paclitaxel/carboplatin (PC) for advanced non-small cell lung cancer (NSCLC) [abstractno. 133]. Journal ofThoracic Oncology 2008; 3 (11 Suppl. 4): S283. Plus poster presented at the International Association for the Study of Lung Cancer (IASLC) Chicago Multidisciplinary Symposium in Thoracic Oncology; 2008 Nov 13-15; Chicago (IL)
  • 30
    • 37849052774 scopus 로고    scopus 로고
    • Outcomes for elderly, advanced-stage non-small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: Analysis of Eastern Cooperative Oncology Group trial 4599
    • Jan 1;
    • Ramalingam SS, Dahlberg SE, Langer CJ, et al. Outcomes for elderly, advanced-stage non-small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group trial 4599. J Clin Oncol 2008 Jan 1; 26 (1): 60-5
    • (2008) J Clin Oncol , vol.26 , Issue.1 , pp. 60-65
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3
  • 31
    • 34547485062 scopus 로고    scopus 로고
    • Examining the cost and cost-effectiveness of adding bevacizumab to carboplatin and paclitaxel in advanced non-small cell lung cancer [abstract no. 6057]
    • 314s
    • Grusenmeyer PA, Gralla RJ. Examining the cost and cost-effectiveness of adding bevacizumab to carboplatin and paclitaxel in advanced non-small cell lung cancer [abstract no. 6057]. J Clin Oncol 2006; 24 (18 Suppl.): 314s
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Grusenmeyer, P.A.1    Gralla, R.J.2
  • 32
    • 68549133628 scopus 로고    scopus 로고
    • Leighl NB, Zatloukal P, Mezger J, et al. Efficacy and safety of first-line bevacizumab (Bv) and cisplatin/gemcitabine (CG) in elderly patients (pts) with advanced non-small cell lung cancer (NSCLC) in the BO17704 study [abstract no. 8050]. J Clin Oncol 2009; 27 (15 Suppl.): 419s. Plus poster presented at the American Society of Clinical Oncology (ASCO) 45th Annual Meeting; 2009May 29-Jun 2; Orlando (FL)
    • Leighl NB, Zatloukal P, Mezger J, et al. Efficacy and safety of first-line bevacizumab (Bv) and cisplatin/gemcitabine (CG) in elderly patients (pts) with advanced non-small cell lung cancer (NSCLC) in the BO17704 study [abstract no. 8050]. J Clin Oncol 2009; 27 (15 Suppl.): 419s. Plus poster presented at the American Society of Clinical Oncology (ASCO) 45th Annual Meeting; 2009May 29-Jun 2; Orlando (FL)
  • 33
    • 74949133713 scopus 로고    scopus 로고
    • Bevacizumab (Bv) single-agent maintenance following Bv-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC): Results from an exploratory analysis of the AVAiL study [abstract no. e19001]
    • Mezger J, von Pawel J, Reck M. Bevacizumab (Bv) single-agent maintenance following Bv-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC): results from an exploratory analysis of the AVAiL study [abstract no. e19001]. J Clin Oncol 2009; 27 (15 Suppl.)
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Mezger, J.1    von Pawel, J.2    Reck, M.3
  • 34
    • 68549085569 scopus 로고    scopus 로고
    • A cost analysis of treatment with bevacizumab plus cisplatin and gemcitabine (BCG) versus cetuximab plus vinorelbine and cisplatin (CVC) in patients with advanced or recurrent non-small cell lung cancer (NSCLC) in Germany [abstract no. e17553]
    • Heigener DF, Wiesner C, Aultman R. A cost analysis of treatment with bevacizumab plus cisplatin and gemcitabine (BCG) versus cetuximab plus vinorelbine and cisplatin (CVC) in patients with advanced or recurrent non-small cell lung cancer (NSCLC) in Germany [abstract no. e17553]. J Clin Oncol 2009; 27 (15 Suppl.)
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Heigener, D.F.1    Wiesner, C.2    Aultman, R.3
  • 35
    • 68549140425 scopus 로고    scopus 로고
    • Analysis of the costs of bevacizumab plus cisplatin and gemcitabine versus cetuximab plus vinorelbine and cisplatin in patients with advanced non-small cell lung cancer (NSCLC) in France: Results from a cost modelling study [abstract no. e17560]
    • Chouaid C, Vergnenègre A, Florentin V, et al. Analysis of the costs of bevacizumab plus cisplatin and gemcitabine versus cetuximab plus vinorelbine and cisplatin in patients with advanced non-small cell lung cancer (NSCLC) in France: results from a cost modelling study [abstract no. e17560]. J Clin Oncol 2009; 27 (15 Suppl.)
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Chouaid, C.1    Vergnenègre, A.2    Florentin, V.3
  • 36
    • 68549135454 scopus 로고    scopus 로고
    • The cost savings associated with bevacizumab plus cisplatin and gemcitabine (bevacizumab-based therapy) compared with cetuximab plus vinorelbine and cisplatin (cetuximab-based therapy) in patients with advanced or recurrent non-small cell lung cancer (NSCLC) across four European countries [abstract no. PCN29]
    • Nuijten M, Chouaid C, Vergnenegre A. The cost savings associated with bevacizumab plus cisplatin and gemcitabine (bevacizumab-based therapy) compared with cetuximab plus vinorelbine and cisplatin (cetuximab-based therapy) in patients with advanced or recurrent non-small cell lung cancer (NSCLC) across four European countries [abstract no. PCN29]. Value Health 2009; 12 (3): A41
    • (2009) Value Health , vol.12 , Issue.3
    • Nuijten, M.1    Chouaid, C.2    Vergnenegre, A.3
  • 37
    • 77956040558 scopus 로고    scopus 로고
    • The costs of treating patients with advanced or recurrent non-small cell lung cancer (NSCLC) with bevacizumab plus cisplatin and gemcitabine compared with pemetrexed plus cisplatin in induction and maintenance therapy in Germany and Italy [abstract no. PCN30]
    • Nuijten M. The costs of treating patients with advanced or recurrent non-small cell lung cancer (NSCLC) with bevacizumab plus cisplatin and gemcitabine compared with pemetrexed plus cisplatin in induction and maintenance therapy in Germany and Italy [abstract no. PCN30]. Value Health 2009; 12 (3): A41
    • (2009) Value Health , vol.12 , Issue.3
    • Nuijten, M.1
  • 38
    • 68549130968 scopus 로고    scopus 로고
    • Risk of symptomatic central nervous system (CNS) progression and secondary hemorrhage in patients with non-squamous non-small cell lung cancer (NSCLC) receiving bevacizumab-based first-line therapy [poster no. 51C]
    • May 30-Jun 3; Chicago IL
    • Archer V, Reck M, Sandler A, et al. Risk of symptomatic central nervous system (CNS) progression and secondary hemorrhage in patients with non-squamous non-small cell lung cancer (NSCLC) receiving bevacizumab-based first-line therapy [poster no. 51C]. American Society of Clinical Oncology (ASCO) 44th Annual Meeting; 2008 May 30-Jun 3; Chicago (IL)
    • (2008) American Society of Clinical Oncology (ASCO) 44th Annual Meeting
    • Archer, V.1    Reck, M.2    Sandler, A.3
  • 39
    • 68549125566 scopus 로고    scopus 로고
    • Hirsh V, Ramlau R, von Pawel J, et al. Final safety results of BO17704 (AVAiL): a phase III randomised study of first-line bevacizumab (Bv) and cisplatin/gemcitabine (CG) in patients (pts) with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) [abstract no. 8039]. J Clin Oncol 2009; 27 (15 Suppl.): 416s. Plus poster presented at the American SocietyofClinical Oncology(ASCO)45th Annual Meeting; 2009 May 29-Jun2; Orlando (FL)
    • Hirsh V, Ramlau R, von Pawel J, et al. Final safety results of BO17704 (AVAiL): a phase III randomised study of first-line bevacizumab (Bv) and cisplatin/gemcitabine (CG) in patients (pts) with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) [abstract no. 8039]. J Clin Oncol 2009; 27 (15 Suppl.): 416s. Plus poster presented at the American SocietyofClinical Oncology(ASCO)45th Annual Meeting; 2009 May 29-Jun2; Orlando (FL)
  • 40
    • 68549106396 scopus 로고    scopus 로고
    • Safety of first-line bevacizumab (BV) plus chemotherapy in elderly patients (pts) with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL) study [poster no. 240P]
    • Sep 12-16; Stockholm
    • Jager E, Wu Y, Mezger J, et al. Safety of first-line bevacizumab (BV) plus chemotherapy in elderly patients (pts) with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL) study [poster no. 240P]. 33rd European Society for Medical Oncology (ESMO) Congress; 2008 Sep 12-16; Stockholm
    • (2008) 33rd European Society for Medical Oncology (ESMO) Congress
    • Jager, E.1    Wu, Y.2    Mezger, J.3
  • 41
    • 68549091097 scopus 로고    scopus 로고
    • Safety of first-line bevacizumab-based therapy with concomitant cardiovascular or anticoagulation medication in advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) in MO19390 (SAiL) [poster no. 42D]. The MO19390 (SAiL) study group
    • May 30-Jun 3; Chicago IL
    • Griesinger F, Laskin J, Pavlakis N. Safety of first-line bevacizumab-based therapy with concomitant cardiovascular or anticoagulation medication in advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) in MO19390 (SAiL) [poster no. 42D]. The MO19390 (SAiL) study group. American Society of Clinical Oncology (ASCO) 44th Annual Meeting; 2008 May 30-Jun 3; Chicago (IL)
    • (2008) American Society of Clinical Oncology (ASCO) 44th Annual Meeting
    • Griesinger, F.1    Laskin, J.2    Pavlakis, N.3
  • 42
    • 68549094680 scopus 로고    scopus 로고
    • Effects of diagnostic method and surgery on safety of first-line bevacizumab plus chemotherapy in advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL) [poster no. 43E]. The MO19390 (SAiL) study group
    • May 30-June 3; Chicago IL
    • Tsai G-M, Thatcher N. Effects of diagnostic method and surgery on safety of first-line bevacizumab plus chemotherapy in advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL) [poster no. 43E]. The MO19390 (SAiL) study group. American Society of Clinical Oncology (ASCO) 44th Annual Meeting; 2008 May 30-June 3; Chicago (IL)
    • (2008) American Society of Clinical Oncology (ASCO) 44th Annual Meeting
    • Tsai, G.-M.1    Thatcher, N.2
  • 43
    • 68549121233 scopus 로고    scopus 로고
    • MO19390 (SAiL): Incidence of thromboembolic events and congestive heart failure with first-line bevacizumab (Bv)-based therapy in advanced non-small cell lung cancer (NSCLC) [abstract no. e19003]
    • Pavlakis N, Hirsh V, Reck M, et al. MO19390 (SAiL): incidence of thromboembolic events and congestive heart failure with first-line bevacizumab (Bv)-based therapy in advanced non-small cell lung cancer (NSCLC) [abstract no. e19003]. J Clin Oncol 2009; 27 (15 Suppl.)
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Pavlakis, N.1    Hirsh, V.2    Reck, M.3
  • 44
    • 68549106395 scopus 로고    scopus 로고
    • MO19390 (SAiL): Incidence and management of hypertension (HTN) during bevacizumab (Bv)-based first-line therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) [abstract no. e19002]
    • Garrido Lopez P, Laskin J, Jiang G, et al. MO19390 (SAiL): incidence and management of hypertension (HTN) during bevacizumab (Bv)-based first-line therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) [abstract no. e19002]. J Clin Oncol 2009; 27 (15 Suppl.)
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Garrido Lopez, P.1    Laskin, J.2    Jiang, G.3
  • 45
    • 71649086292 scopus 로고    scopus 로고
    • Preliminary safety and effectiveness of bevacizumab (BV) based treatment in subpopulations of patients (pts) with non-small cell lung cancer (NSCLC) from the ARIES study: A bevacizumab (BV) treatment observational cohort study (OCS) [abstract no. 8040]
    • 416s
    • Fischbach NA, Spigel D, Brahmer J, et al. Preliminary safety and effectiveness of bevacizumab (BV) based treatment in subpopulations of patients (pts) with non-small cell lung cancer (NSCLC) from the ARIES study: a bevacizumab (BV) treatment observational cohort study (OCS) [abstract no. 8040]. J Clin Oncol 2009; 27 (15 Suppl.): 416s
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Fischbach, N.A.1    Spigel, D.2    Brahmer, J.3
  • 46
    • 68549133630 scopus 로고    scopus 로고
    • Retrospective study of clinical and radiographic risk factors associated with early-onset, severe pulmonary hemorrhage in bevacizumab-treated patients with advanced non-small cell lung cancer (NSCLC) [poster no 8074]
    • May 30-Jun 3; Chicago IL
    • Sandler A, Archer V, Hirsh V, et al. Retrospective study of clinical and radiographic risk factors associated with early-onset, severe pulmonary hemorrhage in bevacizumab-treated patients with advanced non-small cell lung cancer (NSCLC) [poster no 8074]. American Society ofClinical Oncology (ASCO) 44th Annual Meeting; 2008 May 30-Jun 3; Chicago (IL)
    • (2008) American Society ofClinical Oncology (ASCO) 44th Annual Meeting
    • Sandler, A.1    Archer, V.2    Hirsh, V.3
  • 47
    • 74649085057 scopus 로고    scopus 로고
    • Safety of bevacizumab in patients with metastases tothe central nervous system [abstract no. 2007].J
    • 88s
    • Rohr UP, Augustus S, Lasserre SF, et al. Safety of bevacizumab in patients with metastases tothe central nervous system [abstract no. 2007].J Clin Oncol 2009; 27 (15 Suppl.): 88s
    • (2009) Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Rohr, U.P.1    Augustus, S.2    Lasserre, S.F.3
  • 48
    • 68549087396 scopus 로고    scopus 로고
    • Acceptable safety ofbevacizumab therapy in patients with brain metastases due to non-small cell lung cancer [poster no. 8043]
    • May 30-Jun 3; Chicago IL
    • Akerley W, Langer C, Oh Y,et al. Acceptable safety ofbevacizumab therapy in patients with brain metastases due to non-small cell lung cancer [poster no. 8043]. American Society of Clinical Oncology (ASCO) 44th Annual Meeting; 2008 May 30-Jun 3; Chicago (IL)
    • (2008) American Society of Clinical Oncology (ASCO) 44th Annual Meeting
    • Akerley, W.1    Langer, C.2    Oh, Y.3
  • 49
    • 68549102058 scopus 로고    scopus 로고
    • F. Hoffmann-La Roche Ltd. Avastin label updated reflecting confidence in safety profile: contraindication for patients with untreated brain metastases removed [media release]. Available from URL: http://www.roche.comhttp:// www.roche.com/investors/ir-update/inv-update-2009-03-31.htm [Accessed 2009 Jul 3]
    • F. Hoffmann-La Roche Ltd. Avastin label updated reflecting confidence in safety profile: contraindication for patients with untreated brain metastases removed [media release]. Available from URL: http://www.roche.comhttp:// www.roche.com/investors/ir-update/inv-update-2009-03-31.htm [Accessed 2009 Jul 3]
  • 50
    • 63849332335 scopus 로고    scopus 로고
    • Emerging safety data for bevacizumab in advanced non-small-cell lung cancer
    • Hirsh V. Emerging safety data for bevacizumab in advanced non-small-cell lung cancer. Clinical Lung Cancer 2008; 9 Suppl. 2: S62-70
    • (2008) Clinical Lung Cancer , vol.9 , Issue.SUPPL. 2
    • Hirsh, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.