Pharmacokinetics and pharmacodynamics of anastrozole in pubertal boys with recent-onset gynecomastia

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 8, 2009, Pages 2975-2978

  Mauras, Nelly ^a   Bishop, Kim ^a   Merinbaum, Debbie ^a   Emeribe, Ugochi ^b   Agbo, Felix ^b   Lowe, Elizabeth ^b  

^a NEMOURS CHILDREN S CLINIC   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANASTROZOLE; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; BODY MASS; BREAST; CLINICAL ARTICLE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMUR EPIPHYSIS; GASTROENTERITIS; GYNECOMASTIA; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT; PRIORITY JOURNAL; PUBERTY; RESPIRATORY TRACT DISEASE; SIDE EFFECT; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT OUTCOME; ULTRASOUND;

EID: 68549090628     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-2527     Document Type: Article

References (18)

1. Reiter EO, Norjavaara E 2005 Testotoxicosis: current viewpoint. Pediatr Endocrinol Rev 3:77-86
2. Plourde PV, Reiter EO, Jou HC, Desrochers PE, Rubin SD, Bercu BB, Diamond Jr FB, Backeljauw PF 2004 Safety and efficacy of anastrozole for the treatment of pubertal gynecomastia: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 89:4428-4433
3. Hero M, Norjavaara E, Dunkel L 2005 Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial. J Clin Endocrinol Metab 90:6396-6402
4. Wickman S, Sipilä I, Ankarberg-Lindgren C, Norjavaara E, Dunkel L 2001 A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomized controlled trial. Lancet 357:1743-1748
5. Mauras N, Gonzalez de Pijem L, Hsiang HY, Desrosiers P, Rapaport R, Schwartz ID, Klein KO, Singh RJ, Miyamoto A, Bishop K 2008 Anastrozole increases predicted adult height of short adolescent males treated with growth hormone: a randomized, placebo-controlled, multicenter trial for one to three years. J Clin Endocrinol Metab 93:823-831
6. Mauras N, Lima J, Patel D, Rini A, DiSalle E, Kwok A, Lippe B 2003 Pharmacokinetics and dose finding of a potent aromatase inhibitor, Aromasin (exemestane) in young males. J Clin Endocrinol Metab [Erratum (2004) 89:732] 88:5951-5956
7. Poulsen HS 1977 Demonstration of hormonal sensitivity in gynaecomastic tissue by thymidine incorporation in vitro. Acta Pathol Microbiol Scand 85:19-24
8. Nicolis GL, Modlinger RS, Gabrilove JL 1971 A study of the histopathology of human gynecomastia. J Clin Endocrinol Metab 32:173-178
9. Plourde PV, Dyroff M, Dukes M 1994 Arimidex: a potent and selective fourth-generation aromatase inhibitor. Breast Cancer Res Treat 30:103-111
10. Lønning PE, Geisler J, Dowsett M 1998 Pharmacological and clinical profile of anastrozole. Breast Cancer Res Treat 49(Suppl 1):S53-S57
11. Geisler J, King N, Dowsett M, Ottestad L, Lundgren S, Walton P, Kormeset PO, Lønning PE 1996 Influence of anastrozole (Arimidex), a selective, nonsteroidal aromatase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postmenopausal women with breast cancer. Br J Cancer 74:1286-1291
12. Tredway DR, Buraglio M, Hemsey G, Denton G 2004 A phase I study of the pharmacokinetics, pharmacodynamics, and safety of single- and multiple-dose anastrozole in healthy, premenopausal female volunteers. Fertil Steril 82:1587-1593
13. Mauras N, O'Brien KO, Klein KO, Hayes V 2000 Estrogen suppression in males: metabolic effects. J Clin Endocrinol Metab 85:2370-2377
14. Mauras N, Welch S, Rini A, Klein KO 2004 An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys. J Pediatr Endocrinol Metab 17:1597-1606
15. Santen RJ, Lee JS, Wang S, Demers LM, Mauras N, Wang H, Singh R 2008 Potential role of ultra-sensitive estradiol assays in estimating the risk of breast cancer and fractures. Steroids 73:1318-1321
16. Shozu M, Sebastian S, Takayama K, Hsu WT, Schultz RA, Neely K, Bryant M, Bulun SE 2003 Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. N Engl J Med 348:1855-1865
17. Braunstein GD 2007 Gynecomastia. N Engl J Med 357:1229-1237
18. Bannayan GA, Hajdu SI 1972 Gynecomastia: clinicopathologic study of 351 cases. Am J Clin Pathol 57:431-437