-
1
-
-
26444453262
-
Mitochondrial ceramide and the induction of apoptosis
-
Siskind LJ. Mitochondrial ceramide and the induction of apoptosis. J Bioenerg Biomembr 2005; 37: 143-53.
-
(2005)
J Bioenerg Biomembr
, vol.37
, pp. 143-153
-
-
Siskind, L.J.1
-
2
-
-
33845977959
-
Mitochondrial membrane permeabilization in cell death
-
Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev 2007; 87: 99-163.
-
(2007)
Physiol Rev
, vol.87
, pp. 99-163
-
-
Kroemer, G.1
Galluzzi, L.2
Brenner, C.3
-
3
-
-
33745019149
-
Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells
-
Landau Z, Forti E, Alcaly M, Birk RZ. Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells. Apoptosis 2006; 11: 717-24.
-
(2006)
Apoptosis
, vol.11
, pp. 717-724
-
-
Landau, Z.1
Forti, E.2
Alcaly, M.3
Birk, R.Z.4
-
4
-
-
41349110485
-
Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/ FasL system and activation of caspases in AGS human gastric adenocarcinoma cells
-
Kwon JI, Kim GY, Park KY, Ryu CH, Choi YH. Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/ FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. J Med Food 2008; 11: 1-8.
-
(2008)
J Med Food
, vol.11
, pp. 1-8
-
-
Kwon, J.I.1
Kim, G.Y.2
Park, K.Y.3
Ryu, C.H.4
Choi, Y.H.5
-
5
-
-
33746912767
-
The permeability transition pore complex in cancer cell death
-
Brenner C, Grimm S. The permeability transition pore complex in cancer cell death. Oncogene 2006; 25: 4744-56.
-
(2006)
Oncogene
, vol.25
, pp. 4744-4756
-
-
Brenner, C.1
Grimm, S.2
-
6
-
-
34247549679
-
The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis
-
Rasola A, Bernardi P. The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis 2007; 12: 815-33.
-
(2007)
Apoptosis
, vol.12
, pp. 815-833
-
-
Rasola, A.1
Bernardi, P.2
-
7
-
-
0031590634
-
Fatty acid-promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier
-
Schönfeld P, Bohenensack R. Fatty acid-promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier. FEBS Lett 1997; 420: 167-70.
-
(1997)
FEBS Lett
, vol.420
, pp. 167-170
-
-
Schönfeld, P.1
Bohenensack, R.2
-
8
-
-
0032803798
-
Palmitate induces apoptosis via a direct effect on mitochondria
-
de Pablo MA, Susin SA, Jacotot E, et al. Palmitate induces apoptosis via a direct effect on mitochondria. Apoptosis 1999; 4: 81-7.
-
(1999)
Apoptosis
, vol.4
, pp. 81-87
-
-
de Pablo, M.A.1
Susin, S.A.2
Jacotot, E.3
-
9
-
-
0034612153
-
Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: Prevention by cyclosporin A
-
Kong JY, Rabkin SW. Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin A. Biochim Biophys Acta 2000; 1485: 45-55.
-
(2000)
Biochim Biophys Acta
, vol.1485
, pp. 45-55
-
-
Kong, J.Y.1
Rabkin, S.W.2
-
10
-
-
0036044373
-
Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death
-
Bernardi P, Penzo D, Wojtczak L. Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death. Vitam Horm 2002; 65: 97-126.
-
(2002)
Vitam Horm
, vol.65
, pp. 97-126
-
-
Bernardi, P.1
Penzo, D.2
Wojtczak, L.3
-
11
-
-
0036233315
-
Mechanisms of lipoapoptosis: Implications for human heart disease
-
Listenberger LL, Schaffer JE. Mechanisms of lipoapoptosis: implications for human heart disease. Trends Cardiovasc Med 2002; 12: 134-8.
-
(2002)
Trends Cardiovasc Med
, vol.12
, pp. 134-138
-
-
Listenberger, L.L.1
Schaffer, J.E.2
-
12
-
-
46449087496
-
Fatty acids as modulators of the cellular production of reactive oxygen species
-
Schönfeld P, Wojtczak L. Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radic Biol Med 2008; 45: 231-41.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 231-241
-
-
Schönfeld, P.1
Wojtczak, L.2
-
13
-
-
0036139671
-
The mitochondrial uncoupling protein UCP1: A gated pore
-
Arechaga I, Ledesma A, Rial E. The mitochondrial uncoupling protein UCP1: a gated pore. IUBMB Life 2001; 52: 165-73.
-
(2001)
IUBMB Life
, vol.52
, pp. 165-173
-
-
Arechaga, I.1
Ledesma, A.2
Rial, E.3
-
15
-
-
0031013623
-
Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
-
Halestrap AP, Woodfield KY, Connern CP. Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J Biol Chem 1997; 272: 3346-54.
-
(1997)
J Biol Chem
, vol.272
, pp. 3346-3354
-
-
Halestrap, A.P.1
Woodfield, K.Y.2
Connern, C.P.3
-
16
-
-
0342602044
-
Deletion of amino acids 261-269 in the brown fat uncoupling protein converts the carrier into a pore
-
González-Barroso MM, Fleury C, Levi-Meyrueis C, Zaragoza P, Bouillaud F, Rial E. Deletion of amino acids 261-269 in the brown fat uncoupling protein converts the carrier into a pore. Biochemistry 1997; 36: 10930-5.
-
(1997)
Biochemistry
, vol.36
, pp. 10930-10935
-
-
González-Barroso, M.M.1
Fleury, C.2
Levi-Meyrueis, C.3
Zaragoza, P.4
Bouillaud, F.5
Rial, E.6
-
17
-
-
0242497235
-
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
-
Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trézéguet V, Lauquin GJM, Brandolin G. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature 2003; 426: 39-44.
-
(2003)
Nature
, vol.426
, pp. 39-44
-
-
Pebay-Peyroula, E.1
Dahout-Gonzalez, C.2
Kahn, R.3
Trézéguet, V.4
Lauquin, G.J.M.5
Brandolin, G.6
-
18
-
-
0005937584
-
Influence of potassium and other alkali ions on respiration of mitochondria
-
Pressman BC, Lardy HA. Influence of potassium and other alkali ions on respiration of mitochondria. J Biol Chem 1952; 197: 547-56.
-
(1952)
J Biol Chem
, vol.197
, pp. 547-556
-
-
Pressman, B.C.1
Lardy, H.A.2
-
19
-
-
0000848071
-
Effect of surface active agents on the latent ATPase of mitochondria
-
Pressman BC, Lardy HA. Effect of surface active agents on the latent ATPase of mitochondria. Biochim Biophys Acta 1956; 21: 458-66.
-
(1956)
Biochim Biophys Acta
, vol.21
, pp. 458-466
-
-
Pressman, B.C.1
Lardy, H.A.2
-
20
-
-
0027384310
-
Effect of fatty acids on energy coupling processes in mitochondria
-
Wojtczak L, Schönfeld P. Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta 1993; 1183: 41-57.
-
(1993)
Biochim Biophys Acta
, vol.1183
, pp. 41-57
-
-
Wojtczak, L.1
Schönfeld, P.2
-
21
-
-
0024277366
-
Carboxyatractylate inhibits the uncoupling effect of free fatty acids
-
Andreyev AY, Bondareva TO, Dedukhova VI, Mokhova EN, Skulachev VP, Volkov NI. Carboxyatractylate inhibits the uncoupling effect of free fatty acids. FEBS Lett 1988; 226: 265-9.
-
(1988)
FEBS Lett
, vol.226
, pp. 265-269
-
-
Andreyev, A.Y.1
Bondareva, T.O.2
Dedukhova, V.I.3
Mokhova, E.N.4
Skulachev, V.P.5
Volkov, N.I.6
-
22
-
-
0025930608
-
Fatty acid circuit as a physiological of uncoupling of oxidative phosphorylation
-
Skulachev VP. Fatty acid circuit as a physiological of uncoupling of oxidative phosphorylation. FEBS Lett 1991; 294: 158-62.
-
(1991)
FEBS Lett
, vol.294
, pp. 158-162
-
-
Skulachev, V.P.1
-
23
-
-
0027945163
-
The reconstituted ADP/ATP carrier can mediate H+ transport by free fatty acids, which is furhter stimulated by mersalyl
-
Brustovetsky N, Klingenberg M. The reconstituted ADP/ATP carrier can mediate H+ transport by free fatty acids, which is furhter stimulated by mersalyl. J Biol Chem 1994; 269: 27329-36.
-
(1994)
J Biol Chem
, vol.269
, pp. 27329-27336
-
-
Brustovetsky, N.1
Klingenberg, M.2
-
24
-
-
0033387853
-
Anion carriers in fatty acid-mediated physiological uncoupling
-
Skulachev VP. Anion carriers in fatty acid-mediated physiological uncoupling. J Bioenerg Biomembr 1999; 31: 431-45.
-
(1999)
J Bioenerg Biomembr
, vol.31
, pp. 431-445
-
-
Skulachev, V.P.1
-
25
-
-
1242317666
-
The mitochondrial transporter family (SLC25): Physiological and pathological implications
-
Palmieri F. The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch 2004; 447: 689-709.
-
(2004)
Pflugers Arch
, vol.447
, pp. 689-709
-
-
Palmieri, F.1
-
28
-
-
33745605166
-
Uncoupling proteins: A role in protection against reactive oxygen species-or not?
-
Cannon B, Shabalina IG, Kramarova TV, Petrovic N, Nedergaard J. Uncoupling proteins: a role in protection against reactive oxygen species-or not? Biochim Biophys Acta 2006; 1757: 449-58.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 449-458
-
-
Cannon, B.1
Shabalina, I.G.2
Kramarova, T.V.3
Petrovic, N.4
Nedergaard, J.5
-
29
-
-
33846813359
-
Uncoupling protein-3: Clues in an ongoing mitochondrial mystery
-
Bézaire V, Seifert EL, Harper ME. Uncoupling protein-3: clues in an ongoing mitochondrial mystery. FASEB J 2007; 21: 312-24.
-
(2007)
FASEB J
, vol.21
, pp. 312-324
-
-
Bézaire, V.1
Seifert, E.L.2
Harper, M.E.3
-
30
-
-
34948890043
-
Mitochondrial uncoupling proteins. What is their physiological role?
-
Echtay KS. Mitochondrial uncoupling proteins. What is their physiological role? Free Radic Biol Med 2007; 43: 1351-71.
-
(2007)
Free Radic Biol Med
, vol.43
, pp. 1351-1371
-
-
Echtay, K.S.1
-
31
-
-
37549064399
-
Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals
-
Saito S, Saito CT, Shingai R. Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals. Gene 2008; 408: 37-44.
-
(2008)
Gene
, vol.408
, pp. 37-44
-
-
Saito, S.1
Saito, C.T.2
Shingai, R.3
-
32
-
-
0021322138
-
Thermogenic mechanisms in brown fat
-
Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev 1984; 64: 1-64.
-
(1984)
Physiol Rev
, vol.64
, pp. 1-64
-
-
Nicholls, D.G.1
Locke, R.M.2
-
33
-
-
0035283206
-
Physiological regulation of the transport activity in the uncoupling proteins UCP1 and UCP2
-
Rial E, González-Barroso MM. Physiological regulation of the transport activity in the uncoupling proteins UCP1 and UCP2. Biochim Biophys Acta 2001; 1504: 70-81.
-
(2001)
Biochim Biophys Acta
, vol.1504
, pp. 70-81
-
-
Rial, E.1
González-Barroso, M.M.2
-
34
-
-
0022461282
-
Quantification of fatty acid activation of the uncoupling protein in adipocytes and mitochondria from guinea-pig
-
Cunningham S, Wiesinger H, Nicholls DG. Quantification of fatty acid activation of the uncoupling protein in adipocytes and mitochondria from guinea-pig. Eur J Biochem 1986; 157: 415-20.
-
(1986)
Eur J Biochem
, vol.157
, pp. 415-420
-
-
Cunningham, S.1
Wiesinger, H.2
Nicholls, D.G.3
-
35
-
-
0343900275
-
The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter
-
González-Barroso MM, Fleury C, Bouillaud F, Nicholls DG, Rial E. The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter. J Biol Chem 1998; 273: 15528-32.
-
(1998)
J Biol Chem
, vol.273
, pp. 15528-15532
-
-
González-Barroso, M.M.1
Fleury, C.2
Bouillaud, F.3
Nicholls, D.G.4
Rial, E.5
-
36
-
-
1042286448
-
Alkylsulfonates activate the uncoupling protein UCP1: Implications for the transport mechanism
-
Rial E, Aguirregoitia E, Jiménez-Jiménez J, Ledesma A. Alkylsulfonates activate the uncoupling protein UCP1: implications for the transport mechanism. Biochim Biophys Acta 2004; 1608: 122-30.
-
(2004)
Biochim Biophys Acta
, vol.1608
, pp. 122-130
-
-
Rial, E.1
Aguirregoitia, E.2
Jiménez-Jiménez, J.3
Ledesma, A.4
-
37
-
-
4644295401
-
Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids
-
Shabalina IG, Jacobsson A, Cannon B, Nedergaard J. Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids. J Biol Chem 2004; 279: 38236-48.
-
(2004)
J Biol Chem
, vol.279
, pp. 38236-38248
-
-
Shabalina, I.G.1
Jacobsson, A.2
Cannon, B.3
Nedergaard, J.4
-
38
-
-
0014500234
-
Brown fat and thermogenesis
-
Smith RE, Horwitz BA. Brown fat and thermogenesis. Physiol Rev 1969; 49: 330-425.
-
(1969)
Physiol Rev
, vol.49
, pp. 330-425
-
-
Smith, R.E.1
Horwitz, B.A.2
-
39
-
-
0344678342
-
Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2
-
Rial E, González-Barroso MM, Fleury C, et al. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2. EMBO J 1999; 18: 5827-33.
-
(1999)
EMBO J
, vol.18
, pp. 5827-5833
-
-
Rial, E.1
González-Barroso, M.M.2
Fleury, C.3
-
40
-
-
0034710829
-
Chimeric proteins between UCP1 and UCP3: The middle third of UCP1 is necessary and sufficient for activation by fatty acids
-
Hagen T, Lowell BB. Chimeric proteins between UCP1 and UCP3: the middle third of UCP1 is necessary and sufficient for activation by fatty acids. Biochem Biophys Res Commun 2000; 276: 642-8.
-
(2000)
Biochem Biophys Res Commun
, vol.276
, pp. 642-648
-
-
Hagen, T.1
Lowell, B.B.2
-
41
-
-
0035059393
-
Structure-function relationships in UCP1, UCP2 and chimeras: EPR analysis and retinoic acid activation of UCP2
-
Chomiki N, Voss JC, Warden CH. Structure-function relationships in UCP1, UCP2 and chimeras: EPR analysis and retinoic acid activation of UCP2. Eur J Biochem 2001; 268: 903-13.
-
(2001)
Eur J Biochem
, vol.268
, pp. 903-913
-
-
Chomiki, N.1
Voss, J.C.2
Warden, C.H.3
-
42
-
-
33748954833
-
Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1
-
Jiménez-Jiménez J, Ledesma A, Zaragoza P, González-Barroso MM, Rial E. Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1. Biochim Biophys Acta 2006; 1757: 1292-6.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 1292-1296
-
-
Jiménez-Jiménez, J.1
Ledesma, A.2
Zaragoza, P.3
González-Barroso, M.M.4
Rial, E.5
-
43
-
-
0032582799
-
The mechanism of proton transport mediated by mitochondrial uncoupling proteins
-
Garlid KD, Jaburek M, Jezek P. The mechanism of proton transport mediated by mitochondrial uncoupling proteins. FEBS Lett 1998; 438: 10-4.
-
(1998)
FEBS Lett
, vol.438
, pp. 10-14
-
-
Garlid, K.D.1
Jaburek, M.2
Jezek, P.3
-
44
-
-
0035282920
-
Uncoupling proteins: The issues from a biochemist point of view
-
Klingenberg M, Echtay KS. Uncoupling proteins: the issues from a biochemist point of view. Biochim Biophys Acta 2001; 1504: 128-43.
-
(2001)
Biochim Biophys Acta
, vol.1504
, pp. 128-143
-
-
Klingenberg, M.1
Echtay, K.S.2
-
45
-
-
0037992176
-
Inactive fatty acids are unable to flip-flop across the lipid bilayer
-
Jezek P, Modriansky M, Garlid KD. Inactive fatty acids are unable to flip-flop across the lipid bilayer. FEBS Lett 1997; 408: 161-5.
-
(1997)
FEBS Lett
, vol.408
, pp. 161-165
-
-
Jezek, P.1
Modriansky, M.2
Garlid, K.D.3
-
46
-
-
3543015012
-
Activation by retinoids of the uncoupling protein UCP1
-
Tomás P, Jiménez-Jiménez J, Zaragoza P, Vuligonda V, Chandraratna RA, Rial E. Activation by retinoids of the uncoupling protein UCP1. Biochim Biophys Acta 2004; 1658: 157-64.
-
(2004)
Biochim Biophys Acta
, vol.1658
, pp. 157-164
-
-
Tomás, P.1
Jiménez-Jiménez, J.2
Zaragoza, P.3
Vuligonda, V.4
Chandraratna, R.A.5
Rial, E.6
-
47
-
-
33748660871
-
Undecanesulfonate does not allosterically activate H+ uniport mediated by uncoupling protein-1 in brown adipose tissue mitochondria
-
Jezek P, Spacek T, Garlid K, Jaburek M. Undecanesulfonate does not allosterically activate H+ uniport mediated by uncoupling protein-1 in brown adipose tissue mitochondria. Int J Biochem Cell Biol 2006; 38: 1965-74.
-
(2006)
Int J Biochem Cell Biol
, vol.38
, pp. 1965-1974
-
-
Jezek, P.1
Spacek, T.2
Garlid, K.3
Jaburek, M.4
-
48
-
-
0032488633
-
H+ transport by uncoupling protein (UCP-1) is dependent on a histidine pair, absent in UCP-2 and UCP-3
-
Bienengraeber M, Echtay KS, Klingenberg M. H+ transport by uncoupling protein (UCP-1) is dependent on a histidine pair, absent in UCP-2 and UCP-3. Biochemistry 1998; 37: 3-8.
-
(1998)
Biochemistry
, vol.37
, pp. 3-8
-
-
Bienengraeber, M.1
Echtay, K.S.2
Klingenberg, M.3
-
49
-
-
33744796595
-
Evolutionary distinct residues in UCP1 confer its characteristic basal proton conductance
-
Jiménez-Jiménez J, Zardoya R, Ledesma A, et al. Evolutionary distinct residues in UCP1 confer its characteristic basal proton conductance. J Mol Biol 2006; 359: 1010-22.
-
(2006)
J Mol Biol
, vol.359
, pp. 1010-1022
-
-
Jiménez-Jiménez, J.1
Zardoya, R.2
Ledesma, A.3
-
50
-
-
37549064399
-
Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals
-
Saito S, Saito CT, Shingai R. Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals. Gene 2008; 408: 37-44.
-
(2008)
Gene
, vol.408
, pp. 37-44
-
-
Saito, S.1
Saito, C.T.2
Shingai, R.3
-
51
-
-
0035214180
-
Uncoupling protein 2 in the brain: Distribution and function
-
Richard D, Clavel S, Huang Q, Sanchis D, Ricquier D. Uncoupling protein 2 in the brain: distribution and function. Biochem Soc Trans 2001; 29: 812-7.
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 812-817
-
-
Richard, D.1
Clavel, S.2
Huang, Q.3
Sanchis, D.4
Ricquier, D.5
-
52
-
-
0033667705
-
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
-
Arsenijevic D, Onuma H, Pecqueur C, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000; 26: 435-439.
-
(2000)
Nat Genet
, vol.26
, pp. 435-439
-
-
Arsenijevic, D.1
Onuma, H.2
Pecqueur, C.3
-
53
-
-
1242336976
-
Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice
-
Horimoto M, Fulop P, Derdak Z, Wands JR, Baffy G. Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Hepatology 2004; 39: 386-92.
-
(2004)
Hepatology
, vol.39
, pp. 386-392
-
-
Horimoto, M.1
Fulop, P.2
Derdak, Z.3
Wands, J.R.4
Baffy, G.5
-
54
-
-
43749104043
-
Mitochondrial uncoupling protein-2 mediates steatotic liver injury following ischemia/reperfusion
-
Evans ZP, Ellett JD, Schmidt MG, Schnellmann RG, Chavin KD. Mitochondrial uncoupling protein-2 mediates steatotic liver injury following ischemia/reperfusion. J Biol Chem 2008; 283: 8573-9.
-
(2008)
J Biol Chem
, vol.283
, pp. 8573-8579
-
-
Evans, Z.P.1
Ellett, J.D.2
Schmidt, M.G.3
Schnellmann, R.G.4
Chavin, K.D.5
-
55
-
-
0037469183
-
Protective role of uncoupling protein 2 in atherosclerosis
-
Blanc J, Alves-Guerra MC, Esposito B, et al. Protective role of uncoupling protein 2 in atherosclerosis. Circulation 2003; 107: 388-90.
-
(2003)
Circulation
, vol.107
, pp. 388-390
-
-
Blanc, J.1
Alves-Guerra, M.C.2
Esposito, B.3
-
56
-
-
0037716303
-
Mitochondrial uncoupling protein 2 in the central nervous system: Neuromodulator and neuroprotector
-
Horvath TL, Diano S, Barnstable C. Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochem Pharmacol 2003; 65: 1917-21.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1917-1921
-
-
Horvath, T.L.1
Diano, S.2
Barnstable, C.3
-
57
-
-
24144475250
-
Mitochondrial uncoupling proteins in the central nervous system
-
Kim-Han JS, Dugan LL. Mitochondrial uncoupling proteins in the central nervous system. Antioxid Redox Signal 2005; 7: 1173-81.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 1173-1181
-
-
Kim-Han, J.S.1
Dugan, L.L.2
-
58
-
-
27644448810
-
Mitochondrial uncoupling proteins in the CNS: In support of function and survival
-
Andrews ZB, Diano S, Horvath TL. Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat Rev Neurosci 2005; 6: 829-40.
-
(2005)
Nat Rev Neurosci
, vol.6
, pp. 829-840
-
-
Andrews, Z.B.1
Diano, S.2
Horvath, T.L.3
-
59
-
-
0036793525
-
Characterization of a novel metabolic strategy used by drug-resistant tumor cells
-
Harper ME, Antoniou A, Villalobos-Menuey E, et al. Characterization of a novel metabolic strategy used by drug-resistant tumor cells. FASEB J 2002; 16: 1550-7.
-
(2002)
FASEB J
, vol.16
, pp. 1550-1557
-
-
Harper, M.E.1
Antoniou, A.2
Villalobos-Menuey, E.3
-
60
-
-
42349088894
-
The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells
-
Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, Baffy G. The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res 2008; 68: 2813-9.
-
(2008)
Cancer Res
, vol.68
, pp. 2813-2819
-
-
Derdak, Z.1
Mark, N.M.2
Beldi, G.3
Robson, S.C.4
Wands, J.R.5
Baffy, G.6
-
61
-
-
0030987368
-
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
-
Zhou YT, Shimabukuro M, Koyama K, et al. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci USA 1997; 94: 6386-90.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 6386-6390
-
-
Zhou, Y.T.1
Shimabukuro, M.2
Koyama, K.3
-
62
-
-
0033802857
-
Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes
-
Ceddia RB, William WN Jr, Lima FB, Flandin P, Curi R, Giacobino JP. Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes. Eur J Biochem 2000; 267: 5952-8.
-
(2000)
Eur J Biochem
, vol.267
, pp. 5952-5958
-
-
Ceddia, R.B.1
William Jr, W.N.2
Lima, F.B.3
Flandin, P.4
Curi, R.5
Giacobino, J.P.6
-
63
-
-
55049101811
-
Metformin induces oxidative stress in white adipocytes and raises UCP2 levels
-
Anedda A, Rial E, Gonzalez-Barroso MD. Metformin induces oxidative stress in white adipocytes and raises UCP2 levels. J Endocrinol 2008; 199: 33-40.
-
(2008)
J Endocrinol
, vol.199
, pp. 33-40
-
-
Anedda, A.1
Rial, E.2
Gonzalez-Barroso, M.D.3
-
64
-
-
0032991716
-
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
-
Chan CB, MacDonald PE, Saleh MC, Johns DC, Marban E, Wheeler MB. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 1999; 48: 1482-6.
-
(1999)
Diabetes
, vol.48
, pp. 1482-1486
-
-
Chan, C.B.1
MacDonald, P.E.2
Saleh, M.C.3
Johns, D.C.4
Marban, E.5
Wheeler, M.B.6
-
65
-
-
0034990987
-
Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
-
Chan CB, De Leo D, Joseph JW, et al. Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 2001; 50: 1302-10.
-
(2001)
Diabetes
, vol.50
, pp. 1302-1310
-
-
Chan, C.B.1
De Leo, D.2
Joseph, J.W.3
-
66
-
-
0035117975
-
Effects of adenoviral overexpression of uncoupling protein-2 and -3 on mitochondrial respiration in insulinoma cells
-
Hong Y, Fink BD, Dillon JS, Sivitz WI. Effects of adenoviral overexpression of uncoupling protein-2 and -3 on mitochondrial respiration in insulinoma cells. Endocrinol 2001; 142: 249-56.
-
(2001)
Endocrinol
, vol.142
, pp. 249-256
-
-
Hong, Y.1
Fink, B.D.2
Dillon, J.S.3
Sivitz, W.I.4
-
67
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, a cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret P, et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, a cell dysfunction, and type 2 diabetes. Cell 2001; 105: 745-55.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
-
68
-
-
33744548069
-
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced b cell dysfunction in isolated pancreatic islets
-
Zhang CY, Parton LE, Ye CP, et al. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced b cell dysfunction in isolated pancreatic islets. Cell Metab 2006; 3: 417-27.
-
(2006)
Cell Metab
, vol.3
, pp. 417-427
-
-
Zhang, C.Y.1
Parton, L.E.2
Ye, C.P.3
-
69
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
-
Bordone L, Motta MC, Picard F, et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 2006; 4: 210-20.
-
(2006)
PLoS Biol
, vol.4
, pp. 210-220
-
-
Bordone, L.1
Motta, M.C.2
Picard, F.3
-
70
-
-
38149130672
-
Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion
-
Affourtit C, Brand MD. Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem J 2008; 409: 199-204.
-
(2008)
Biochem J
, vol.409
, pp. 199-204
-
-
Affourtit, C.1
Brand, M.D.2
-
71
-
-
33746920386
-
Uncoupling proteins: Role in insulin resistance and insulin insufficiency
-
Chan CB, Harper ME. Uncoupling proteins: role in insulin resistance and insulin insufficiency. Curr Diabetes Rev 2006; 2: 271-83.
-
(2006)
Curr Diabetes Rev
, vol.2
, pp. 271-283
-
-
Chan, C.B.1
Harper, M.E.2
-
73
-
-
46349101669
-
On the role of uncoupling protein-2 in pancreatic beta cells
-
Affourtit C, Brand MD. On the role of uncoupling protein-2 in pancreatic beta cells. Biochim Biophys Acta 2008; 1777: 973-9.
-
(2008)
Biochim Biophys Acta
, vol.1777
, pp. 973-979
-
-
Affourtit, C.1
Brand, M.D.2
-
74
-
-
0346340042
-
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction
-
Krauss S, Zhang CY, Scorrano L, et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 2003; 112: 1831-42.
-
(2003)
J Clin Invest
, vol.112
, pp. 1831-1842
-
-
Krauss, S.1
Zhang, C.Y.2
Scorrano, L.3
-
75
-
-
33845949078
-
Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species
-
Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, et al. Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species. Diabetologia 2007; 50: 84-93.
-
(2007)
Diabetologia
, vol.50
, pp. 84-93
-
-
Produit-Zengaffinen, N.1
Davis-Lameloise, N.2
Perreten, H.3
-
76
-
-
18244379331
-
Superoxide activates mitochondrial uncoupling proteins
-
Echtay KS, Roussel D, St-Pierre J, et al. Superoxide activates mitochondrial uncoupling proteins. Nature 2002; 415: 96-99.
-
(2002)
Nature
, vol.415
, pp. 96-99
-
-
Echtay, K.S.1
Roussel, D.2
St-Pierre, J.3
-
77
-
-
0037135559
-
No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria
-
Couplan E, Gonzalez-Barroso MM, Alves-Guerra MC, Ricquier D, Goubern M, Bouillaud F. No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J Biol Chem 2002; 277: 26268-75.
-
(2002)
J Biol Chem
, vol.277
, pp. 26268-26275
-
-
Couplan, E.1
Gonzalez-Barroso, M.M.2
Alves-Guerra, M.C.3
Ricquier, D.4
Goubern, M.5
Bouillaud, F.6
-
78
-
-
0037411282
-
4-Hydroxy-2-nonenal: A product and mediator of oxidative stress
-
Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 2003; 42: 318-43.
-
(2003)
Prog Lipid Res
, vol.42
, pp. 318-343
-
-
Uchida, K.1
-
79
-
-
0041465009
-
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
-
Echtay KS, Esteves TC, Pakay JL, et al. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J 2003; 22: 4103-10.
-
(2003)
EMBO J
, vol.22
, pp. 4103-4110
-
-
Echtay, K.S.1
Esteves, T.C.2
Pakay, J.L.3
-
80
-
-
33748969187
-
Participation of ATP/ADP antiporter in oleate-and oleate hydroperoxide-induced uncoupling suppressed by GDP and carboxyatractylate
-
Khailova LS, Prikhodko EA, Dedukhova VI, Mokhova EN, Popov VN, Skulachev VP. Participation of ATP/ADP antiporter in oleate-and oleate hydroperoxide-induced uncoupling suppressed by GDP and carboxyatractylate. Biochim Biophys Acta 2006; 1757: 1324-9.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 1324-1329
-
-
Khailova, L.S.1
Prikhodko, E.A.2
Dedukhova, V.I.3
Mokhova, E.N.4
Popov, V.N.5
Skulachev, V.P.6
-
81
-
-
0014421614
-
Adenine nucleotide translocation of mitochondria. 1. Specificity and control
-
Pfaff E, Klingenberg M. Adenine nucleotide translocation of mitochondria. 1. Specificity and control. Eur J Biochem 1968; 6: 66-79.
-
(1968)
Eur J Biochem
, vol.6
, pp. 66-79
-
-
Pfaff, E.1
Klingenberg, M.2
-
82
-
-
52049113898
-
The ADP and ATP transport in mitochondria and its carrier
-
Klingenberg M. The ADP and ATP transport in mitochondria and its carrier. Biochim Biophys Acta 2008; 1778: 1978-2021.
-
(2008)
Biochim Biophys Acta
, vol.1778
, pp. 1978-2021
-
-
Klingenberg, M.1
-
83
-
-
33744915836
-
UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent
-
Shabalina IG, Petrovic N, Kramarova TV, Hoeks J, Cannon B, Nedergaard J. UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent. J Biol Chem 2006; 281: 13882-93.
-
(2006)
J Biol Chem
, vol.281
, pp. 13882-13893
-
-
Shabalina, I.G.1
Petrovic, N.2
Kramarova, T.V.3
Hoeks, J.4
Cannon, B.5
Nedergaard, J.6
-
84
-
-
0042415622
-
A function for novel uncoupling proteins: Antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
-
Goglia F, Skulachev VP. A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet. FASEB J 2003; 17: 1585-91.
-
(2003)
FASEB J
, vol.17
, pp. 1585-1591
-
-
Goglia, F.1
Skulachev, V.P.2
-
85
-
-
11144234168
-
Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2
-
Jaburek M, Miyamoto S, Di Mascio P, Garlid KD, Jezek P. Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2. J Biol Chem 2004; 279: 53097-102.
-
(2004)
J Biol Chem
, vol.279
, pp. 53097-53102
-
-
Jaburek, M.1
Miyamoto, S.2
Di Mascio, P.3
Garlid, K.D.4
Jezek, P.5
-
86
-
-
0037039366
-
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
-
Krauss S, Zhang CY, Lowell BB. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci USA 2002; 99: 118-22.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 118-122
-
-
Krauss, S.1
Zhang, C.Y.2
Lowell, B.B.3
-
87
-
-
0031560941
-
UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
-
Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 1997; 235: 79-82.
-
(1997)
Biochem Biophys Res Commun
, vol.235
, pp. 79-82
-
-
Vidal-Puig, A.1
Solanes, G.2
Grujic, D.3
Flier, J.S.4
Lowell, B.B.5
-
88
-
-
0033030622
-
Molecular and genetic aspects of the UCPs: View from the chair
-
Stock MJ. Molecular and genetic aspects of the UCPs: view from the chair. Int J Obes Relat Metab Disord 1999; 23: S51-2.
-
(1999)
Int J Obes Relat Metab Disord
, vol.23
-
-
Stock, M.J.1
-
89
-
-
0033041341
-
Effects of dietary deprivation, obesity and exercise on UCP3 mRNA levels
-
Giacobino JP. Effects of dietary deprivation, obesity and exercise on UCP3 mRNA levels. Int J Obes Relat Metab Disord 1999; 23: S60-3.
-
(1999)
Int J Obes Relat Metab Disord
, vol.23
-
-
Giacobino, J.P.1
-
90
-
-
0035195527
-
Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice
-
Bézaire V, Hofmann W, Kramer JK, Kozak LP, Harper ME. Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. Am J Physiol Endocrinol Metab 2001; 281: E975-82.
-
(2001)
Am J Physiol Endocrinol Metab
, vol.281
-
-
Bézaire, V.1
Hofmann, W.2
Kramer, J.K.3
Kozak, L.P.4
Harper, M.E.5
-
91
-
-
2942532803
-
Links between fatty acids and expression of UCP2 and UCP3 mRNAs
-
Thompson MP, Kim D. Links between fatty acids and expression of UCP2 and UCP3 mRNAs. FEBS Lett 2004; 568: 4-9.
-
(2004)
FEBS Lett
, vol.568
, pp. 4-9
-
-
Thompson, M.P.1
Kim, D.2
-
92
-
-
0035339643
-
Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models
-
Kratky D, Strauss JG, Zechner R. Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models. Biochem J 2001; 355: 647-52.
-
(2001)
Biochem J
, vol.355
, pp. 647-652
-
-
Kratky, D.1
Strauss, J.G.2
Zechner, R.3
-
93
-
-
0036777736
-
Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter
-
Schrauwen P, Hinderling V, Hesselink MK, et al. Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter. FASEB J 2002; 16: 1688-90.
-
(2002)
FASEB J
, vol.16
, pp. 1688-1690
-
-
Schrauwen, P.1
Hinderling, V.2
Hesselink, M.K.3
-
94
-
-
42749100308
-
PPARs in the control of uncoupling proteins gene expression
-
Villarroya F, Iglesias R, Giralt M. PPARs in the control of uncoupling proteins gene expression. PPAR Res 2007; 2007: 74364.
-
(2007)
PPAR Res 2007
, pp. 74364
-
-
Villarroya, F.1
Iglesias, R.2
Giralt, M.3
-
95
-
-
28644442428
-
SOD2 overexpression: Enhanced mitochondrial tolerance but absence of effect on UCP activity
-
Silva JP, Shabalina IG, Dufour E, et al. SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity. EMBO J 2005; 24: 4061-70.
-
(2005)
EMBO J
, vol.24
, pp. 4061-4070
-
-
Silva, J.P.1
Shabalina, I.G.2
Dufour, E.3
-
96
-
-
2242425423
-
Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
-
Brand MD, Pamplona R, Portero-Otín M, et al. Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. Biochem J 2002; 368: 597-603.
-
(2002)
Biochem J
, vol.368
, pp. 597-603
-
-
Brand, M.D.1
Pamplona, R.2
Portero-Otín, M.3
-
97
-
-
23644434842
-
Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells
-
MacLellan JD, Gerrits MF, Gowing A, Smith PJ, Wheeler MB, Harper ME. Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes 2005; 54: 2343-50.
-
(2005)
Diabetes
, vol.54
, pp. 2343-2350
-
-
MacLellan, J.D.1
Gerrits, M.F.2
Gowing, A.3
Smith, P.J.4
Wheeler, M.B.5
Harper, M.E.6
-
98
-
-
30044432203
-
Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose
-
Mozo J, Ferry G, Studeny A, et al. Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose. Biochem J 2006; 393: 431-9.
-
(2006)
Biochem J
, vol.393
, pp. 431-439
-
-
Mozo, J.1
Ferry, G.2
Studeny, A.3
-
99
-
-
0035162543
-
An alternative function for human uncoupling protein 3: Protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix
-
Schrauwen P, Saris WH, Hesselink MK. An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix. FASEB J 2001; 15: 2497-502.
-
(2001)
FASEB J
, vol.15
, pp. 2497-2502
-
-
Schrauwen, P.1
Saris, W.H.2
Hesselink, M.K.3
-
100
-
-
0035133171
-
Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
-
Himms-Hagen J, Harper ME. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med 2001; 226: 78-84.
-
(2001)
Exp Biol Med
, vol.226
, pp. 78-84
-
-
Himms-Hagen, J.1
Harper, M.E.2
-
101
-
-
0036138306
-
The role acyl-CoA thioesterases play in mediating intracellular lipid metabolism
-
Hunt MC, Alexson SE. The role acyl-CoA thioesterases play in mediating intracellular lipid metabolism. Prog Lipid Res 2002; 41: 99-130.
-
(2002)
Prog Lipid Res
, vol.41
, pp. 99-130
-
-
Hunt, M.C.1
Alexson, S.E.2
-
102
-
-
54449089267
-
Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export
-
Seifert EL, Bézaire V, Estey C, Harper ME. Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export. J Biol Chem 2008; 283: 25124-31.
-
(2008)
J Biol Chem
, vol.283
, pp. 25124-25131
-
-
Seifert, E.L.1
Bézaire, V.2
Estey, C.3
Harper, M.E.4
|