메뉴 건너뛰기




Volumn 23, Issue 11, 2009, Pages 1383-1388

Immunological success is predicted by enfuvirtide but not interleukin-2 therapy in immunodepressed patients

Author keywords

Enfuvirtide; HIV; Interleukin 2; Randomized trial; Treatment failure

Indexed keywords

ENFUVIRTIDE; INTERLEUKIN 2; RITONAVIR PLUS TIPRANAVIR; VIRUS RNA;

EID: 68449098785     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32832cdc26     Document Type: Article
Times cited : (9)

References (27)
  • 1
    • 33845506881 scopus 로고    scopus 로고
    • Cytokine-based modulation of immune function in HIV infection
    • Lévy Y. Cytokine-based modulation of immune function in HIV infection. Curr Opin HIV AIDS 2006; 1:69-73.
    • (2006) Curr Opin HIV AIDS , vol.1 , pp. 69-73
    • Lévy, Y.1
  • 2
    • 0037964336 scopus 로고    scopus 로고
    • IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients wit severe CD4 lympho-penia
    • Carcelain G, Saint-Mézard P, Altes HK, Tubiana R, Grenot P, Rabian C, et al. IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients wit severe CD4 lympho-penia. AIDS 2003; 17:841-850.
    • (2003) AIDS , vol.17 , pp. 841-850
    • Carcelain, G.1    Saint-Mézard, P.2    Altes, H.K.3    Tubiana, R.4    Grenot, P.5    Rabian, C.6
  • 4
    • 23644439060 scopus 로고    scopus 로고
    • Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients
    • Kovacs J, Lempicki RA, Sidorov IA, Adelsberger JW, Sereti I, Sachau W, et al. Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients. J Clin Invest 2005; 115:2139-2148.
    • (2005) J Clin Invest , vol.115 , pp. 2139-2148
    • Kovacs, J.1    Lempicki, R.A.2    Sidorov, I.A.3    Adelsberger, J.W.4    Sereti, I.5    Sachau, W.6
  • 5
    • 0033526641 scopus 로고    scopus 로고
    • Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: A randomized trial
    • Lévy Y, Capitant C, Houhou S, Carrière I, Viard JP, Goujard C, et al. Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: a randomized trial. Lancet 1999; 353:1923-1929.
    • (1999) Lancet , vol.353 , pp. 1923-1929
    • Lévy, Y.1    Capitant, C.2    Houhou, S.3    Carrière, I.4    Viard, J.P.5    Goujard, C.6
  • 6
    • 0035822985 scopus 로고    scopus 로고
    • Immunological and virological effects of long-term IL-2 therapy in HIV-infected patients
    • Gougeon ML, Rouzioux C, Liberman I, Burgard M, Taoufik Y, Viard JP, et al. Immunological and virological effects of long-term IL-2 therapy in HIV-infected patients. AIDS 2001; 15:1729-1731.
    • (2001) AIDS , vol.15 , pp. 1729-1731
    • Gougeon, M.L.1    Rouzioux, C.2    Liberman, I.3    Burgard, M.4    Taoufik, Y.5    Viard, J.P.6
  • 7
    • 0037436193 scopus 로고    scopus 로고
    • Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: A randomised controlled trial
    • Lévy Y, Durier C, Krzysiek R, Rabian C, Capitant C, Lascaux AS, et al. Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomised controlled trial. AIDS 2003; 17:343-352.
    • (2003) AIDS , vol.17 , pp. 343-352
    • Lévy, Y.1    Durier, C.2    Krzysiek, R.3    Rabian, C.4    Capitant, C.5    Lascaux, A.S.6
  • 8
    • 34548260503 scopus 로고    scopus 로고
    • Long-terme effects of intermittent interleukin-2 therapy in chronic HIV-infected patients (ANRS 048+-079 trials)
    • Durier C, Capitant C, Lascaux AS, Goujard C, Oksenhendler E, Poizot-Martin I, et al. Long-terme effects of intermittent interleukin-2 therapy in chronic HIV-infected patients (ANRS 048+-079 trials). AIDS 2007; 21:1887-1897.
    • (2007) AIDS , vol.21 , pp. 1887-1897
    • Durier, C.1    Capitant, C.2    Lascaux, A.S.3    Goujard, C.4    Oksenhendler, E.5    Poizot-Martin, I.6
  • 9
    • 34047166933 scopus 로고    scopus 로고
    • The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection
    • Mitsuyasu R, Gelman R, Cherng DW, Landay A, Fahay J, Reich-man R, et al. The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection. Arch Intern Med 2007; 167:597-605.
    • (2007) Arch Intern Med , vol.167 , pp. 597-605
    • Mitsuyasu, R.1    Gelman, R.2    Cherng, D.W.3    Landay, A.4    Fahay, J.5    Reich-man, R.6
  • 10
    • 0033017140 scopus 로고    scopus 로고
    • Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency virus type 1 in persons with <250/microL CD4 T cells and undetectable plasma virus load
    • Arnó A, Ruiz L, Juan M, Jou A, Balagué M, Zayat MK, et al. Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human immunodeficiency virus type 1 in persons with <250/microL CD4 T cells and undetectable plasma virus load. J Infect Dis 1999; 180:56-60.
    • (1999) J Infect Dis , vol.180 , pp. 56-60
    • Arnó, A.1    Ruiz, L.2    Juan, M.3    Jou, A.4    Balagué, M.5    Zayat, M.K.6
  • 11
    • 0035282639 scopus 로고    scopus 로고
    • Rapid effect of interleukin-2 therapy in human immunodeficiency virus-infected persons whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment
    • David D, Naït-lghil L, Dupont B, Maral J, Gachot B, Thèze J. Rapid effect of interleukin-2 therapy in human immunodeficiency virus-infected persons whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment. J Infect Dis 2001; 183:730-735.
    • (2001) J Infect Dis , vol.183 , pp. 730-735
    • David, D.1    Naït-lghil, L.2    Dupont, B.3    Maral, J.4    Gachot, B.5    Thèze, J.6
  • 12
    • 0036720644 scopus 로고    scopus 로고
    • Low-dose prolonged intermittent interleukin-2 adjuvant therapy: Results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairment
    • Marchetti G, Meroni L, Varchetta S, Terzieva V, Bandera A, Manganaro D, et al. Low-dose prolonged intermittent interleukin-2 adjuvant therapy: results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairment. J Infect Dis 2002; 186: 606-616.
    • (2002) J Infect Dis , vol.186 , pp. 606-616
    • Marchetti, G.1    Meroni, L.2    Varchetta, S.3    Terzieva, V.4    Bandera, A.5    Manganaro, D.6
  • 13
    • 0037131199 scopus 로고    scopus 로고
    • Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy: The ILSTIM study-ANRS 082
    • Katlama C, Carcelain G, Duvivier C, Chouquet C, Tubiana R, De Sa M, et al. Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy: the ILSTIM study-ANRS 082. AIDS 2002; 16:2027-2034.
    • (2002) AIDS , vol.16 , pp. 2027-2034
    • Katlama, C.1    Carcelain, G.2    Duvivier, C.3    Chouquet, C.4    Tubiana, R.5    De Sa, M.6
  • 14
    • 0642347180 scopus 로고    scopus 로고
    • Nadir CD4+ T cell count predicts response to subcutaneous recombinant interleukin-2
    • Markowitz N, Bebchuk JD, Abrams Dl. Nadir CD4+ T cell count predicts response to subcutaneous recombinant interleukin-2. Clin Infect Dis 2003; 37:e115-e120.
    • (2003) Clin Infect Dis , vol.37
    • Markowitz, N.1    Bebchuk, J.D.2    Abrams, D.3
  • 15
    • 33846944430 scopus 로고    scopus 로고
    • A randomised trial of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-infected patients: The UK-Vanguard study
    • doi: 10.1371/journal.pctr.0010003
    • Youle M, Emery S, Fisher M, Nelson M, Fosdick L, Janossy G, et al. A randomised trial of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-infected patients: the UK-Vanguard study. PloS Clin Trials 2006; 1:e3; doi: 10.1371/journal.pctr.0010003.
    • (2006) PloS Clin Trials , vol.1
    • Youle, M.1    Emery, S.2    Fisher, M.3    Nelson, M.4    Fosdick, L.5    Janossy, G.6
  • 16
    • 49649127208 scopus 로고    scopus 로고
    • Long-term clinical and surrogate marker effects of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-infected patients
    • Herzman C, Cuthbertson Z, Fosdick L, Fisher, Nelson M, Perry N, et al. Long-term clinical and surrogate marker effects of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-infected patients. J Antimicrob Chemother 2008; 62:583-586.
    • (2008) J Antimicrob Chemother , vol.62 , pp. 583-586
    • Herzman, C.1    Cuthbertson, Z.2    Fosdick, L.3    Fisher4    Nelson, M.5    Perry, N.6
  • 17
    • 68449090169 scopus 로고    scopus 로고
    • Molina JM, Lévy Y, Fournier I, Boulet T, Bentata M, Beck-Wirth G, et al. Predictors of slow disease progression in ART-naïve HIV-1-infected patients treated with IL-2:3 year extended follow-up of the INTERSTART ANRS 119 trial [abstract #702]. 15th Conference on Retroviruses and Opportunistic Infections; 3-6 February 2008; Boston, Massachusetts; 2008.
    • Molina JM, Lévy Y, Fournier I, Boulet T, Bentata M, Beck-Wirth G, et al. Predictors of slow disease progression in ART-naïve HIV-1-infected patients treated with IL-2:3 year extended follow-up of the INTERSTART ANRS 119 trial [abstract #702]. 15th Conference on Retroviruses and Opportunistic Infections; 3-6 February 2008; Boston, Massachusetts; 2008.
  • 18
    • 34548058080 scopus 로고    scopus 로고
    • CD4+ T cell responses to interleukin-2 administration in HIV-infected patients are directly related to the baseline level of immune activation
    • Sereti I, Sklar P, Ramchandani S, Read SW, Aggarwal V, Imamichi H, et al. CD4+ T cell responses to interleukin-2 administration in HIV-infected patients are directly related to the baseline level of immune activation. J Infect Dis 2007; 196: 677-683.
    • (2007) J Infect Dis , vol.196 , pp. 677-683
    • Sereti, I.1    Sklar, P.2    Ramchandani, S.3    Read, S.W.4    Aggarwal, V.5    Imamichi, H.6
  • 19
    • 33847773493 scopus 로고    scopus 로고
    • Predictors of CD4 count change over 8 months of follow up in HIV-1-infected patients with a CD4 count >300 cells/μI who were assigned to 7.5 MIU interleukin-2
    • ESPRIT Research Group
    • ESPRIT Research Group. Predictors of CD4 count change over 8 months of follow up in HIV-1-infected patients with a CD4 count >300 cells/μI who were assigned to 7.5 MIU interleukin-2. HIV Med 2007; 8:112-23.
    • (2007) HIV Med , vol.8 , pp. 112-123
  • 20
  • 22
    • 60749083560 scopus 로고    scopus 로고
    • Interleukin-2 therapy does not increase the risk of Hodgkin or non-Hodgkin lymphoma in HIV-infected patient, results from FHDH ANRS CO4
    • Fontas E, Kousignian I, Pradier C, Duvivier C, Poizot-Martin I, Durier C, et al. Interleukin-2 therapy does not increase the risk of Hodgkin or non-Hodgkin lymphoma in HIV-infected patient, results from FHDH ANRS CO4. J Acquir Immune Defic Syndr 2009; 50:206-214.
    • (2009) J Acquir Immune Defic Syndr , vol.50 , pp. 206-214
    • Fontas, E.1    Kousignian, I.2    Pradier, C.3    Duvivier, C.4    Poizot-Martin, I.5    Durier, C.6
  • 23
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
    • Lalezari JP, Henry K, O'Hearn M, Montaner JS, Piliero PJ, Trottier B, et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. N Engl J Med 2003; 348:2175-2185.
    • (2003) N Engl J Med , vol.348 , pp. 2175-2185
    • Lalezari, J.P.1    Henry, K.2    O'Hearn, M.3    Montaner, J.S.4    Piliero, P.J.5    Trottier, B.6
  • 24
    • 0037849954 scopus 로고    scopus 로고
    • Efficacy of Enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia
    • Lazzarin A, Clotet B, Cooper D, Reynes J, Arastéh K, Nelson M, et al. Efficacy of Enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. N Engl J Med 2003; 348:2186-2195.
    • (2003) N Engl J Med , vol.348 , pp. 2186-2195
    • Lazzarin, A.1    Clotet, B.2    Cooper, D.3    Reynes, J.4    Arastéh, K.5    Nelson, M.6
  • 25
    • 43949084344 scopus 로고    scopus 로고
    • Specific enfuvirtide-associated mutational pathways in HIV-1 gp 41 are significantly correlated with an increase in CD4+ cell count, despite virological failure
    • Svicher V, Aquaro S, D'Arrigo R, Artese A, Dimonte S, Alcaro S, et al. Specific enfuvirtide-associated mutational pathways in HIV-1 gp 41 are significantly correlated with an increase in CD4+ cell count, despite virological failure. J Infect Dis 2008; 197:1408-1418.
    • (2008) J Infect Dis , vol.197 , pp. 1408-1418
    • Svicher, V.1    Aquaro, S.2    D'Arrigo, R.3    Artese, A.4    Dimonte, S.5    Alcaro, S.6
  • 27
    • 4143148495 scopus 로고    scopus 로고
    • Immunological and virological study of enfuvirtide-treated HIV-positive patients
    • Barretina J, Blanco J, Bonjoch A, Llano A, Clotet B, Esté JA. Immunological and virological study of enfuvirtide-treated HIV-positive patients. AIDS 2004; 18:1673-1682.
    • (2004) AIDS , vol.18 , pp. 1673-1682
    • Barretina, J.1    Blanco, J.2    Bonjoch, A.3    Llano, A.4    Clotet, B.5    Esté, J.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.