Outcome predictors in African-American deceased-donor renal allograft recipients

Clinical Transplantation

Volumn 23, Issue 4, 2009, Pages 454-461

  Brown, Kristian L ^a   El Amm, Jose M ^a   Doshi, Mona D ^a   Singh, Atul ^a   Cincotta, Elizabeth ^b   Morawski, Katherina ^a   Losanoff, Julian E ^a   West, Miguel S ^a   Gruber, Scott A ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARPER UNIVERSITY HOSPITAL   (United States)

Author keywords

African American; Deceased donor; Outcomes; Renal transplantation; Risk factors

Indexed keywords

BASILIXIMAB; COTRIMOXAZOLE; GANCICLOVIR; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY; VALGANCICLOVIR;

ACUTE GRAFT REJECTION; ADULT; AFRICAN AMERICAN; ARTICLE; CHRONIC ALLOGRAFT NEPHROPATHY; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DECEASED DONOR; DELAYED GRAFT FUNCTION; DIABETES MELLITUS; DRUG DOSE REDUCTION; ETHNICITY; FEMALE; FOCAL GLOMERULOSCLEROSIS; GASTROINTESTINAL SYMPTOM; GRAFT FAILURE; GRAFT RECIPIENT; HEPATITIS C; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; LEUKOPENIA; MAJOR CLINICAL STUDY; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; ORGAN DONOR; PATIENT COMPLIANCE; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; SURGICAL MORTALITY; SURGICAL RISK; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ADULT; AFRICAN AMERICANS; CADAVER; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLUCOCORTICOIDS; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MEDICATION ADHERENCE; MIDDLE AGED; PREDNISONE; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 68449098441     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2008.00917.x     Document Type: Article

References (33)

1. Young CJ, Gaston RS. Renal transplantation in black Americans. N Engl J Med 2000: 343: 1545.
2. Young CJ, Kew C. Health disparities in transplantation: Focus on the complexity and challenge of renal transplantation in African Americans. Med Clin North Am 2005: 89: 1003.
3. Hardinger KL, Stratta RJ, Egidi MF et al. Renal allograft outcomes in African American versus Caucasian transplant recipients in the tacrolimus era. Surgery 2001: 130: 738.
4. Foster CE III, Philosophe B, Schweitzer EJ et al. A decade of experience with renal transplantation in African-Americans. Ann Surg 2002: 236: 794.
5. Light JA, Barhyte DY, Lahman L. Kidney transplants in African Americans and non-African Americans: Equivalent outcomes with living but not deceased donors. Transplant Proc 2005: 37: 699.
6. Boardman RE, Alloway RR, Alexander JW et al. African-American renal transplant recipients benefit from early corticosteroid withdrawal under modern immunosuppression. Am J Transplant 2005: 5: 356.
7. Anil Kumar MS, Moritz MJ, Saaed MI et al. Avoidance of chronic steroid therapy in African American kidney transplant recipients monitored by surveillance biopsy: 1-year results. Am J Transplant 2005: 5: 1976.
8. Isaacs RB, Nock SL, Spencer CE et al. Racial disparities in renal transplant outcomes. Am J Kidney Dis 1999: 34: 706.
9. Meier-Kriesche HU, Ojo A, Magee JC et al. African-American renal transplant recipients experience decreased risk of death due to infection: Possible implications for immunosuppressive strategies. Transplantation 2000: 70: 375.
10. Chakkera HA, O'Hare AM, Johansen KL et al. Influence of race on kidney transplant outcomes within and outside the Department of Veterans Affairs. J Am Soc Nephrol 2005: 16: 269.
11. Eckhoff DE, Young CJ, Gaston RS et al. Racial disparities in renal allograft survival: A public health issue? J Am Coll Surg 2007: 204: 894.
12. Haririan A, Morawski K, Sillix DH et al. Induction therapy with basiliximab versus thymoglobulin in African-American kidney transplant recipients. Transplantation 2005: 79: 716.
13. Smith SR, Butterly DW. Declining influence of race on the outcome of living-donor renal transplantation. Am J Transplant 2002: 2: 282.
14. Andreoni KA, Brayman KL, Guidinger MK, Sommers CM, Sung RS. Kidney and pancreas transplantation in the United States, 1996-2005. Am J Transplant 2007: 7: 1359.
15. Brown KL, El-Amm JM, Doshi MD et al. Intermediate-term outcomes of hepatitis C+ versus hepatitis C-deceased-donor renal allograft recipients. Am J Surg 2008: 195: 298.
16. Agha IA, Rueda A, Alvarez J et al. Short course induction immunosuppression with thymoglobulin for renal transplant recipients. Transplantation 2002: 73: 473.
17. Gruber SA, West MS, Sillix DH et al. Preliminary results with early corticosteroid withdrawal in African-American renal allograft recipients. Surgery 2005: 138: 772.
18. Haririan A, Sillix DH, Morawski K et al. Short-term experience with early steroid withdrawal in African-American renal transplant recipients. Am J Transplant 2006: 6: 2396.
19. OPTN/SRTR Annual Report. Available at: http://www.ustransplant.org/ annual_reports/current, 2007.
20. Denhaerynck K, Dobbels F, Cleemput I et al. Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: A literature review. Transpl Int 2005: 18: 1121.
21. Bullington P, Pawola L, Walker R, Valenta A, Briars L, John E. Identification of medication non-adherence factors in adolescent transplant patients: The patient's viewpoint. Pediatr Transplant 2007: 11: 914.
22. Curtis JJ. Kidney transplantation: Racial or socioeconomic disparities. Am J Kidney Dis 1999: 34: 756.
23. Schweizer RT, Rovelli M, Palmeri D, Vossler E, Hull D, B artus S. Noncompliance in organ transplant recipients. Transplantation 1990: 49: 374.
24. Butkus DE, Meydrech EF, Raju SS. Racial differences in the survival of cadaveric renal allografts. Overriding effects of HLA matching and socioeconomic factors. N Engl J Med 1992: 327: 840.
25. Yarlagadda SG, Klein CL, Jani A. Long-term renal outcomes after delayed graft function. Adv Chronic Kidney Dis 2008: 15: 248.
26. Swanson SJ, Hypolite IO, Agodoa LY et al. Effect of donor factors on early graft survival in adult cadaveric renal transplantation. Am J Transplant 2002: 2: 68.
27. Chang GJ, Mahanty HD, Vincenti F et al. A calcineurin inhibitor-sparing regimen with sirolimus, mycophenolate mofetil, and anti-CD25 mAb provides effective immunosuppression in kidney transplant recipients with delayed or impaired graft function. Clin Transplant 2000: 14: 550.
28. Hong JC, Kahan BD. A calcineurin antagonist-free induction strategy for immunosuppression in cadaveric kidney transplant recipients at risk for delayed graft function. Transplantation 2001: 71: 1320.
29. Zeng X, El-Amm JM, Doshi MD et al. Intermediate-term outcomes with early steroid withdrawal in African-American renal transplant recipients undergoing surveillance biopsy. Surgery 2007: 142: 538.
30. Gruber SA. Subclinical acute rejection treated as clinical acute rejection: Same intervention, same morbidity, masked endpoint, equal reporting. Transplantation 2006: 82: 1550.
31. Doshi MD, El-Amm JM, Gruber SA. Early steroid withdrawal in African-American renal allograft recipients: Does inadequate induction lead to increased early rejection and long-term graft injury? Letter to the editor. Am J Transplant 2008: 8: 1759.
32. Flechner SM, Friend PJ, Brockmann J et al. Alemtuzumab induction and sirolimus plus mycophenolate mofetil maintenance for CNI and steroid-free kidney transplant immunosuppression. Am J Transplant 2005: 5: 3009.
33. Gelens MACJ, Christiaans MHL, van Heurn ELW, van den Berg-Loonen EPM, Peutz-Kootstra CJ, van H ooff JP. High rejection rate during calcineurin inhibitor-free and early steroid withdrawal immunosuppression in renal transplantation. Transplantation 2006: 82: 1221.