Bioline® heparin-coated ECMO with bivalirudin anticoagulation in a patient with acute heparin-induced thrombocytopenia: The immune reaction appeared to continue unabated

Perfusion

Volumn 24, Issue 2, 2009, Pages 135-137

  Pappalardo, Federico ^a   Maj, G ^a   Scandroglio, A ^a   Sampietro, F ^b   Zangrillo, A ^a   Koster, A ^c  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Bivalirudin; ECMO; Heparin induced thrombocytopenia; Outcome; Thrombosis

Indexed keywords

ANTIVITAMIN K; FONDAPARINUX; HEPARIN; HIRULOG; ANTIBODY; ANTICOAGULANT AGENT; HIRUDIN DERIVATIVE; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

ADJUVANT THERAPY; AGED; ANTIBODY DETECTION; ANTICOAGULANT THERAPY; ARTICLE; BLOOD CLOTTING TIME; BLOOD FLOW VELOCITY; CARDIOGENIC SHOCK; CASE REPORT; CONTINUOUS INFUSION; CORONARY ARTERY BYPASS GRAFT; DRUG COATING; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EXTRACORPOREAL OXYGENATION; FEMALE; HEART VENTRICLE FIBRILLATION; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; IMMUNE RESPONSE; MITRAL VALVE REGURGITATION; MITRAL VALVE REPLACEMENT; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSTHETIC VALVE THROMBOSIS; SYSTEMIC THERAPY; THROMBOCYTE COUNT; THROMBOEMBOLISM; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; ACUTE DISEASE; IMMUNOLOGY; METHODOLOGY; THROMBOCYTOPENIA;

ACUTE DISEASE; AGED; ANTIBODIES; ANTICOAGULANTS; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HEPARIN; HIRUDINS; HUMANS; MITRAL VALVE INSUFFICIENCY; PEPTIDE FRAGMENTS; PLATELET COUNT; RECOMBINANT PROTEINS; THROMBOCYTOPENIA;

EID: 68449083833     PISSN: 02676591     EISSN: None     Source Type: Journal    
DOI: 10.1177/0267659109106773     Document Type: Article

References (5)

1. Aldea, GS, Soltow, LO, Chandler, WL, et al. Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits. J Thorac Cardiovasc Surg. 2002; 123: 742-755.
2. Warkentin, TE, Greinacher, A. Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg. 2003; 76(6): 2121-2131 Review.
3. Koster, A, Huebler, S, Potapov, E, et al. Impact of heparin-induced thrombocytopenia on outcome in patients with ventricular assist device support: A single-institution experience in 358 consecutive patients. Ann Thorac Surg 2007; 83: 72-76.
4. Koster, A, Loebe, M, Sodian, R, et al. Heparin antibodies and thromboembolism in heparin-coated and noncoated ventricular assist devices. J Thorac Cardiovasc Surg 2001; 121(2): 331-335.
5. Veale, JJ, McCarthy, HM, Palmer, G, Dyke, CM. Use of bivalirudin as an anticoagulant during cardiopulmonary bypass. J Extra Corpor Technol. 2005; 37: 296-302.