Prophylactic thyroidectomy, based on direct genetic testing, in patients at risk for the multiple endocrine neoplasia type 2 syndromes

Experimental and Clinical Endocrinology and Diabetes

Volumn 106, Issue 1, 1998, Pages 29-34

  Wells Jr , S A ^a   Skinner, M A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Childhood cancer; Medullary thyroid carcinoma; Multiple endocrine neoplasia

Indexed keywords

CALCITONIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; DNA DETERMINATION; FEMALE; FOLLOW UP; GENE MUTATION; GENETIC COUNSELING; GENETIC SCREENING; HUMAN; MALE; MULTIPLE ENDOCRINE NEOPLASIA; PRIORITY JOURNAL; PROTO ONCOGENE; THYROID MEDULLARY CARCINOMA; THYROIDECTOMY;

EID: 6844261192     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211946     Document Type: Article

References (15)

1. Carlson KM, Dou S, Chi DD, Donis-Keller H: Three dinucleotide repeat polymorphisms closely linked to the RET protooncogene D10S1098, D10S1099, and D10S1100. Hum Mol Genet 3: 1207, 1994
2. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubenski IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Speigel AM, Burns AL, Marx SJ: Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276: 404-407, 1997
3. Chong GC, Beahrs OH, Sizemore GW, Woolner LH: Medullary carcinoma of the thyroid gland. Cancer 35: 695-704, 1975
4. Donis-Keller H, Dou S, Chi D, Carlson KM, Toshima K, Lairmore TC, Howe JR, Moley JF, Goodfellow P, Wells SA, Jr.: Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum Mol Gen 2: 851-856, 1993
5. Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF, van Amstel HKP, Lips CJM, Nishisho I, Takai S, Marsh DJ, Robinson BG, Frank-Raue K, Raue F, Xue F, Noll WW, Romei C, Pacini F, Fink M, Niederle B, Zenenius J, Nordensjöld M, Komminoth P, Hendy GH, Gharib H, Thibodeau SN, Lacroix A, Frilling A, Ponder BAJ, Mulligan LM: The clinical relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2: international RET mutation consortium analysis. JAMA 276: 1575-1579, 1996
6. Farndon JR, Leight GS, Dilley WG, Baylin SB, Smallridge RC, Harrison TS, Wells SA, Jr.: Familial medullary thyroid carcinoma without associated endocrinopathies: A distinct clinical entity. Br J Surg 73: 278-281, 1986
7. Melvin KEW, Tashijian AH: The syndrome of excess thyrocalcitonin produced by medullary carcinoma of the thyroid. Proc. Natl Acad Sci USA 59: 1216-1222, 1968
8. Mendelsohn G: Pathology of thyroid disease. In: Diagnosis and pathology of endocrine disease, G. Mendelsohn, Ed. Philadelphia: JB Lippincott Company, 1988, pp. 93-101
9. Milhaud G, Tubiana M, Parmentier C, Coutris G: Epithelioma de la thyroide secretant de la thyrocalcitonine. Compt Rendu Acad Sc(D) (Paris) 266: 608-610, 1968
10. Mulligan LM, Kwok JBJ, Healey CS, Elsdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papi L, Ponder MA, Telenius H, Tunnacliffe A, Ponder BAJ: Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363: 458-460, 1993
11. Norton JA, Froome LC, Farrell RE, Wells SA, Jr.: Multiple endocrine neoplasia type IIb- the most aggressive form of medullary thyroid carcinoma. Surg Clin North Am 59: 109-118, 1979
12. Steiner AL, Goodman AD, Powers SR: Study of a kindred with pheochromocytoma, medullary thyroid carcinoma, hyperparathyroidism, and Cushing's disease: Multiple endocrine neoplasia type 2. Medicine 17: 371-408, 1968
13. Wells SA, Jr., Baylin SB, Linehan WM, Farrell RE, Cox EB, Cooper CW: Provocative agents and the diagnosis of medullary carcinoma of the thyroid gland. Ann Surg 188: 139-141, 1978
14. Wells SA, Jr., Chi DD, Toshima K, Dehner LP, Coffin CM, Dowton B, Ivanovich J, DeBenedetti MK, Dilley WG, Moley JF, Norton JA, Donis-Keller H: Predictive DNA testing and prophylactic thyroidectomy in patients at risk for multiple endocrine neoplasia type 2A. Ann Surg 220: 237-250, 1994
15. Wolfe HJ, Melvin KE, Cervi-Skinner SJ, Saadi AA, Juliar JF, Jackson CE, Tashjian AH, Jr.: C-cell hyperplasia preceding medullary thyroid carcinoma. N Engl J Med 289: 437-441, 1973