Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines

Anti-Cancer Drug Design

Volumn 13, Issue 1, 1998, Pages 19-33

  De Vincenzo, R ^a   Scambia, G ^a   Ferlini, C ^a   Distefano, M ^a   Filippini, P ^a   Riva, A ^b   Bombardelli, E ^b   Pocar, D ^c   Gelmi, M L ^c   Benedetti Panici, P ^a   Mancuso, S ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b INDENA S P A   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Cell cycle analysis; Colchicine analogues; MDR cancer cells

Indexed keywords

COLCHICINE; COLCHICINE DERIVATIVE; DNA FRAGMENT; IDN 5005; IDN 5079; IDN 5080; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL CYCLE; COLCHICINE; DRUG RESISTANCE, MULTIPLE; FLUORINE; GROWTH INHIBITORS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 6844258221     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. BONFOCO, F., CECCATELLI, S., MANZO, L. & NICOTERA, P. (1995). Colchicine induces apoptosis in cerebella r granule cells. Experimental Cell Research, 218, 189.
2. BOYE, O. & BROSSI, A. (1992). Tropolonic colchicum alkaloids and allo congeners. In The Alkaloids. Brossi, A. (ed.), Vol. 41, p. 125. Academic Press: New York.
3. BROSSI, A., YEH, H.J.C., CHRZANOWSKA, M., WOLFF, J., HAMEL, E., LIN, C.M., QUINN, F., SUFFNESS, M. & SILVERTON, J. (1988). Colchicine and its analogues: recent findings. Medicinal Research Reviews, 8, 77.
4. CAPRARO, H.G. & BROSSI, A. (1984). Tropolonic colchicum alkaloids. In The alkaloids. Brossi, A. (ed.), Vol. 23, p. 1. Academic Press: New York.
5. CORTESE, F., BHATTACHARYYA, B. & WOLFF, J. (1977). Podophyllotoxin as a probe for the colchicine binding site of tubulin. Journal of Biological Chemistry, 252, 1134.
6. DARZYNKIEWICZ, Z., BRUNO, S., DEL BINO. G., GORCZYCA, W., HOTZ, M.A., LASSOTA, P. & TRAGANOS, F. (1992). Features of apoptotic cells measured by flow cytometry. Cytometry, 13, 795.
7. FAKIH, M., YAGODA, A., REPLOGE, T., LEHR, J.E. & PIENTA, K J (1995) Inhibition of prostate cancer growth by estramustine and colchicine. Prostate, 26, 310.
8. FERLINI, C., DI CESARE, S., RAINALDI, G., MALORNI, W., SAMOGGIA, P., BISELLI, R. & FATTOROSSI, A. (1996). A flow cytometric analysis of early phases of apoptosis by cellular and nuclear techniques. Cytometry, 24, 106.
9. HASTIE, S.B. (1991). Interaction of colchicine with tubulin. Pharmacology Therapeutics, 51, 377.
10. KEREKES, P., SHARMA, P.D, BROSSI, A., CHIGNELL, C.F. & QUINN, F.R. (1985). Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetyl thiocolchicines, N-(alkoxycarbonyl)-deacetylthiocolchicines, and O-ethyldemethylthiocolchicine. New synthesis of thiodemecolcine and antileukaemic effects of 2-demethyl- and 3-demethylthiocolchicine. Journal of Medicinal Chemistry, 28, 1204.
11. MOSCOW, J.A. & COWAN, K.H. (1988). Multidrug resistance. Journal of the National Cancer Institute, 80, 14.
12. QUINN, F.R. &. BEISLER, J.A (1981). Quantitative structure-activity relationships of colchicines against P388 leukaemia in mice. Journal of Medicinal Chemistry, 24, 251.
13. RINGEL, I., JAFFE, D., ALERHAND, S., BOYE, O., MUZAFFAR, A. & BROSSI, A, (1991). Fluorinated Colchicinoids: antitubulin and cytotoxic properties. Journal of Medicinal Chemistry, 34, 3334.
14. SCAMBIA, C., RANELLETTI, F. O., BENEDETTI PANICI, P., DE VINCENZO, R., BONANNO, C., FERRANDINA, C., PIANTELLI, M., BUSSA, S., RUMI, C., CIANFRIGLIA, P. & MANCUSO, S. (1994). Quercetin potentiates the effect of Adriamycin in a multidrug resistant MCF-7 human breast cancer cell line: P-glycoprotein as a possible target. Cancer Chemotherapy and Pharmacology, 94, 459.
15. SHERWOOD, S., SHERIDAN, J.P. & SCHIMKE, R.T. (1994). Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells. Experimental Cell Research, 215, 373.
16. SUN, L., MCPHAIL, A.T., HAMEL, E., LIN, C.M., HASTIE, S.B., CHANG, J.J. & LEE, K.H. (1993a). Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methy1]-1, 2, 3-trimethoxy-9-(methylthio)-8H-cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents. Journal of Medicinal Chemistry, 36, 544.
17. SUN, L., HAMEL, E., LIN, C.M., HASTIE, S.B., PYLUCH, A. & LEE, K.H. (1993b). Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl, N-aroyl, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds. Journal of Medicinal Chemistry, 36, 1474.
18. TANG WAI, D.F., BROSSI, A., ARNOLD, L.D. & GROS, P. (1993). The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance. Biochemistry, 32, 6470.
19. TSUKIDATE, K., YAMAMOTO, K., SNYDER, J.W. & FARBER, J.L. (1993). Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. American Journal of Pathology, 143, 918.