Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers

Journal of Medicinal Chemistry

Volumn 40, Issue 26, 1997, Pages 4281-4289

  Hu, Lain Yen ^a,b   Quo, Junqing ^a   Magar, Sharad S ^a   Fischer, James B ^a   Burke Howie, Kathleen J ^a   Durant, Graham J ^a  

^a CeNeS Pharmaceuticals plc   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTIGANEL; DIZOCILPINE; GUANIDINE DERIVATIVE; ION CHANNEL; N (2,5 DIBROMOPHENYL) N' (3 ETHYLPHENYL) N' METHYLGUANIDINE; N [2 BROMO 5 (METHYLTHIO)PHENYL] N' (3 ETHYLPHENYL) N' METHYLGUANIDINE; N ALLYLNORMETAZOCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; TENOCYCLIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BRAIN; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; ION CHANNELS; METHYLGUANIDINE; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; PROTEIN BINDING; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 6844257516     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970459c     Document Type: Article

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