Nm23 gene expression in gastric carcinoma: An immunohistochemical study

Australian and New Zealand Journal of Surgery

Volumn 68, Issue 3, 1998, Pages 180-182

  Yeung, P ^a   Soon Lee, C ^b   Marr, P ^c   Sarris, M ^c   Fenton Lee, D ^a  

^a SUTHERLAND HOSPITAL   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c ST GEORGE HOSPITAL   (Australia)

Author keywords

Cancer; Gastric carcinoma; Genes; Immunohistochemistry; Metastasis; Nm23; Tumour suppressor

Indexed keywords

GENE PRODUCT; MONOCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; METASTASIS; STOMACH CARCINOMA; STOMACH MUCOSA; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

EID: 6844249436     PISSN: 00048682     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1445-2197.1998.tb04740.x     Document Type: Article

References (17)

1. Steeg PS, Bevilacqua G, Kopper L et al. Evidence for a novel gene associated with low tumor metastatic potential. J. Natl Cancer Inst. 1988; 80: 200-4.
2. Stahl JA, Leone A, Rosengard AM, Porter L, Richter King C, Steeg PS. Identification of a second human nm23 gene, nm23H-2. Cancer Res. 1991; 51: 445-9.
3. Nickerson JA, Wells WW. The microtubule-associated nucleoside diphosphate kinase. J. Biol. Chem. 1984; 259: 11297-304.
4. Teng DHF, Engele CM, Vankatesh TR. A product of the prune locus of Drosophilia is similar to mammalian GTPase activating protein. Nature 1991; 353: 437-40.
5. Kantor JD, McCormick B, Steeg PS, Zetter BR. Inhibition of cell motility after nm23 transfection of human and murine tumor cells. Cancer Res. 1993; 53: 1971-3.
6. Kodera Y, Isobe K, Yamauchi M et al. Expression of nm23 H-1 RNA levels in human gastric cancer tissues: A negative correlation with nodal metastasis. Cancer 1994; 73: 259-65.
7. Bevilacqua G, Sobel ME, Liotta LA, Steeg PS. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res. 1989; 49: 5185-90.
8. Barnes R, Masood S, Barker E et al. Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. Am. J. Pathol. 1991; 139: 245-50.
9. Martinez JA, Prevot S, Nordlinger B et al. Overexpression of nm23-H1 and nm23-H2 genes in colorectal carcinomas and loss of nm23-H1 expression in advanced tumour stages. Gut 1995; 37: 712-20.
10. Florenes VA, Aamdal S, Myklebost O et al. Levels of nm23 messenger RNA in metastatic malignant melanomas: Inverse correlation to disease progression. Cancer Res. 1992; 52: 6088-91.
11. Lee CS, Redshaw A, Boag G. nm23-H1 protein immunoreactivity in laryngeal carcinoma. Cancer 1996; 77: 2246-50.
12. Sawan A, Lascu I, Veron M et al. NDP-K/nm23 expression in human breast cancer in relation to relapse, survival, and other prognostic factors: an immunohistochemical study. J. Pathol. 1994; 172: 27-34.
13. Zou M, Shi Y, Al-Sedairy S, Farid NR. High levels of Nm23 gene expression in advanced stage of thyroid carcinomas. Br. J. Cancer 1993; 68: 385-8.
14. Haut M, Steeg PS, Wilson JKV, Markowitz SD. Induction of nm23 gene expression in human colonic neoplasms and equal expression in colon tumors of high and low metastatic potential. J. Natl Cancer Inst. 1991; 83: 712-16.
15. Nakayama H, Yasui W, Yokozaki H, Tahara E. Reduced expression of nm23 is associated with metastasis of human gastric carcinomas. Jpn. J. Cancer Res. 1993; 84: 184-90.
16. Royds JA, Cross SS, Silcocks PB et al. Nm23 'anti-metastatic' gene product expression in colorectal carcinoma. J. Pathol. 1994; 172: 261-6.
17. Lee CS, Pirdas-Zivcic A. nm23-H1 protein immunoreactivity in cancers of the gallbladder, extrahepatic bile ducts and ampulla of Vater. Pathology 1994; 26: 448-52.