A cross-over medication trial for patients with autosomal-dominant hypertension with brachydactyly

Kidney International

Volumn 53, Issue 1, 1998, Pages 167-172

  Schuster, Herbert ^b   Toka, Okan ^b   Toka, Hakan R ^b   Busjahn, Andreas ^b   Öztekin, Özgür ^b   Wienker, Thomas F ^b   Bilginturan, Nihat ^b   Bähring, Sylvia ^b   Skrabal, Falko ^b   Haller, Hermann ^b   Luft, Friedrich C ^a  

^a FRANZ VOLHARD CLINIC   (Germany)

^b NONE

Author keywords

Anti hypertensive therapy; Genetics; Hypertension; Monogenic hypertension; Salivary electrolytes

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CHLORIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXAZOSIN; ELECTROLYTE; FELODIPINE; HYDROCHLOROTHIAZIDE; METOPROLOL; MOXONIDINE; PLACEBO; POTASSIUM; RAMIPRIL; SODIUM;

ADOLESCENT; ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BRACHYDACTYLY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ELECTROLYTE INTAKE; ELECTROLYTE TRANSPORT; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

EID: 6844242322     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00732.x     Document Type: Article

References (27)

1. LIFTON RP, DLUHY RG, POWERS M, RICH GM, COOK S, ULICK S, LALOUEL JM: A chimaeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 355:262-265, 1992
2. SHIMKETS RA, WARNOCK DG, BOSITIS CM, NELSON-WILLIAMS C, HANSSON JH, SCHAMBELAN M, GILL JR, ULICK S, MILORA RV, FINDLING JW, CANESSA CM, ROSSIER BC, LIFTON RP: Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell 79:407-414, 1994
3. MUNE T, WHITE PC: Apparent mineralocorticoid excess: Genotype is correlated with biochemical phenotype. Hypertension 27:1193-1199, 1996
4. LIFTON RP: Molecular genetics of human blood pressure variation. Science 272:676-680, 1996
5. BILGINTURAN N, ZILELI S, KARACADAG S, PIMAR T: Hereditary brachydactyly associated with hypertension. J Med Genet 10:253-259, 1973
6. SCHUSTER H, WIENKER TF, BÄHRING S, BILGINTURAN N, TOKA HR, NEITZEL H, JESCHKE E, TOKAN O, GILBERT D, LOWE A, OTT J, HALLER H, LUFT FC: Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nature Genet 13:98-100, 1996
7. SCHUSTER H, WIENKER TF, TOKA HR, BÄHRING S, JESCHKE E, TOKA O, BUSJAHN A, HEMPEL A, TAHLHAMMER C, OELKERS W, KUNZE J, BILGINTURAN N, HALLER H, LUFT FC: Autosomal dominant hypertension and brachydactyly in a Turkish kindred resembles essential hypertension. Hypertension 28:1085-1092, 1996
8. ZANCHETTI A, CHALMERS J, ARAKAWA K, GYAREAS I, HAMET P, HANSSON L, JULIUS S, MACMAHON S, MANCIA G, MENARD J, OMAE T, REID J, SAFAR M: Guidelines for the management of mild hypertension: Memorandum from a WHO/ISH meeting. ISH Hypertension News 1993
9. REPORT OF THE SECOND TASK FORCE ON BLOOD PRESSURE CONTROL IN CHILDREN-1987: Task Force on Blood Pressure Control in Children. National Heart, Lung, and Blood Institute, Bethesda, MD. Pediatrics 79:1-25, 1987
10. SKRABAL F, HERHOLZ H, NEUMAYR M, HAMBERGER L, LEDOCHOWSKI M, SPORER H, HÖRTNAGL H, SCHWARZ S, SCHÖNITZER D: Salt sensitivity in humans is linked to enhanced sympathetic responsiveness and to enhanced proximal tubular reabsorption. Hypertension 6:152-158, 1984
11. WHITE WB, LUND-JOHANSEN P, WEISS S, OMVIK P, INDURKHYA N: The relationships between casual and ambulatory blood pressure measurements and central hemodynamics in essential human hypertension. J Hypertens 12:1075-1081, 1994
12. NEATON JD, GRIMM RH, PRINEAS RJ, STAMLER J, GRANDITS GA, ELMER PJ, CUTLER JA, FLACK JM, SCHOENBERGER JA, MCDONALD R, LEWIS CE, LIEBSON PR FOR THE MILD HYPERTENSION STUDY RESEARCH GROUP: Treatment of mild hypertension study: Final results. JAMA 270:713-724, 1993
13. RICH GM, ULICK S, COOK S, WANG JZ, LIFTON RP, DLUHY RG: Glucocorticoid-remediable aldosteronism in a large kindred: Clinical spectrum and diagnosis using a characteristic biochemical phenotype. Ann Intern Med 116:813-820, 1992
14. LIDDLE GW, BLEDSOE T, COPPAGE WS: A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans Assoc Am Phys 76:199-213, 1963
15. WHITE PC: Inherited forms of mineralocorticoid hypertension. Hypertension 28:927-936, 1996
16. INTERSALT COOPERATIVE RESEARCH GROUP: Intersalt: An international study of electrolyte excretion and blood pressure. Results for 24 hours urinary sodium and potassium excretion. Br Med J 297:319-328, 1988
17. FREIS ED: The efficacy and safety of diuretics in treating hypertension. Ann Intern Med 122:223-226, 1995
18. LINAS SL: The role of potassium in the pathogenesis and treatment of hypertension. Kidney Int 39:771-786, 1991
19. BUCHER HC, COOK RJ, GUYATT GH, LANG JD, COOK DJ, HATALA R, HUNT DL: Effects of dietary calcium supplementation on blood pressure: A meta-analysis of randomized controlled trials. JAMA 275:1016-1022, 1996
20. KHAW K-T, BARRETT-CONNER E: Dietary potassium and stroke-associated mortality. N Engl J Med 316:235-240, 1987
21. BÄHRING S, NAGAI T, TOKA HR, NIZ C, TOKA O, AYDIN A, WIENKER T, SCHUSTER H, LUFT FC: Narrowing the search for the gene causing brachydactyly and hypertension with help from a deletion syndrome on chromosome 12p. Am J Hum Genet 60:732-735, 1997
22. GOLLASCH M, RIED C, BYCHKOV R, LUFT FC, HALLER H: Potassium currents in single smooth muscle cells of human coronary arteries. Circ Res 78:676-688, 1996
23. CHUTKOW WA, SIMON MC, LEBEAU MM, BURANT CF: Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes 45:1439-1445, 1996
24. 2+-activated Cl channels in mammalian cardiac myocytes. Circ Res 81:101-109, 1997
25. NARAGHI R, SCHUSTER H, TOKA HR, BÄHRING S, TOKA O, ÖZTEKIN BILGINTURAN N, KNOBLAUCH H, WIENKER TF, BUSJAHN A, HALLER H, FAHLBUSCH R, LUFT FC: Neurovascular compression at the ventrolateral medulla in autosomal dominant hypertension. Stroke 28:1749-1754, 1997
26. NARAGHI R, GAAB MR, WALTER GF, KLEINEBERG B: Arterial hypertension and neurovascular compression at the ventrolateral medulla: A comparative microanatomical and pathological study. J Neurosurg 77:103-112, 1992
27. NARAGHI R, GEIGER H, CRNAC J, HUK W, FAHLBUSCH R, ENGELS G, LUFT FC: Posterior fossa neurovascular anomalies in essential hypertension. Lancet 344:1466-1470, 1994