Endocrinological abnormalities in angiotensinogen-gene knockout mice: Studies of hormonal responses to dietary salt loading

Journal of Hypertension

Volumn 16, Issue 3, 1998, Pages 285-289

  Umemura, Satoshi ^a   Kihara, Minoru ^a   Sumida, Youichi ^a   Yabana, Machiko ^a   Ishigami, Tomoaki ^a   Tamura, Kouichi ^a   Nyui, Nobuo ^a   Hibi, Kiyoshi ^a   Murakami, Kazuo ^b   Fukamizu, Akiyoshi ^b   Ishii, Masao ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Adrenaline; Angiotensin II; Angiotensinogen; Gene targetting; Noradrenaline; Salt loading; Vasopressin

Indexed keywords

ADRENALIN; ALDOSTERONE; ANGIOTENSIN; ANGIOTENSINOGEN; CREATININE; DOPAMINE; ELECTROLYTE; HORMONE; HYPERTENSIVE FACTOR; NORADRENALIN; SODIUM ION; VASOPRESSIN;

ADRENALIN URINE LEVEL; ALDOSTERONE URINE LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CATECHOLAMINERGIC SYSTEM; CONTROLLED STUDY; CREATININE URINE LEVEL; DOPAMINE URINE LEVEL; ENDOCRINE DISEASE; FLUID BALANCE; HORMONE RESPONSE; HYPOTENSION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NORADRENALIN URINE LEVEL; POLYURIA; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SALT INTAKE; SALT LOADING; SODIUM BALANCE; SURVIVAL; SYSTOLIC BLOOD PRESSURE; URINARY EXCRETION; WEANING;

EID: 6844237656     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816030-00005     Document Type: Article

References (18)

1. Tanimoto K, Sugiyama F, Goto Y, Ishida J, Takimoto E, Yagami K, et al. Angiotensinogen-deficient mice with hypotension. J Biol Chem 1994; 269:31334-31337.
2. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, et al. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 1995; 92:2735-2739.
3. Niimura F, Labosky PA, Kakuchi J, Okubo S, Yoshida H, Oikawa T, et at. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest 1995; 96:2947-2954.
4. Nagata M, Tanimoto K, Fukamizu A, Kon Y, Sugiyama F, Yagami K, et al. Nephrogenesis and renovascular development in angiotensinogen-deficient mice. Lab Invest 1996; 75:745-753.
5. Yabana M, Umemura S, Kihara M, Tamura K, Nyui N, Ishigami T, et al. Altered development of vasculature in the kidney but not in the other main organs in angiotensinogen deficient mice [abstract]. Hypertension 1996; 28:543.
6. Kihara M, Umemura S, Kadota T, Yabana M, Ogawa N, Nyui N, et al. The neuronal isoform of constitutive nitric oxide synthase is upregulated in the macula densa of angiotensinogen gene-knockout mice. Lab Invest 1997; 76:285-294.
7. Nyui N, Tamura K, Mizuno K, Ishigami T, Hibi K, Yabana M, et al. Stretch-induced map kinase activation in cardiomyocytes of angiotensinogen deficient mice. Biochem Biophys Res Commun 1997; 235:36-41.
8. Sumida Y, Umemura S, Tamura K, Kihara M, Kobayashi S, Ishigami T, et al. Increased cardiac angiotensin II receptors in angiotensinogen-deficient mice. Hypertension, in press.
9. Okubo S, Niimura F, Nishimura H, Takemoto F, Fogo A, Matsusaka T, et al. Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion, J Clin Invest 1997; 99:855-860.
10. Guyton AC, Coleman TG, Cowley AW, Scheel KW, Manning RD, Norman RA. Arterial pressure regulation: overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med 1972; 52:584-594.
11. Brooks VL, Osbom JW. Hormonal-sympathetic interactions in long-term regulation of arterial pressure: an hypothesis. Am J Physiol 1995; 268:R1343-R1358.
12. Reid IA. Interactions between Ang II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure. Am J Physiol 1992; 262:E763-E778.
13. Cowley AW, Skelton MM, Merrill DC. Are hypertensive effects of aldosterone, angiotensin, vasopressin, and norepinephrine chronically additive? Hypertension 1986; 8:332-343.
14. Robertson GL, Athar S. The interaction of blood osmolality and blood volume in regulating plasma vasopressin in man. J Clin Endocrinol Metab 1976: 42:613-620.
15. Matsuguchi H, Schmid PG, Orden D, Mark SL. Does vasopressin contribute to salt-induced hypertension in the Dahl strain? Hypertension 1981; 3:174-181.
16. Choi-Kwon S, Baertschi AJ. Splanchnic osmosensation and vasopressin: mechanisms and neural pathways. Am J Physiol 1991; 261:E18-E25.
17. King MS, Baertschi AJ. Central neural pathway mediating splanchnic osmosensation. Brain Res 1991; 550:268-278.
18. Yamaguchi K, Koike M, Hama H. Plasma vasopressin response to peripheral administration of angiotensin in conscious rats. Am J Physiol 1985; 248:R249-R256.