The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system

British Journal of Cancer

Volumn 77, Issue 8, 1998, Pages 1267-1274

  Fox, J C ^a   England, J ^b   White, P ^a   Ellison, G ^a   Callaghan, K ^a   Charlesworth, N R ^a   Hehir, J ^a   McCarthy, T L ^a   Smith Ravin, J ^b   Talbot, I C ^b   Snary, D ^c   Northover, J M A ^b   Newton, C R ^a   Little, S ^a  

^a ASTRAZENECA   (United Kingdom)

^b ST MARK S HOSPITAL   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Amplification refractory mutation system; Diagnosis; Mutation; Oncogene; Screening

Indexed keywords

ARTICLE; CODON; COLORECTAL CARCINOMA; DNA SEQUENCE; EXON; GENE AMPLIFICATION; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MOLECULAR CLONING; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 6844236369     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.212     Document Type: Article

References (65)

1. American Cancer Society (1996) Cancer Facts and Figures - 1996. American Cancer Society
2. Bell SM, Scott N, Cross D, Sagar P, Lewis FA, Blair GE, Dixon MF and Quirke P (1993) Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology 104: 57-64
3. Bos JL (1989) ras Oncogenes in human cancer: a review. Cancer Res 49: 4682-4689
4. Bos JL, Fearon ER, Hamilton SR, Verlaan-De Vries M, Van Boom JH, Van Der Eb AJ and Vogelstein B (1987) Prevalence of ras gene mutations in human colorectal cancers. Nature 327: 293-297
5. Breivik J, Meling GI, Spurkland A, Rognum TO and Gaudernack G (1994) K-ras mutation in colorectal cancer: relations to patient age, sex, and tumour location. Br J Cancer 69: 367-371
6. Burmer J and Loeb LA (1989) Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma. Proc Nail Acad Sci USA 86: 2403-2407
7. Capella G, Cronauer-Mitra S, Pienado MA and Perucho M (1991) Frequency and spectrum of mutations at codon 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect 93: 125-131
8. Carpenter KM, Durrant LG, Morgan K, Bennet D, Hardcastle JD and Kalsheker NA (1996) Greater frequency of K-ras Val-12 mutation in colorectal cancer as detected with sensitive methods. Clin Chem 42: 904-909
9. Cha RS, Zarhl H, Keohavong P and Thilly W (1992) Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene. PCR Method Appl 2: 14-20
10. Chen J and Viola MV (1991) A method to detect ras point mutations in small subpopulations of cells. Anal Biochem 195: 51-56
11. Chou Q, Russell M, Birch DE, Raymond J and Bloch W (1992) Prevention of pre-PCR mis-priming and primer dimerization improves low-copy-number amplifications. Nucleic Acid Res 20: 1717-1723
12. D' Aquila RT, Bechtel LJ, Videler JA, Eron JJ, Gocczyca P and Kaplan JC (1991) Maximizing sensitivity and specificity of PCR by pre-amplification heating. Nucl Acids Res 19: 3749
13. Delattre O, Law DJ, Remvikos Y, Sastre X, Feinberg AP, Olschwang S, Melot T, Salmon RJ, Validire P and Thomas G (1989) Multiple genetic alterations in distal and proximal colorectal cancer. Lancet 2: 353-356
14. Dix BR, Robbins P, Soong R, Jenner D, House AK and Lacopetta B (1994) The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival, Int J Cancer 59: 747-751
15. Dukes CE (1932) The classification of cancer of the rectum. J Pathol Bacterial 35: 323-332
16. Ehlen T and Dubeau L (1989) Detection of ras point mutations by polymerase chain reaction using mutation-specific inosine-containing oligonucleotide primers. Biochem Biophys Res Commun 160: 441-447
17. El-Deiry WS, Nelkin BD, Celano P, Yen RW, Falco JP, Hamilton SR and Baylin SB (1991) High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci USA 88: 3470-3474
18. Fearon ER and Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759-767
19. Ferrie RM, Schwarz MJ, Robertson NH, Vaudin S, Super M, Malone G and Little S (1992) Development, multiplexing and application of ARMS tests for common mutations in the CFTR gene. Am J Hum Genet 51: 251-262
20. Finkelstein SD, Sayegh R, Bakker A, Swalsky P and Steele GD (1993a) Determination of tumor aggressiveness in colorectal cancer by K-ras-2 analysis. Arch Surg 128: 526-532
21. Finkelstein SD, Sayegh R, Christennsen S and Swalsky PA (1993b) Genotypic classification of colorectal adenocarcinoma-biologic behaviour correlates with K-ras-2 mutation type. Cancer 71: 3827-3838
22. Forrester K, Almoguera C, Han K, Grizzle WE and Perucho M (1987) Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327: 298-303
23. Giaretti W, Pujic N, Rapallo A, Nigro S, Di Vinci A, Geido E and Risio M (1995) K-ras G-C and G-T transversions correlate with DNA aneuploidy in colorectal adenomas. Gastroenterology 108: 1040-1047
24. Goldgar DE, Easton DF, Cannon-Albright LA and Skolnick MH (1994) Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Nutl Cancer Inst 86: 1600-1608
25. Green PM, Bentley DR, Mibashan RS, Nilsson IG and Giannelli F (1989) Molecular pathology of Haemophilia B. EMBO J 8: 1067-1072
26. Hasegawa Y, Takeda S, Ichii S, Koizumi K, Maruyama M, Fujii A, Ohta H, Nakajima T, Okuda M, Baba S and Nakamura Y (1995) Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA) Oncogene 10: 1441-1445
27. Hayashi N, Ito I, Yanagisawa A, Kato Y. Nakamori S, Imaoka S, Watanabe H, Ogawa M and Nakamura Y (1995) Genetic diagnosis of lymph-node metastasis in colorectal cancer. Lancet 345: 1257-1259
28. Houlston RS, Collins A, Slack J and Morton NE (1992) Dominant genes for colorectal cancer are not rare. Ann HumGenet 56: 99-103
29. Jones PA and Buckley JD (1990) The role of DNA methylation in cancer. Adv Cancer Res 54: 1-23
30. Kern SE, Fearon ER, Tersmette KWF, Enterline JP, Leppert M, Nakamura Y, White R, Vogelstein B and Hamilton SR (1989) Allelic loss in colorectal carcinoma. J Am Med Assoc 261: 3099-3103
31. Kwok S and Higuchi R (1989) Avoiding false positives with PCR. Nature 339: 237-238
32. Laird PW, Jacksongrusby L, Fazeli A, Dickson SL, Jung WE, Li E, Weinberg RA and Jaenisch R (1995) Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81: 197-205
33. Laurent-Puig P, Olschwang S, Delattre O, Remvikos Y, Asselain B, Melot T, Validire P, Muleris M, Girodet J, Salmon RJ and Thomas G (1992) Survival and acquired genetic alterations in colorectal cancer. Gastroenterology 102: 1136-1141
34. Levi S, Urbano-Ispizua A, Gill R, Thomas DM, Gilbertson J, Foster C and Marshall CJ (1991) Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res 51: 3497-3502
35. Lewis CM, Neuhausen DD, Black FJ, Swensen J, Burt RW, Cannon-Albright LA and Skolnick MH (1996) Genetic heterogeneity and unmapped genes for colorectal cancer. Cancer Res 56: 1382-1388
36. Macklin MT (1960) Inheritance of cancer of the stomach and large intestine in man. J Natl Cancer Inst 24: 551-571
37. Magewu AN and Jones PA (1994) Ubiquitous and tenacious methylation of the CpG site in codon-248 of the p53 gene may explain its frequent appearance as a mutational hot-spot in human cancer. Mol Cell Biol 14: 4225-4232
38. McLellan EA, Owen RA, Stepniewska KA, Sheffield JP and Lemoine NR (1993) High frequency of K-ras mutations in sporadic colorectal adenomas. Gut 34: 392-396
39. Moerkerk P, Arends JW, Van Driel M, De Bruine A, De Goeij A and Ten Kate J (1994) Type and number of Ki-ras point mutations relate to stage of human colorectal cancer. Cancer Res 54: 3376-3378
40. Morrin M, Kelly M, Barrett N and Delaney P (1994) Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance. Gut 35: 1627-1631
41. 1-antitrypsin deficiency by enzymatic amplification of human genomic DNA and direct sequencing of polymerase chain reaction products. Nucleic Acid Res 16: 8233-8243
42. Newton CR, Graham A, Heptinstall LE, Powell SJ, Summers C, Kalsheker N, Smith JC and Markham AF (1989) Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acid Res 17: 2503-2516
43. Offerhaus GJA, De Feyter EP, Cornelisse CJ, Tersmette KWF, Floyd J, Kern SE, Vogelstein B and Hamilton SR (1992) The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma. Gastroenterology 102: 1612-1619
44. Oudejans JJ, Slebos RJC, Zoetmulder FAN, Mooi WJ and Rodenhuis S (1991) Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver, Int J Cancer 49: 875-879
45. Peltomaki P, Aaltonen LA, Sistonen P, Pylkkanene L, Mecklin J-P, Jarvinen H, Green JS, Jass JR, Weber JL, Leach JL, Leach FS, Petersen GM, Hamilton SR, De La Chapelle A and Vogelstein B (1993) Genetic mapping of a locus predisposing to human colorectal cancer. Science 260: 810-812
46. Petersen GM (1995) Genetic epidemiology of colorectal cancer. Eur J Cancer 31A: 1047-1050
47. Ranaldi R, Giocchini AM, Manzin A, Clementi M, Stefania P and Bearzi I (1995) Adenoma-carcinoma sequence of colorectum. Diagn Mol Pathol 4: 198-202
48. Redston MS and Kern SE (1994) Klenow co-sequencing: a method for eliminating 'stops'. Biotechniques 17: 286-288
49. Ries LAG, Miller BA, Hankey BF, Kosary CL, Harras A and Edwards BK (1994) Surveillance. Epidemiology and End Results (SEER) Cancer Statistics Review. 1973-1991: Tables and Graphs, National Cancer Institute. NIH publication no. 94-2789. Bethesda, USA
50. Riley J, Jenner D, Smith JC and Markham AF (1989) Rapid determination of DNA concentration in multiple samples. Nucleic Acid Res 17: 8383
51. Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou J, Drumm MJ, Ianuzzi MC, Collins FS and Tsui L (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1073
52. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY
53. Sharrard RM, Royds JA, Rogers S and Shorthouse AJ (1992) Patterns of methylation of the c-myc gene in human colorectal cancer progression. Br J Cancer 65: 667-672
54. Sidransky D, Tokino T, Hamilton SR, Kinzler KK, Levin B, Frost P and Vogelstein B (1992) Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science 256: 102-105
55. Span M, Moerker PTM, De Goeij AFPM and Arends JW (1996) A detailed analysis of K-ras mutations in relation to tumor progression and survival in colorectal cancer patients. Int J Cancer 69: 241-245
56. Stork P, Loda M, Bosari S, Wiley B, Poppenhusen K and Wolfe H (1991) Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction. Oncogene 6: 857-862
57. Tanaka M, Omura K, Watanabe Y, Oda Y and Nakanishi I (1994) Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity. J Surg Oncol 57: 57-64
58. Urosevic N, Krtolica K, Scaro-Milic A, Knezevic-Usai S and Dujic A (1993) Prevalence of G-to-T trunsversions among K-ras oncogene mutations in human colorectal cancer in Yugoslavia, Int J Cancer 54: 249-254
59. Villa E, Dugani A, Rebeechi AM, Vignoli A, Grottola A, Buttafoco P, Losi L, Perini M, Trande P, Merighi A, Lerose R and Manenti F (1996) Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool. Gastroenterology 110: 1346-1353
60. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, While R, Smits AMM and Bos JL (1988) Genetic alterations during colorectal tumor development. N Engl J Med 319: 525-532
61. Vogelstein B, Fearon ER, Kern SE, Hamilton SR, Preisinger AC, Nakamura Y and White R (1989) Allelotype of colorectal carcinomas. Science 244: 207-211
62. Woolf CM (1958) A genetic study of carcinoma of the large intestine. Am J Hum Genet 10: 42-47
63. Yainada H, Yoshida T, Sakamoto H, Terada M and Sugimura T (1986) Establishment of a human pancreatic adenocarcinoma cell line (PSN-1) with amplifications of both c-myc and activated c-Ki-ras by a point mutation. Biochem Biophys Res Commun 140: 167-173
64. Young G and Levin B (1996) Report of UICC colorectal cancer screening workshop. Int Cancer 65: 567-568
65. Zhao LP and Le Marchand L (1992) An analytical method for assessing patterns of familial aggregation in case-control studies. Genet Epidemiol 9: 141-154