A short (3-day) course of azithromycin tablets versus a 10-day course of amoxycillin-clavulanic acid (co-amoxiclav) in the treatment of adults with lower respiratory tract infections and effects on long-term outcome

International Journal of Antimicrobial Agents

Volumn 9, Issue 3, 1998, Pages 141-146

  Hoepelman, I M ^a,b   Mollers M J ^c   Van Schie, M H ^d   Greefhorst, A P M ^e   Schlosser N J J ^a   Sinninghe Damste E J ^f   Van De Moosdijk, C N F ^g   Dalinghaus, W H ^h   Eland, M E ⁱ   Mol, S J M ^j   Rozenberg Arska, M ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c ZcA Lukas Hospital   (Netherlands)

^d Kendle/U gene Research   (Netherlands)

^e Hosp Streekziekenhuis Midden Twente   (Netherlands)

^f TWENTEBORG HOSPITAL   (Netherlands)

^g ST ANNA HOSPITAL   (Netherlands)

^h Beatrix Hospital   (Netherlands)

ⁱ Merwede Ziekenhuis   (Netherlands)

^j ST JOSEPH HOSPITAL   (Netherlands)

more..

Author keywords

Acute exacerbation of chronic bronchitis; Azithromycin; Co amoxiclav; Lower respiratory tract infection

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AZITHROMYCIN;

ADULT; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL THERAPY; ARTICLE; CHRONIC BRONCHITIS; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; NETHERLANDS; ORAL DRUG ADMINISTRATION; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STREPTOCOCCUS PNEUMONIAE; VIRUS INFECTION;

ADULT; AGED; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BRONCHITIS; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; PNEUMONIA, BACTERIAL; TREATMENT OUTCOME;

EID: 6844222826     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(97)00043-5     Document Type: Article

References (21)

1. Retsema J., Girard A., Schelkly W.et al. Spectrum and mode of action of azithromycin (CP-96,993), a new 15-membered macrolide with improved potency against Gram-negative organisms. Antimicrob. Agents Chemother. 31:1987;1939-1947.
2. Hoepelman I., Schneider M.M.E. Azithromycin: the first of the tissue-selective azalides. Int. J. Antimicrob. Agents. 5:1995;145-167.
3. Neu H.C., Chin N.X., Saha G., Labthavikul P. Comparative in vitro activity of the new oral macrolide azithromycin. Eur. J. Clin. Microbiol. Infect. Dis. 7:1988;541-544.
4. Baldwin D.R., Wise R., Andrews J.M.et al. Azithromycin concentrations at the sites of pulmonary infection. Eur. Respir. J. 3:1990;886-890.
5. Azoulay-Dupuis E., Vallée E., Bedos J.P.et al. Prophylactic and therapeutic activities of azithromycin in a mouse model of pneumococcal pneumonia. Antimicrob. Agents Chemother. 35:1991;1024-1028.
6. Mertens J.C.C., van Barneveld P.W.C., Asin H.R.G.et al. Double-blind randomized study comparing the efficacies and safeties of a short (3-day) course of azithromycin and a 5-day course of amoxicillin in patients with acute exacerbations of chronic bronchitis. Antimicrob. Agents Chemother. 36:1991;1456-1459.
7. Hoepelman A.I.M., Sips A.P., Helmond J.L.M.et al. A single-blind comparison of three-day azithromycin and ten-day co-amoxiclav treatment of acute and lower respiratory tract infections. J. Antimicrob. Chemother. 31(Suppl E):1993;147-152.
8. Anthonisen N.R., Manfreda J., Warren C.P.W.et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann. Intern. Med. 106:1987;196-204.
9. American Thoracic Society. Chronic bronchitis and asthma and pulmonary emphysema. A statement by the committee on Diagnostic Standard for non-Tuberculosis Respiratory Diseases. Am. Rev. Resp. Dis. 1962;85:62-8.
10. National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. NCCLS 10,8: M7-A2. NCCLS, Villanova, PA.
11. Balmes P., Clerc G., Dupont B.et al. Comparative study of azithromycin and amoxicillin/clavulanic acid in the treatment of lower respiratory tract infections. Eur. J. Clin. Microbiol. Infect. Dis. 10:1991;437-439.
12. Dark D. Multicenter evaluation of azithromycin and cefaclor in acute lower respiratory tract infections. Am. J. Med. 91(Suppl A):1991;31S-35S.
13. Bachand R.T. Jr. Comparative study of clarithromycin and ampicillin in the treatment of patients with acute bacterial exacerbations of chronic bronchitis. J. Antimicrob. Chemother. 27(Suppl A):1991;91-100.
14. Rademaker C.M., Sips A.P., Beumer H.M.et al. A double-blind comparison of low-dose of loxacin and amoxycillin/clavulanic acid in acute exacerbations of chronic bronchitis. J. Antimicrob. Chemother. 26(Suppl D):1990;75-81.
15. Chodosh S. Treatment of acute exacerbation of chronic bronchitis: state of the art. Am. J. Med. 91(6A):1991;87S-92S.
16. Gump D.W., Phillips C.A., Forsyth B.R.et al. Role of infection in chronic bronchitis. Am. Rev. Respir. Dis. 113:1976;465-474.
17. Lamy M.E., Pouthier-Simon F., Debacker-Williame E. Respiratory viral infections in hospital patients with chronic bronchitis. Chest. 63:1973;336-341.
18. Roessingh P.H., van Loon A.M., Lammers J.-W.J., Hoepelman I.M. Causative role of intection with viruses and atypical pathogens in acute exacerbations of chronic bronchitis less frequent than expected. Ned. Tijdschr. Geneeskd. 140:1996;2406-2410.
19. Nicotra M.B., Rivera M., Awe R.J. Antibiotic therapy of acute exacerbation of chronic bronchitis: a controlled study using tetracycline. Ann. Intern. Med. 97:1987;18-21.
20. Editorial. Antibiotics for exacerbation of chronic bronchitis. Lancet 1987; ii: 23-24.
21. Saint S., Bent S., Vittinghoff E. Antibiotics in chronic obstructive pulmonary disease: a meta-analysis. J. Am. Med. Assoc. 273:1995;957-960.