-
1
-
-
0034680825
-
The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia
-
Agani FH, Pichiule P, Chávez JC, La Manna J. 2000. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 275:35863-35867.
-
(2000)
J Biol Chem
, vol.275
, pp. 35863-35867
-
-
Agani, F.H.1
Pichiule, P.2
Chávez, J.C.3
La Manna, J.4
-
2
-
-
0036089548
-
Role of nitric oxide in the regulation of HIF-1α expression during hypoxia
-
Agani FH, Puchowicz MA, Chavez JC, Pichiule P, La Manna JC. 2002. Role of nitric oxide in the regulation of HIF-1α expression during hypoxia. Am J Physiol 283:C178-C186.
-
(2002)
Am J Physiol
, vol.283
-
-
Agani, F.H.1
Puchowicz, M.A.2
Chavez, J.C.3
Pichiule, P.4
La Manna, J.C.5
-
3
-
-
1342310736
-
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
-
Almeida A, Moncada S, Bolanos JP. 2004. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol 6:45-51.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 45-51
-
-
Almeida, A.1
Moncada, S.2
Bolanos, J.P.3
-
4
-
-
7944226627
-
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
-
Altenberg B, Greulich KO. 2004. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics 84:1014-1020.
-
(2004)
Genomics
, vol.84
, pp. 1014-1020
-
-
Altenberg, B.1
Greulich, K.O.2
-
5
-
-
13544251744
-
Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line
-
Aminova LR, Chavez JC, Lee J, Ryu H, Kung A, et al. 2005. Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. J Biol Chem 280:3996-4003.
-
(2005)
J Biol Chem
, vol.280
, pp. 3996-4003
-
-
Aminova, L.R.1
Chavez, J.C.2
Lee, J.3
Ryu, H.4
Kung, A.5
-
6
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxiainducible factor
-
Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, et al. 2004. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxiainducible factor. J Biol Chem 279:38458-38465.
-
(2004)
J Biol Chem
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
Tian, Y.M.2
Raval, R.R.3
Turley, H.4
Harris, A.L.5
-
7
-
-
0025114144
-
Lactate compartmentation in hippocampal slices: Evidence for a transporter
-
Assaf HM, Ricci AJ, Whittingham TS, La Manna JC, Ratcheson RA, et al. 1990. Lactate compartmentation in hippocampal slices: Evidence for a transporter. Metab Brain Dis 5:143-154.
-
(1990)
Metab Brain Dis
, vol.5
, pp. 143-154
-
-
Assaf, H.M.1
Ricci, A.J.2
Whittingham, T.S.3
La Manna, J.C.4
Ratcheson, R.A.5
-
8
-
-
0033839757
-
Role of hypoxia-inducible factor-1 in hypoxiainduced ischemic tolerance in neonatal rat brain
-
Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, et al. 2000. Role of hypoxia-inducible factor-1 in hypoxiainduced ischemic tolerance in neonatal rat brain. Ann Neurol 48:285-296.
-
(2000)
Ann Neurol
, vol.48
, pp. 285-296
-
-
Bergeron, M.1
Gidday, J.M.2
Yu, A.Y.3
Semenza, G.L.4
Ferriero, D.M.5
-
9
-
-
0033435198
-
Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain
-
Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. 1999. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci 11:4159-4170.
-
(1999)
Eur J Neurosci
, vol.11
, pp. 4159-4170
-
-
Bergeron, M.1
Yu, A.Y.2
Solway, K.E.3
Semenza, G.L.4
Sharp, F.R.5
-
10
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra E, Benizri E, Ginouves A, Volmat V, Roux D, et al. 2003. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22:4082-4090.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
-
11
-
-
0019390509
-
Developmental changes in metabolism and transport properties of capillaries isolated from rat brain
-
Betz AL, Goldstein GW. 1981. Developmental changes in metabolism and transport properties of capillaries isolated from rat brain. J Physiol 312:365-376.
-
(1981)
J Physiol
, vol.312
, pp. 365-376
-
-
Betz, A.L.1
Goldstein, G.W.2
-
12
-
-
0024450787
-
Metabolic anatomy of brain: A comparison of regional capillary density, glucose metabolism, and enzyme activities
-
Borowsky IW, Collins RC. 1989. Metabolic anatomy of brain: A comparison of regional capillary density, glucose metabolism, and enzyme activities. J Comp Neurol 288:401-413.
-
(1989)
J Comp Neurol
, vol.288
, pp. 401-413
-
-
Borowsky, I.W.1
Collins, R.C.2
-
13
-
-
10444223878
-
The hypoxia-inducible factor and tumor progression along the angiogenic pathway
-
Brahimi-Horn MC, Pouyssegur J. 2005. The hypoxia-inducible factor and tumor progression along the angiogenic pathway. Int Rev Cytol 242:157-213.
-
(2005)
Int Rev Cytol
, vol.242
, pp. 157-213
-
-
Brahimi-Horn, M.C.1
Pouyssegur, J.2
-
14
-
-
0032947296
-
Nitric oxide and mitochondrial respiration
-
Brown GC. 1999. Nitric oxide and mitochondrial respiration. Biochim Biophys Acta 1411:351-369.
-
(1999)
Biochim Biophys Acta
, vol.1411
, pp. 351-369
-
-
Brown, G.C.1
-
15
-
-
0028134892
-
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
-
Brown GC, Cooper CE. 1994. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356:295-298.
-
(1994)
FEBS Lett
, vol.356
, pp. 295-298
-
-
Brown, G.C.1
Cooper, C.E.2
-
16
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. 2001. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294:1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
17
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
Bunn HF, Poyton RO. 1996. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76:839-885.
-
(1996)
Physiol Rev
, vol.76
, pp. 839-885
-
-
Bunn, H.F.1
Poyton, R.O.2
-
18
-
-
0033763820
-
Expression of hypoxic inducible factor 1α in the brain of rats during chronic hypoxia
-
Chávez JC, Agani F, Pichiule P, La Manna JC. 2000. Expression of hypoxic inducible factor 1α in the brain of rats during chronic hypoxia. J Appl Physiol 89:1937-1942.
-
(2000)
J Appl Physiol
, vol.89
, pp. 1937-1942
-
-
Chávez, J.C.1
Agani, F.2
Pichiule, P.3
La Manna, J.C.4
-
19
-
-
0037109768
-
Activation of hypoxia inducible factor-1 in the rat cerebral cortex after transient global ischemia: Potential role of insulin-like growth factor-1
-
Chavez JC, LaManna JC. 2002. Activation of hypoxia inducible factor-1 in the rat cerebral cortex after transient global ischemia: Potential role of insulin-like growth factor-1. J Neurosci 22:8922-8931.
-
(2002)
J Neurosci
, vol.22
, pp. 8922-8931
-
-
Chavez, J.C.1
La Manna, J.C.2
-
20
-
-
0037223713
-
Hypoxia-inducible factor-1α accumulation in the rat brain in response to hypoxia and ischemia is attenuated during aging
-
Chavez JC, LaManna JC. 2003. Hypoxia-inducible factor-1α accumulation in the rat brain in response to hypoxia and ischemia is attenuated during aging. Adv Exp Med Biol 510:337-341.
-
(2003)
Adv Exp Med Biol
, vol.510
, pp. 337-341
-
-
Chavez, J.C.1
La Manna, J.C.2
-
21
-
-
0028997104
-
Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia
-
Chávez JC, Pichiule P, Boero J, Arregui A. 1995. Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia. Neurosci Lett 193:169-172.
-
(1995)
Neurosci Lett
, vol.193
, pp. 169-172
-
-
Chávez, J.C.1
Pichiule, P.2
Boero, J.3
Arregui, A.4
-
22
-
-
0025320647
-
The regulation and modulation of pH in the nervous system
-
Chesler M. 1990. The regulation and modulation of pH in the nervous system. Prog Neurobiol 34:401-427.
-
(1990)
Prog Neurobiol
, vol.34
, pp. 401-427
-
-
Chesler, M.1
-
23
-
-
10944237677
-
Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase
-
Cidad P, Almeida A, Bolanos JP. 2004. Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase. Biochem J 384:629-636.
-
(2004)
Biochem J
, vol.384
, pp. 629-636
-
-
Cidad, P.1
Almeida, A.2
Bolanos, J.P.3
-
24
-
-
0036176751
-
Positron emission tomography scanning: Current and future applications
-
Czernin J, Phelps ME. 2002. Positron emission tomography scanning: Current and future applications. Annu Rev Med 53:89-112.
-
(2002)
Annu Rev Med
, vol.53
, pp. 89-112
-
-
Czernin, J.1
Phelps, M.E.2
-
25
-
-
2642542967
-
Endogenous 2-oxoacids differentially regulate expression of oxygen sensors
-
Dalgard CL, Lu H, Mohyeldin A, Verma A. 2004. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem J 380:419-424.
-
(2004)
Biochem J
, vol.380
, pp. 419-424
-
-
Dalgard, C.L.1
Lu, H.2
Mohyeldin, A.3
Verma, A.4
-
26
-
-
0025994345
-
Protons in ischemia: Where do they come from; where do they go to?
-
Dennis SC, Gevers W, Opie LH. 1991. Protons in ischemia: Where do they come from; where do they go to? J Mol Cell Cardiol 23:1077-1086.
-
(1991)
J Mol Cell Cardiol
, vol.23
, pp. 1077-1086
-
-
Dennis, S.C.1
Gevers, W.2
Opie, L.H.3
-
27
-
-
0037727912
-
Neighborly interactions of metabolically-activated astrocytes in vivo
-
Dienel GA, Cruz NF. 2003. Neighborly interactions of metabolically- activated astrocytes in vivo. Neurochem Int 43:339-354.
-
(2003)
Neurochem Int
, vol.43
, pp. 339-354
-
-
Dienel, G.A.1
Cruz, N.F.2
-
28
-
-
2442532184
-
Nutrition during brain activation: Does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought?
-
Dienel GA, Cruz NF. 2004. Nutrition during brain activation: Does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought? Neurochem Int 45:321-351.
-
(2004)
Neurochem Int
, vol.45
, pp. 321-351
-
-
Dienel, G.A.1
Cruz, N.F.2
-
29
-
-
0027216810
-
Glycogen in astrocytes: Possible function as lactate supply for neighboring cells
-
Dringen R, Gebhardt R, Hamprecht B. 1993. Glycogen in astrocytes: Possible function as lactate supply for neighboring cells. Brain Res 623:208-214.
-
(1993)
Brain Res
, vol.623
, pp. 208-214
-
-
Dringen, R.1
Gebhardt, R.2
Hamprecht, B.3
-
30
-
-
0033637362
-
Noninvasive assessment of cerebral oxygenation during acclimation to hypobaric hypoxia
-
Dunn JF, Grinberg O, Roche M, Nwaigwe CI, Hou HG, et al. 2000. Noninvasive assessment of cerebral oxygenation during acclimation to hypobaric hypoxia. J Cereb Blood Flow Metab 20:1632-1635.
-
(2000)
J Cereb Blood Flow Metab
, vol.20
, pp. 1632-1635
-
-
Dunn, J.F.1
Grinberg, O.2
Roche, M.3
Nwaigwe, C.I.4
Hou, H.G.5
-
31
-
-
0028805375
-
Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences
-
Ebert BL, Firth JD, Ratcliffe PJ. 1995. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences. J Biol Chem 270:29083-29089.
-
(1995)
J Biol Chem
, vol.270
, pp. 29083-29089
-
-
Ebert, B.L.1
Firth, J.D.2
Ratcliffe, P.J.3
-
32
-
-
0019414837
-
Age-related changes in enzymes of rat brain. 1. Enzymes of glycolysis, the pentose phosphate pathway and lipogenesis
-
El-Hassan A, Zubairu S, Hothersall JS, Greenbaum AL. 1981. Age-related changes in enzymes of rat brain. 1. Enzymes of glycolysis, the pentose phosphate pathway and lipogenesis. Enzyme 26:107-112.
-
(1981)
Enzyme
, vol.26
, pp. 107-112
-
-
El-Hassan, A.1
Zubairu, S.2
Hothersall, J.S.3
Greenbaum, A.L.4
-
33
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, et al. 2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64:3892-3899.
-
(2004)
Cancer Res
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
-
34
-
-
0033118983
-
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
-
Ema M, Hirota K, Mimura J, Abe H, Yodoi J, et al. 1999. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 18:1905-1914.
-
(1999)
EMBO J
, vol.18
, pp. 1905-1914
-
-
Ema, M.1
Hirota, K.2
Mimura, J.3
Abe, H.4
Yodoi, J.5
-
35
-
-
17944375360
-
C elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, et al. 2001. C.elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
-
36
-
-
0028359320
-
Oxygenrelated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 30 enhancer
-
Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. 1994. Oxygenrelated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 30 enhancer. Proc Natl Acad Sci USA 91:6496-6500.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 6496-6500
-
-
Firth, J.D.1
Ebert, B.L.2
Pugh, C.W.3
Ratcliffe, P.J.4
-
37
-
-
0029101515
-
Hypoxic regulation of lactate dehydrogenase A
-
Firth JD, Ebert BL, Ratcliffe PJ. 1995. Hypoxic regulation of lactate dehydrogenase A. J Biol Chem 270:21021-21027.
-
(1995)
J Biol Chem
, vol.270
, pp. 21021-21027
-
-
Firth, J.D.1
Ebert, B.L.2
Ratcliffe, P.J.3
-
38
-
-
1842627462
-
SM-20, EGL-9, and the EGLN family of hypoxiainducible factor prolyl hydroxylases
-
Freeman RS, Hasbani DM, Lipscomb EA, Straub JA, Xie L. 2003. SM-20, EGL-9, and the EGLN family of hypoxiainducible factor prolyl hydroxylases. Mol Cells 16:1-12.
-
(2003)
Mol Cells
, vol.16
, pp. 1-12
-
-
Freeman, R.S.1
Hasbani, D.M.2
Lipscomb, E.A.3
Straub, J.A.4
Xie, L.5
-
39
-
-
0032748767
-
The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice
-
Frenkel-Denkberg G, Gershon D, Levy AP. 1999. The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice. FEBS Lett 462:341-344.
-
(1999)
FEBS Lett
, vol.462
, pp. 341-344
-
-
Frenkel-Denkberg, G.1
Gershon, D.2
Levy, A.P.3
-
40
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, et al. 2002. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277:38205-38211.
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
-
41
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. 2004. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891-899.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
42
-
-
2442430224
-
Hypoxia up-regulates triosephosphate isomerase expression via a HIF-dependent pathway
-
Gess B, Hofbauer KH, Deutzmann R, Kurtz A. 2004. Hypoxia up-regulates triosephosphate isomerase expression via a HIF-dependent pathway. Pflugers Arch 448:175-180.
-
(2004)
Pflugers Arch
, vol.448
, pp. 175-180
-
-
Gess, B.1
Hofbauer, K.H.2
Deutzmann, R.3
Kurtz, A.4
-
43
-
-
0017764326
-
Generation of protons by metabolic processes in heart cells
-
Gevers W. 1977. Generation of protons by metabolic processes in heart cells. J Mol Cell Cardiol 9:867-874.
-
(1977)
J Mol Cell Cardiol
, vol.9
, pp. 867-874
-
-
Gevers, W.1
-
44
-
-
0032741858
-
Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene
-
Graven KK, Yu Q, Pan D, Roncarati JS, Farber HW. 1999. Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim Biophys Acta 1447:208-218.
-
(1999)
Biochim Biophys Acta
, vol.1447
, pp. 208-218
-
-
Graven, K.K.1
Yu, Q.2
Pan, D.3
Roncarati, J.S.4
Farber, H.W.5
-
45
-
-
0036468251
-
Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): Evidence of an anabolic role for the HIF-1 pathway
-
Griffiths JR, McSheehy PM, Robinson SP, Troy H, Chung YL, et al. 2002. Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): Evidence of an anabolic role for the HIF-1 pathway. Cancer Res 62:688-695.
-
(2002)
Cancer Res
, vol.62
, pp. 688-695
-
-
Griffiths, J.R.1
McSheehy, P.M.2
Robinson, S.P.3
Troy, H.4
Chung, Y.L.5
-
46
-
-
0038716692
-
Opportunities for studying cancer by metabolomics: Preliminary observations on tumors deficient in hypoxia-inducible factor 1
-
Griffiths JR, Stubbs M. 2003. Opportunities for studying cancer by metabolomics: Preliminary observations on tumors deficient in hypoxia-inducible factor 1. Adv Enzyme Regul 43:67-76.
-
(2003)
Adv Enzyme Regul
, vol.43
, pp. 67-76
-
-
Griffiths, J.R.1
Stubbs, M.2
-
47
-
-
0035793584
-
Molecular mechanism of hypoxia-inducible factor 1alpha-p300 interaction. A leucine-rich interface regulated by a single cysteine
-
Gu J, Milligan J, Huang LE. 2001. Molecular mechanism of hypoxia-inducible factor 1alpha-p300 interaction. A leucine-rich interface regulated by a single cysteine. J Biol Chem 276:3550-3554.
-
(2001)
J Biol Chem
, vol.276
, pp. 3550-3554
-
-
Gu, J.1
Milligan, J.2
Huang, L.E.3
-
48
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha
-
Hagen T, Taylor CT, Lam F, Moncada S. 2003. Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha. Science 302:1975-1978.
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
Moncada, S.4
-
49
-
-
0030597075
-
Time course and reversibility of the hypoxia-induced alterations in cerebral vascularity and cerebral capillary glucose transporter density
-
Harik N, Harik SI, Kuo N-T, Sakai K, Przybylski RJ, et al. 1996. Time course and reversibility of the hypoxia-induced alterations in cerebral vascularity and cerebral capillary glucose transporter density. Brain Res 737:335-338.
-
(1996)
Brain Res
, vol.737
, pp. 335-338
-
-
Harik, N.1
Harik, S.I.2
Kuo, N.-T.3
Sakai, K.4
Przybylski, R.J.5
-
50
-
-
0028095189
-
Hypoxia increases glucose transport at blood-brain barrier in rats
-
Harik SI, Behmand RA, LaManna JC. 1994. Hypoxia increases glucose transport at blood-brain barrier in rats. J Appl Physiol 77:896-901.
-
(1994)
J Appl Physiol
, vol.77
, pp. 896-901
-
-
Harik, S.I.1
Behmand, R.A.2
La Manna, J.C.3
-
51
-
-
0029101156
-
Brain glucose metabolism in hypobaric hypoxia
-
Harik SI, Lust WD, Jones SC, Lauro KL, Pundik S, et al. 1995. Brain glucose metabolism in hypobaric hypoxia. J Appl Physiol 79:136-140.
-
(1995)
J Appl Physiol
, vol.79
, pp. 136-140
-
-
Harik, S.I.1
Lust, W.D.2
Jones, S.C.3
Lauro, K.L.4
Pundik, S.5
-
52
-
-
20244378834
-
Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage
-
Helton R, Cui J, Scheel JR, Ellison JA, Ames C, et al. 2005. Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci 25:4099-4107.
-
(2005)
J Neurosci
, vol.25
, pp. 4099-4107
-
-
Helton, R.1
Cui, J.2
Scheel, J.R.3
Ellison, J.A.4
Ames, C.5
-
53
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J. 2003. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278:30772-30780.
-
(2003)
J Biol Chem
, vol.278
, pp. 30772-30780
-
-
Hirsila, M.1
Koivunen, P.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
55
-
-
0021111735
-
Protons and anaerobiosis
-
Hochachka PW, Mommsen TP. 1983. Protons and anaerobiosis. Science 219:1391-1397.
-
(1983)
Science
, vol.219
, pp. 1391-1397
-
-
Hochachka, P.W.1
Mommsen, T.P.2
-
56
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. 2003. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 23:9361-9374.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
57
-
-
0037131159
-
Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
-
Huang J, Zhao Q, Mooney SM, Lee FS. 2002. Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J Biol Chem 277:39792-39800.
-
(2002)
J Biol Chem
, vol.277
, pp. 39792-39800
-
-
Huang, J.1
Zhao, Q.2
Mooney, S.M.3
Lee, F.S.4
-
58
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, Bunn HF. 1998. Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95:7987-7992.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
59
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
Ivan M, Haberberger T, Gervasi DC, Michelson KS, Gunzler V, et al. 2002. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci USA 99:13459-13464.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
Michelson, K.S.4
Gunzler, V.5
-
63
-
-
18744375998
-
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
-
Jeong JW, Bae MK, Ahn MY, Kim SH, Sohn TK, et al. 2002. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell 111:709-720.
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ahn, M.Y.3
Kim, S.H.4
Sohn, T.K.5
-
64
-
-
0035347260
-
Induction of HIF-1alpha in response to hypoxia is instantaneous
-
Jewell UR, Kvietikova I, Scheid A, Bauer C, Wenger RH, et al. 2001. Induction of HIF-1alpha in response to hypoxia is instantaneous. FASEB J 15:1312-1314.
-
(2001)
FASEB J
, vol.15
, pp. 1312-1314
-
-
Jewell, U.R.1
Kvietikova, I.2
Scheid, A.3
Bauer, C.4
Wenger, R.H.5
-
65
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxiainducible factor 1α-modulation of transcriptional activity by oxygen tension
-
Jiang B-H, Zheng JZ, Leung SW, Roe R, Semenza GL. 1997. Transactivation and inhibitory domains of hypoxiainducible factor 1α-modulation of transcriptional activity by oxygen tension. J Biol Chem 31:19253-19260.
-
(1997)
J Biol Chem
, vol.31
, pp. 19253-19260
-
-
Jiang, B.-H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
66
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin WG Jr. 2002. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2:673-682.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 673-682
-
-
Kaelin Jr., W.G.1
-
68
-
-
0029797225
-
Hypoxia/ischemia and the pH paradox
-
LaManna JC. 1996. Hypoxia/ischemia and the pH paradox. Adv Exp Med Biol 388:283-292.
-
(1996)
Adv Exp Med Biol
, vol.388
, pp. 283-292
-
-
La Manna, J.C.1
-
69
-
-
4644371659
-
Structural and functional adaptation to hypoxia in the rat brain
-
LaManna JC, Chavez JC, Pichiule P. 2004. Structural and functional adaptation to hypoxia in the rat brain. J Exp Biol 207:3163-3169.
-
(2004)
J Exp Biol
, vol.207
, pp. 3163-3169
-
-
La Manna, J.C.1
Chavez, J.C.2
Pichiule, P.3
-
70
-
-
0029904154
-
Decreased rat brain cytochrome oxidase activity after prolonged hypoxia
-
LaManna JC, Kutina-Nelson KL, Hritz MA, Huang Z, Wong-Riley MTT. 1996. Decreased rat brain cytochrome oxidase activity after prolonged hypoxia. Brain Res 720:1-6.
-
(1996)
Brain Res
, vol.720
, pp. 1-6
-
-
La Manna, J.C.1
Kutina-Nelson, K.L.2
Hritz, M.A.3
Huang, Z.4
Wong-Riley, M.T.T.5
-
71
-
-
0026636523
-
Brain adaptation to chronic hypobaric hypoxia in rats
-
LaManna JC, Vendel LM, Farrell RM. 1992. Brain adaptation to chronic hypobaric hypoxia in rats. J Appl Physiol 72:2238-2243.
-
(1992)
J Appl Physiol
, vol.72
, pp. 2238-2243
-
-
La Manna, J.C.1
Vendel, L.M.2
Farrell, R.M.3
-
72
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, et al. 2002. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16:1466-1471.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
-
73
-
-
0030833764
-
Adequacy of cerebral vascular remodeling following three weeks of hypobaric hypoxia. Examined by an integrated composite analytical model
-
Lauro KL, LaManna JC. 1997. Adequacy of cerebral vascular remodeling following three weeks of hypobaric hypoxia. Examined by an integrated composite analytical model. Adv Exp Med Biol 411:369-376.
-
(1997)
Adv Exp Med Biol
, vol.411
, pp. 369-376
-
-
Lauro, K.L.1
La Manna, J.C.2
-
74
-
-
0026675488
-
Hypoxia induces glucose transporter expression in endothelial cells
-
Loike JD, Cao L, Brett J, Ogawa S, Silverstein SC, et al. 1992. Hypoxia induces glucose transporter expression in endothelial cells. Am J Physiol 263:C326-C333.
-
(1992)
Am J Physiol
, vol.263
-
-
Loike, J.D.1
Cao, L.2
Brett, J.3
Ogawa, S.4
Silverstein, S.C.5
-
75
-
-
3042755032
-
Insulinlike growth factor I is required for vessel remodeling in the adult brain
-
Lopez-Lopez C, LeRoith D, Torres-Aleman I. 2004. Insulinlike growth factor I is required for vessel remodeling in the adult brain. Proc Natl Acad Sci USA 101:9833-9838.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 9833-9838
-
-
Lopez-Lopez, C.1
Le Roith, D.2
Torres-Aleman, I.3
-
76
-
-
0037189542
-
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
-
Lu H, Forbes RA, Verma A. 2002. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277:23111-23115.
-
(2002)
J Biol Chem
, vol.277
, pp. 23111-23115
-
-
Lu, H.1
Forbes, R.A.2
Verma, A.3
-
78
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. 2001. FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
79
-
-
12244289642
-
Pyruvate dehydrogenase complex: Metabolic link to ischemic brain injury and target of oxidative stress
-
Martin E, Rosenthal RE, Fiskum G. 2005. Pyruvate dehydrogenase complex: Metabolic link to ischemic brain injury and target of oxidative stress. J Neurosci Res 79:240-247.
-
(2005)
J Neurosci Res
, vol.79
, pp. 240-247
-
-
Martin, E.1
Rosenthal, R.E.2
Fiskum, G.3
-
80
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
-
Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. 2001. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J 20:5197-5206.
-
(2001)
EMBO J
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
81
-
-
0031018353
-
Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes
-
Masuda S, Chikuma M, Sasaki R. 1997. Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes. Brain Res 746:63-70.
-
(1997)
Brain Res
, vol.746
, pp. 63-70
-
-
Masuda, S.1
Chikuma, M.2
Sasaki, R.3
-
82
-
-
0346027211
-
Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and-independent pathways
-
Mateo J, Garcia-Lecea M, Cadenas S, Hernandez C, Moncada S. 2003. Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem J 376:537-544.
-
(2003)
Biochem J
, vol.376
, pp. 537-544
-
-
Mateo, J.1
Garcia-Lecea, M.2
Cadenas, S.3
Hernandez, C.4
Moncada, S.5
-
83
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, et al. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
-
85
-
-
0037386143
-
Intracellular localisation of human HIF-1 alpha hydroxylases: Implications for oxygen sensing
-
Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, et al. 2003. Intracellular localisation of human HIF-1 alpha hydroxylases: Implications for oxygen sensing. J Cell Sci 116:1319-1326.
-
(2003)
J Cell Sci
, vol.116
, pp. 1319-1326
-
-
Metzen, E.1
Berchner-Pfannschmidt, U.2
Stengel, P.3
Marxsen, J.H.4
Stolze, I.5
-
86
-
-
0037155247
-
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect
-
Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, et al. 2002. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2- kinase/fructose-2, 6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 277:6183-6187.
-
(2002)
J Biol Chem
, vol.277
, pp. 6183-6187
-
-
Minchenko, A.1
Leshchinsky, I.2
Opentanova, I.3
Sang, N.4
Srinivas, V.5
-
87
-
-
0021349488
-
Hypoxic coordinate regulation of mitochondrial enzymes in mammalian cells
-
Murphy BJ, Robin ED, Tapper DP, Wong RJ, Clayton DA. 1984. Hypoxic coordinate regulation of mitochondrial enzymes in mammalian cells. Science 223:707-709.
-
(1984)
Science
, vol.223
, pp. 707-709
-
-
Murphy, B.J.1
Robin, E.D.2
Tapper, D.P.3
Wong, R.J.4
Clayton, D.A.5
-
88
-
-
0021089984
-
Metabolic acids and [H+] regulation in brain tissue during acclimatization to chronic hypoxia
-
Musch TI, Dempsey JA, Smith CA, Mitchell GS, Bateman NT. 1983. Metabolic acids and [H+] regulation in brain tissue during acclimatization to chronic hypoxia. J Appl Physiol 55:1486-1495.
-
(1983)
J Appl Physiol
, vol.55
, pp. 1486-1495
-
-
Musch, T.I.1
Dempsey, J.A.2
Smith, C.A.3
Mitchell, G.S.4
Bateman, N.T.5
-
89
-
-
2942731503
-
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
-
Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, et al. 2004. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 117:941-952.
-
(2004)
Cell
, vol.117
, pp. 941-952
-
-
Nakayama, K.1
Frew, I.J.2
Hagensen, M.3
Skals, M.4
Habelhah, H.5
-
90
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, et al. 2000. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423-427.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
-
91
-
-
0034698178
-
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
-
Osthus RC, Shim H, Kim S, Li Q, Reddy R, et al. 2000. Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 275:21797-21800.
-
(2000)
J Biol Chem
, vol.275
, pp. 21797-21800
-
-
Osthus, R.C.1
Shim, H.2
Kim, S.3
Li, Q.4
Reddy, R.5
-
92
-
-
0015505764
-
Barbiturate-induced glycogen accumulation in brain. An electron microscopic study
-
Phelps CH. 1972. Barbiturate-induced glycogen accumulation in brain. An electron microscopic study. Brain Res 39:225-234.
-
(1972)
Brain Res
, vol.39
, pp. 225-234
-
-
Phelps, C.H.1
-
93
-
-
12144289492
-
Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: Implications for Alzheimer's disease
-
Planel E, Miyasaka T, Launey T, Chui DH, Tanemura K, et al. 2004. Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: Implications for Alzheimer's disease. J Neurosci 24:2401-2411.
-
(2004)
J Neurosci
, vol.24
, pp. 2401-2411
-
-
Planel, E.1
Miyasaka, T.2
Launey, T.3
Chui, D.H.4
Tanemura, K.5
-
94
-
-
0030937718
-
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. 1997. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem 272:11205-11214.
-
(1997)
J Biol Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
95
-
-
0015251175
-
Bioenergetics and the problem of tumor growth
-
Racker E. 1972. Bioenergetics and the problem of tumor growth. Am Sci 60:56-63.
-
(1972)
Am Sci
, vol.60
, pp. 56-63
-
-
Racker, E.1
-
96
-
-
0019883373
-
Warburg effect revisited: Merger of biochemistry and molecular biology
-
Racker E, Spector M. 1981. Warburg effect revisited: Merger of biochemistry and molecular biology. Science 213:303-307.
-
(1981)
Science
, vol.213
, pp. 303-307
-
-
Racker, E.1
Spector, M.2
-
97
-
-
10744226140
-
Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1 alpha and HIF-2 alpha in a primary neuronal model of hypoxia
-
Ralph GS, Parham S, Lee SR, Beard GL, Craigon MH, et al. 2004. Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1 alpha and HIF-2 alpha in a primary neuronal model of hypoxia. J Cereb Blood Flow Metab 24:245-258.
-
(2004)
J Cereb Blood Flow Metab
, vol.24
, pp. 245-258
-
-
Ralph, G.S.1
Parham, S.2
Lee, S.R.3
Beard, G.L.4
Craigon, M.H.5
-
98
-
-
0034282388
-
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
-
Richard DE, Berra E, Pouyssegur J. 2000. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 275:26765-26771.
-
(2000)
J Biol Chem
, vol.275
, pp. 26765-26771
-
-
Richard, D.E.1
Berra, E.2
Pouyssegur, J.3
-
100
-
-
0034703017
-
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity
-
Rivard A, Berthou-Soulie L, Principe N, Kearney M, Curry C, et al. 2000. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J Biol Chem 275:29643-29647.
-
(2000)
J Biol Chem
, vol.275
, pp. 29643-29647
-
-
Rivard, A.1
Berthou-Soulie, L.2
Principe, N.3
Kearney, M.4
Curry, C.5
-
101
-
-
0021345887
-
Coordinate regulation of glycolysis by hypoxia in mammalian cells
-
Robin ED, Murphy BJ, Theodore J. 1984. Coordinate regulation of glycolysis by hypoxia in mammalian cells. J Cell Physiol 118:287-290.
-
(1984)
J Cell Physiol
, vol.118
, pp. 287-290
-
-
Robin, E.D.1
Murphy, B.J.2
Theodore, J.3
-
102
-
-
0030961006
-
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions-its stabilization by hypoxia depends on redox-induced changes
-
Salceda S, Caro J. 1997. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions-its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-22647.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
103
-
-
0032877460
-
Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors
-
Salnikow K, An WG, Melillo G, Blagosklonny MV, Costa M. 1999. Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors. Carcinogenesis 20:1819-1823.
-
(1999)
Carcinogenesis
, vol.20
, pp. 1819-1823
-
-
Salnikow, K.1
An, W.G.2
Melillo, G.3
Blagosklonny, M.V.4
Costa, M.5
-
104
-
-
0033984256
-
Carcinogenic nickel induces genes involved with hypoxic stress
-
Salnikow K, Blagosklonny MV, Ryan H, Johnson R, Costa M. 2000. Carcinogenic nickel induces genes involved with hypoxic stress. Cancer Res 60:38-41.
-
(2000)
Cancer Res
, vol.60
, pp. 38-41
-
-
Salnikow, K.1
Blagosklonny, M.V.2
Ryan, H.3
Johnson, R.4
Costa, M.5
-
105
-
-
0035027828
-
Transcription Factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells
-
Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, et al. 2001. Transcription Factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol Cell Biol 21:3436-3444.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
Wouters, B.G.4
Knapp, M.5
-
106
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
-
Selak MA, Armour SM, Mackenzie ED, Boulahbel H, Watson DG, et al. 2005. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 7:77-85.
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
Mackenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
-
107
-
-
0032190614
-
Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
-
Semenza GL. 1998. Hypoxia-inducible factor 1: Master regulator of O2 homeostasis. Curr Opin Genet Dev 8:588-594.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 588-594
-
-
Semenza, G.L.1
-
108
-
-
0033233243
-
2 homeostasis by hypoxia-inducible factor 1
-
2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551-578.
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
109
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza GL. 2000a. HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88:1474-1480.
-
(2000)
J Appl Physiol
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
110
-
-
0034021690
-
Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
-
Semenza GL. 2000b. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 35:71-103.
-
(2000)
Crit Rev Biochem Mol Biol
, vol.35
, pp. 71-103
-
-
Semenza, G.L.1
-
111
-
-
0037015019
-
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP
-
Semenza GL. 2002. Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP. Proc Natl Acad Sci USA 99:11570-11572.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11570-11572
-
-
Semenza, G.L.1
-
112
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. 2003. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
113
-
-
8044253996
-
Structural and functional analysis of hypoxia-inducible factor 1
-
Semenza GL, Agani F, Booth G, Forsythe J, Iyer N, et al. 1997. Structural and functional analysis of hypoxia-inducible factor 1. Kidney Int 51:553-555.
-
(1997)
Kidney Int
, vol.51
, pp. 553-555
-
-
Semenza, G.L.1
Agani, F.2
Booth, G.3
Forsythe, J.4
Iyer, N.5
-
114
-
-
0034464872
-
Hypoxia, HIF-1, and the pathophysiology of common human diseases
-
Semenza GL, Agani F, Feldser D, Iyer N, Kotch L, et al. 2000. Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 475:123-130.
-
(2000)
Adv Exp Med Biol
, vol.475
, pp. 123-130
-
-
Semenza, G.L.1
Agani, F.2
Feldser, D.3
Iyer, N.4
Kotch, L.5
-
115
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang H-M, Wang GL. 1994. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269:23757-23763.
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.-M.3
Wang, G.L.4
-
117
-
-
2642555563
-
HIF1 and oxygen sensing in the brain
-
Sharp FR, Bernaudin M. 2004. HIF1 and oxygen sensing in the brain. Nat Rev Neurosci 5:437-448.
-
(2004)
Nat Rev Neurosci
, vol.5
, pp. 437-448
-
-
Sharp, F.R.1
Bernaudin, M.2
-
118
-
-
2942737069
-
Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia
-
Simon MC. 2004. Siah proteins, HIF prolyl hydroxylases, and the physiological response to hypoxia. Cell 117:851-853.
-
(2004)
Cell
, vol.117
, pp. 851-853
-
-
Simon, M.C.1
-
119
-
-
0038644221
-
The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide
-
Soucek T, Cumming R, Dargusch R, Maher P, Schubert D. 2003. The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron 39:43-56.
-
(2003)
Neuron
, vol.39
, pp. 43-56
-
-
Soucek, T.1
Cumming, R.2
Dargusch, R.3
Maher, P.4
Schubert, D.5
-
121
-
-
0035159670
-
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
-
Stroka DM, Burkhardt T, Desbaillets I, Wenger RH, Neil DA, et al. 2001. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J 15:2445-2453.
-
(2001)
FASEB J
, vol.15
, pp. 2445-2453
-
-
Stroka, D.M.1
Burkhardt, T.2
Desbaillets, I.3
Wenger, R.H.4
Neil, D.A.5
-
122
-
-
12244257553
-
Understanding the tumor metabolic phenotype in the genomic era
-
Stubbs M, Bashford CL, Griffiths JR. 2003. Understanding the tumor metabolic phenotype in the genomic era. Curr Mol Med 3:49-59.
-
(2003)
Curr Mol Med
, vol.3
, pp. 49-59
-
-
Stubbs, M.1
Bashford, C.L.2
Griffiths, J.R.3
-
123
-
-
0027058922
-
Physiologic coupling of glial glycogen metabolism to neuronal activity in brain
-
Swanson RA. 1992. Physiologic coupling of glial glycogen metabolism to neuronal activity in brain. Can J Physiol Pharmacol 70:S138-S144.
-
(1992)
Can J Physiol Pharmacol
, vol.70
-
-
Swanson, R.A.1
-
124
-
-
0026541812
-
Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography
-
Swanson RA, Morton MM, Sagar SM, Sharp FR. 1992. Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography. Neuroscience 51:451-461.
-
(1992)
Neuroscience
, vol.51
, pp. 451-461
-
-
Swanson, R.A.1
Morton, M.M.2
Sagar, S.M.3
Sharp, F.R.4
-
125
-
-
0033870281
-
The expression and distribution of the hypoxiainducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
-
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, et al. 2000. The expression and distribution of the hypoxiainducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157:411-421.
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
-
126
-
-
0035812318
-
Characterization and comparative analysis of the EGLN gene family
-
Taylor MS. 2001. Characterization and comparative analysis of the EGLN gene family. Gene 275:125-132.
-
(2001)
Gene
, vol.275
, pp. 125-132
-
-
Taylor, M.S.1
-
128
-
-
0141669198
-
Defective brain development in mice lacking the Hif-1alpha gene in neural cells
-
Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, et al. 2003. Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol 23:6739-6749.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6739-6749
-
-
Tomita, S.1
Ueno, M.2
Sakamoto, M.3
Kitahama, Y.4
Ueki, M.5
-
129
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van OE. 2002. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 277:27975-27981.
-
(2002)
J Biol Chem
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van, O.E.5
-
131
-
-
0029051439
-
Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. 1995. Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92:5510-5514.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
132
-
-
0027210562
-
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
-
Wang GL, Semenza GL. 1993. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90:4304-4308.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 4304-4308
-
-
Wang, G.L.1
Semenza, G.L.2
-
133
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL, Semenza GL. 1995. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
134
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. 1956. On the origin of cancer cells. Science 123:309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
135
-
-
0038380470
-
Activation of the hypoxia-inducible factorpathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors
-
Warnecke C, Griethe W, Weidemann A, Jurgensen JS, Willam C, et al. 2003. Activation of the hypoxia-inducible factorpathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. FASEB J 17:1186-1188.
-
(2003)
FASEB J
, vol.17
, pp. 1186-1188
-
-
Warnecke, C.1
Griethe, W.2
Weidemann, A.3
Jurgensen, J.S.4
Willam, C.5
-
136
-
-
0042761742
-
Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia
-
Webster KA. 2003. Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia. J Exp Biol 206:2911-2922.
-
(2003)
J Exp Biol
, vol.206
, pp. 2911-2922
-
-
Webster, K.A.1
-
137
-
-
0001452814
-
Regulation of tissue-specific glycolytic isozyme genes: Coordinate regulation by oxygen availability in skeletal muscle cells
-
Webster KA, Murphy BJ. 1988. Regulation of tissue-specific glycolytic isozyme genes: Coordinate regulation by oxygen availability in skeletal muscle cells. Can J Zool 66:1046-4058.
-
(1988)
Can J Zool
, vol.66
, pp. 1046-4058
-
-
Webster, K.A.1
Murphy, B.J.2
-
138
-
-
0037315337
-
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs
-
Wiesener MS, Jurgensen JS, Rosenberger C, Scholze CK, Horstrup JH, et al. 2003. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J 17:271-273.
-
(2003)
FASEB J
, vol.17
, pp. 271-273
-
-
Wiesener, M.S.1
Jurgensen, J.S.2
Rosenberger, C.3
Scholze, C.K.4
Horstrup, J.H.5
-
139
-
-
0024561501
-
Cytochrome oxidase: An endogenous metabolic marker for neuronal activity
-
Wong-Riley MTT. 1989. Cytochrome oxidase: An endogenous metabolic marker for neuronal activity. Trends Neurosci 12:94-101.
-
(1989)
Trends Neurosci
, vol.12
, pp. 94-101
-
-
Wong-Riley, M.T.T.1
-
140
-
-
12544256565
-
Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
-
Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, et al. 2005. Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 65:613-621.
-
(2005)
Cancer Res
, vol.65
, pp. 613-621
-
-
Xu, R.H.1
Pelicano, H.2
Zhou, Y.3
Carew, J.S.4
Feng, L.5
-
141
-
-
0035834598
-
Identification of genes differentially induced by hypoxia in pancreatic cancer cells
-
Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, et al. 2001. Identification of genes differentially induced by hypoxia in pancreatic cancer cells. Biochem Biophys Res Commun 288:882-886.
-
(2001)
Biochem Biophys Res Commun
, vol.288
, pp. 882-886
-
-
Yoon, D.Y.1
Buchler, P.2
Saarikoski, S.T.3
Hines, O.J.4
Reber, H.A.5
-
142
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1a
-
Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, et al. 1999. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1a. J Clin Invest 103:691-696.
-
(1999)
J Clin Invest
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
Huso, D.L.4
Sun, X.5
-
143
-
-
0037844847
-
Cobalt inhibits the interaction between hypoxia-inducible factoralpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha
-
Yuan Y, Hilliard G, Ferguson T, Millhorn DE. 2003. Cobalt inhibits the interaction between hypoxia-inducible factoralpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J Biol Chem 278:15911-15916.
-
(2003)
J Biol Chem
, vol.278
, pp. 15911-15916
-
-
Yuan, Y.1
Hilliard, G.2
Ferguson, T.3
Millhorn, D.E.4
-
144
-
-
0032169214
-
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1 alpha/ARNT
-
Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, et al. 1998. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1 alpha/ARNT. EMBO J 17:5085-5094.
-
(1998)
EMBO J
, vol.17
, pp. 5085-5094
-
-
Zelzer, E.1
Levy, Y.2
Kahana, C.3
Shilo, B.Z.4
Rubinstein, M.5
-
145
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, et al. 2000. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res 60:1541-1545.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
-
146
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, et al. 1999. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
-
147
-
-
0347694776
-
Cancer metabolism: Facts, fantasy, and fiction
-
Zu XL, Guppy M. 2004. Cancer metabolism: Facts, fantasy, and fiction. Biochem Biophys Res Commun 313:459-465.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 459-465
-
-
Zu, X.L.1
Guppy, M.2
|