Evaluation of the effects of the parameters involved in the purification of clavulanic acid from fermentation broth by aqueous two-phase systems

Bioprocess and Biosystems Engineering

Volumn 32, Issue 5, 2009, Pages 625-632

  Silva, C S ^a   Bovarotti, E ^a   Rodrigues, M I ^b   Hokka, C O ^a   Barboza, Marlei ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Aqueous two phase systems, polyethylene glycol (PEG); Central composite rotational design (CCRD); Clavulanic acid; Fermentation broth; Purification

Indexed keywords

AQUEOUS TWO PHASE SYSTEM; AQUEOUS TWO-PHASE SYSTEMS, POLYETHYLENE GLYCOL (PEG); CENTRAL COMPOSITE ROTATIONAL DESIGN (CCRD); CLAVULANIC ACID; DISTRIBUTION COEFFICIENT; EXPERIMENTAL DESIGN; FERMENTATION BROTH; FERMENTATION BROTHS; ISO-ELECTRIC POINTS; LOW MOLECULAR MASS; OPTIMAL CONDITIONS; PHASE VOLUME; PHASE VOLUME RATIO; PURIFICATION FACTORS; RESPONSE SURFACE METHODOLOGY; STREPTOMYCES CLAVULIGERUS; SUBMERGED CULTIVATION; TIE-LINE;

ACIDS; CARBOXYLIC ACIDS; FERMENTATION; MOLECULAR MASS; OPTIMIZATION; POLYETHYLENE OXIDES; PURIFICATION; THERMOPLASTICS;

POLYETHYLENE GLYCOLS;

CLAVULANIC ACID; MACROGOL; PHOSPHATE;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DRUG ISOLATION; DRUG PURIFICATION; EXPERIMENTAL DESIGN; FERMENTATION; ISOELECTRIC POINT; MOLECULAR WEIGHT; NONHUMAN; PH; PRIORITY JOURNAL; RESPONSE SURFACE METHOD; STREPTOMYCES CLAVULIGERUS; TEMPERATURE;

BIOREACTORS; CLAVULANIC ACID; COMPUTER SIMULATION; FERMENTATION; MODELS, BIOLOGICAL; PHASE TRANSITION; STREPTOMYCES; WATER;

STREPTOMYCES CLAVULIGERUS;

EID: 68349146304     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-008-0285-6     Document Type: Article

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