Mechanistic study on growth suppression and apoptosis induction by targeting Hepatoma-derived growth factor in human Hepatocellular Carcinoma HepG2 cells

Cellular Physiology and Biochemistry

Volumn 24, Issue 3-4, 2009, Pages 253-262

  Tsang, Tsun Yee ^a   Tang, Wan Yee ^a,b   Tsang, Wing Pui ^a   Co, Ngai Na ^a   Kong, Siu Kai ^a   Kwok, Tim Tak ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Anchorage independent growth; Apoptosis; Bad; Fas; HDGF; NF B I B

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; FAS ANTIGEN; HEPATOMA DERIVED GROWTH FACTOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; LUCIFERASE; PROTEIN BAD; SMALL INTERFERING RNA;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL SURVIVAL; DOWN REGULATION; GENE ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING;

EID: 68349144634     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000233250     Document Type: Article

References (26)

1. Nakamura H, Kambe H, Egawa T, Kimura Y, Ito H, Hayashi E, Yamamoto H, Sato J, Kishimoto S: Partial purification and characterization of human hepatomaderived growth factor. Clin Chim Acta 1989;183:273-284.
2. Nakamura H, Izumoto Y, Kambe H, Kuroda T, Mori T, Kawamura K, Yamamoto H, Kishimoto T: Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein. J Biol Chem 1994;269:25143-25149.
3. Everett AD, Lobe DR, Matsumura ME, Nakamura H, McNamara CA: Hepatomaderived growth factor stimulates smooth muscle cell growth and is expressed in vascular development. J Clin Invest 2000;105:567-575.
4. Oliver JA, Al-Awqati Q: An endothelial growth factor involved in rat renal development. J Clin Invest 1998;102:1208-1219.
5. Hu TH, Huang CC, Liu LF, Lin PR, Liu SY, Chang HW, Changchien CS, Lee CM, Chuang JH, Tai MH: Expression of hepatoma-derived growth factor in hepatocellular carcinoma. Cancer 2003;98:1444-1456.
6. Yoshida K, Nakamura H, Okuda Y, Enomoto H, Kishima Y, Uyama H, Ito H, Hirasawa T, Inagaki S, Kawase I: Expression of hepatoma-derived growth factor in hepatocarcinogenesis. J Gastroenterol Hepatol 2003;18:1293-1301.
7. Huang JS, Chao CC, Su TL, Yeh SH, Chen DS, Chen CT, Chen PJ, Jou YS: Diverse cellular transformation capability of overexpressed genes in human hepatocellular carcinoma. Biochem Biophys Res Commun 2004;315:950-958.
8. Yoshida K, Tomita Y, Okuda Y, Yamamoto S, Enomoto H, Uyama H, Ito H, Hoshida Y, Aozasa K, Nagano H, Sakon M, Kawase I, Monden M, Nakamura H: Hepatoma-derived growth factor is a novel prognostic factor for hepatocellular carcinoma. Ann Surg Oncol 2006;13:159-167.
9. Yamamoto S, Tomita Y, Hoshida Y, Takiguchi S, Fujiwara Y, Yasuda T, Doki Y, Yoshida K, Aozasa K, Nakamura H, Monden M: Expression of hepatomaderived growth factor is correlated with lymph node metastasis and prognosis of gastric carcinoma. Clin Cancer Res 2006;12:117-122.
10. Chang KC, Tai MH, Lin JW, Wang CC, Huang CC, Hung CH, Chen CH, Lu SN, Lee CM, Changchien CS, Hu TH: Hepatoma-derived growth factor is a novel prognostic factor for gastrointestinal stromal tumors. Int J Cancer 2007;121:1059-1065.
11. Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y, Shivdasani RA: Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development 2005;132:415-427.
12. Ren H, Tang X, Lee JJ, Feng L, Everett AD, Hong WK, Khuri FR, Mao L: Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-smallcell lung cancer. J Clin Oncol 2004;22:3230-3237.
13. Uyama H, Tomita Y, Nakamura H, Nakamori S, Zhang B, Hoshida Y, Enomoto H, Okuda Y, Sakon M, Aozasa K, Kawase I, Hayashi N, Monden M: Hepatoma-derived growth factor is a novel prognostic factor for patients with pancreatic cancer. Clin Cancer Res 2006;12:6043-6048.
14. Bernard K, Litman E, Fitzpatrick JL, Shellman YG, Argast G, Polvinen K, Everett AD, Fukasawa K, Norris DA, Ahn NG, Resing KA: Functional proteomic analysis of melanoma progression. Cancer Res 2003;63:6716-6725.
15. Tsang TY, Tang WY, Tsang WP, Co NN, Kong SK, Kwok TT: Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells. Apoptosis 2008;13:1135-1147.
16. Khosravi-Far R, Esposti MD: Death receptor signals to mitochondria. Cancer Biol Ther 2004;3:1051-1057.
17. Debatin KM, Krammer PH: Death receptors in chemotherapy and cancer. Oncogene 2004;23:2950-2966.
18. Walczak H, Sprick MR: Biochemistry and function of the DISC. Trends Biochem Sci 2001;26:452-453.
19. Donepudi M, Mac Sweeney A, Briand C, Grutter MG: Insights into the regulatory mechanism for caspase-8 activation. Mol Cell 2003;11:543-549.
20. Chan H, Bartos DP, Owen-Schaub LB: Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment. Mol Cell Biol 1999;19:2098-2108.
21. Whiteside ST, Israel A: I kappa B proteins: structure, function and regulation. Semin Cancer Biol 1997;8:75-82.
22. Karin M, Ben-Neriah Y: Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 2000;18:621-663.
23. Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT: Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. Oncogene 1999;18:3063-3070.
24. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, Korsmeyer SJ: tBID, a membranetargeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 2000;14:2060-2071.
25. Maeng YS, Min JK, Kim JH, Yamagishi A, Mochizuki N, Kwon JY, Park YW, Kim YM, Kwon YG: ERK is an antiinflammatory signal that suppresses expression of NF-kappaB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells. Cell Signal 2006;18:994-1005.
26. Nameki N, Tochio N, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Fujikura Y, Saito M, Ikari M, Watanabe M, Terada T, Shirouzu M, Yoshida M, Hirota H, Tanaka A, Hayashizaki Y, Guntert P, Kigawa T, Yokoyama S: Solution structure of the PWWP domain of the hepatoma-derived growth factor family. Protein Sci 2005;14:756-764.