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Volumn 19, Issue 17, 2009, Pages 5124-5127

Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptors

Author keywords

Neuropeptide Y; Neuropeptide Y Y1; Positron emission tomography

Indexed keywords

FUNCTIONAL GROUP; NEUROPEPTIDE Y Y1 RECEPTOR; NEUROPEPTIDE Y1 RECEPTOR; PYRIDINE 2,4 DIAMINE DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

EID: 68349141368     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.030     Document Type: Article
Times cited : (10)

References (29)
  • 23
    • 68349152057 scopus 로고    scopus 로고
    • For the preparation of 4,5,6,7-tetrahydrobenzoxazole-2-thiol for compound 2k, see: Bobosik, V.; Piklerova, A.; Martvon, A. Collect. Czech. Chem. Commun. 1983, 48, 3421. 4,5-Dimethyloxazole-2-thiol for 2a-i and 5-ethyl-4-methyloxazole-2-thiol for 2j were prepared in a similar manner. 4,5-Dimethylthiazole-2-thiol for 2l is commercially available (Wako Pure Chemical Industries, Ltd).
    • For the preparation of 4,5,6,7-tetrahydrobenzoxazole-2-thiol for compound 2k, see: Bobosik, V.; Piklerova, A.; Martvon, A. Collect. Czech. Chem. Commun. 1983, 48, 3421. 4,5-Dimethyloxazole-2-thiol for 2a-i and 5-ethyl-4-methyloxazole-2-thiol for 2j were prepared in a similar manner. 4,5-Dimethylthiazole-2-thiol for 2l is commercially available (Wako Pure Chemical Industries, Ltd).
  • 24
    • 68349140913 scopus 로고    scopus 로고
    • note
    • 125I]PYY (25 pM) at 25 °C for 120 min. Following three washes, the membrane-bound radioactivity was measured using a TopCount™ microplate scintillation counter (Packard, Meriden, CT). Non-specific binding was determined in the presence of an excess amount of cold porcine PYY (1 μM).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.