Short-term growth hormone treatment and microcirculation: Effects in patients with chronic kidney disease

Microvascular Research

Volumn 78, Issue 2, 2009, Pages 246-252

  Nissel, Richard ^a   Fischer, Dagmar Christiane ^a   Puhlmann, Andreas ^a   Holdt Lehmann, Birgit ^b   Mitzner, Andrea ^b   Petzsch, Michael ^b   Körber, Thomas ^b   Tieß, Michael ^c   Schmidt, Reinhard ^b   Haffner, Dieter ^a  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c Dialysis Group North   (Germany)

Author keywords

Cardiac index; Chronic kidney disease; Endothelial dysfunction; Growth hormone treatment; Microcirculation; Nailfold capillaroscopy; Venous occlusion plethysmography

Indexed keywords

HUMAN GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ARTICLE; CAPILLAROSCOPY; CAPILLARY FLOW; CARDIOVASCULAR DISEASE; CARDIOVASCULAR EFFECT; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; ECHOCARDIOGRAPHY; ENDOTHELIAL DYSFUNCTION; ERYTHROCYTE KINETICS; EVENING DOSAGE; FEMALE; HEART INDEX; HEART OUTPUT; HEART RATE; HORMONAL THERAPY; HUMAN; LEG BLOOD FLOW; MALE; MICROCIRCULATION; MORTALITY; PILOT STUDY; PLETHYSMOGRAPH; PRIORITY JOURNAL; SHORT COURSE THERAPY; VASCULAR RESISTANCE;

ADULT; BODY MASS INDEX; CASE-CONTROL STUDIES; ECHOCARDIOGRAPHY; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; KIDNEY FAILURE, CHRONIC; MALE; MICROCIRCULATION; MICROSCOPY, VIDEO; MIDDLE AGED; PILOT PROJECTS; PLETHYSMOGRAPHY; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; TREATMENT OUTCOME;

EID: 68349135428     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2009.05.006     Document Type: Article

References (50)

1. Bar R.S., et al. IGF receptors in myocardial capillary endothelium: potential regulation of IGF-I transport to cardiac muscle. Biochem. Biophys. Res. Commun. 152 (1988) 93-98
2. Baylis C., and Vallance P. Measurement of nitrite and nitrate levels in plasma and urine-what does this measure tell us about the activity of the endogenous nitric oxide system?. Curr. Opin. Nephrol. Hypertens. 7 (1998) 59-62
3. Briese S., et al. Arterial and cardiac disease in young adults with childhood-onset end-stage renal disease-impact of calcium and vitamin D therapy. Nephrol. Dial. Transplant. 21 (2006) 1906-1914
4. Brown J.H., et al. Comparative mortality from cardiovascular disease in patients with chronic renal failure. Nephrol. Dial. Transplant. 9 (1994) 1136-1142
5. Cannata-Andia J.B., et al. Vascular calcifications: pathogenesis, management, and impact on clinical outcomes. J. Am. Soc. Nephrol. 17 (2006) S267-273
6. Capaldo B., et al. Abnormal vascular reactivity in growth hormone deficiency. Circulation 103 (2001) 520-524
7. Cittadini A., et al. Supraphysiological doses of GH induce rapid changes in cardiac morphology and function. J. Clin. Endocrinol. Metab. 87 (2002) 1654-1659
8. Cupisti A., et al. Responses of the skin microcirculation to acetylcholine and to sodium nitroprusside in chronic uremic patients. Int. J. Clin. Lab. Res. 30 (2000) 157-162
9. Cupisti A., et al. Responses of the skin microcirculation to acetylcholine in patients with essential hypertension and in normotensive patients with chronic renal failure. Nephron 85 (2000) 114-119
10. Farkas K., et al. Impairment of skin microvascular reactivity in hypertension and uraemia. Nephrol. Dial. Transplant. 20 (2005) 1821-1827
11. Feldt-Rasmussen B., et al. Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk. J. Am. Soc. Nephrol. 18 (2007) 2161-2171
12. Ganau A., et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J. Am. Coll. Cardiol. 19 (1992) 1550-1558
13. Gasser P., and Bühler F.R. Nailfold microcirculation in normotensive and essential hypertensive subjects, as assessed by video-microscopy. J. Hypertens. 10 (1992) 83-86
14. Hana V., et al. Reduced microvascular perfusion and reactivity in adult GH deficient patients is restored by GH replacement. Eur. J. Endocrinol. 147 (2002) 333-337
15. Holdt B., et al. Comparative evaluation of two newly developed devices for capillary viscometry. Clin. Hemorheol. Microcirc. 33 (2005) 379-387
16. Irving R.J., et al. Microvascular correlates of blood pressure, plasma glucose, and insulin resistance in health. Cardiovasc. Res. 53 (2002) 271-276
17. Ito H., et al. Time course of functional improvement in stunned myocardium in risk area in patients with reperfused anterior infarction. Circulation 87 (1993) 355-362
18. Jung F., et al. Primary cutaneous microangiopathy in heart recipients. Microvasc. Res. 62 (2001) 154-163
19. Köhler R., et al. Impaired EDHF-mediated vasodilation and function of endothelial Ca-activated K channels in uremic rats. Kidney Int. 67 (2005) 2280-2287
20. Kruger A., et al. Laser Doppler flowmetry detection of endothelial dysfunction in end-stage renal disease patients: correlation with cardiovascular risk. Kidney Int. 70 (2006) 157-164
21. Lanes R., et al. Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue, and left ventricular mass and function in growth hormone-deficient adolescents: apparent effects of growth hormone treatment on these parameters. J. Clin. Endocrinol. Metab. 90 (2005) 3978-3982
22. Levey A.S., et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann. Intern. Med. 130 (1999) 461-470
23. Li G., et al. Growth hormone exerts acute vascular effects independent of systemic or muscle insulin-like growth factor I. J. Clin. Endocrinol. Metab. 93 (2008) 1379-1385
24. London G.M., et al. Impairment of arterial function in chronic renal disease: prognostic impact and therapeutic approach. Nephrol. Dial. Transplant. 17 Suppl. 11 (2002) 13-15
25. London G.M., et al. Forearm reactive hyperemia and mortality in end-stage renal disease. Kidney Int. 65 (2004) 700-704
26. Mahesh S., and Kaskel F. Growth hormone axis in chronic kidney disease. Pediatr. Nephrol. 23 (2008) 41-48
27. Møller N., et al. Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man. Diabetologia 32 (1989) 105-110
28. Morimoto L.M., et al. Variation in plasma insulin-like growth factor-1 and insulin-like growth factor binding protein-3: genetic factors. Cancer Epidemiol. Biomark. Prev. 14 (2005) 1394-1401
29. Napoli R., et al. Acute effects of growth hormone on vascular function in human subjects. J. Clin. Endocrinol. Metab. 88 (2003) 2817-2820
30. Oltman C.L., et al. Mechanism of coronary vasodilation to insulin and insulin-like growth factor I is dependent on vessel size. Am. J. Physiol. Endocrinol. Metab. 279 (2000) E176-181
31. Oomen P.H., et al. Reduced capillary permeability and capillary density in the skin of GH-deficient adults: improvement after 12 months GH replacement. Clin. Endocrinol. (Oxf) 56 (2002) 519-524
32. Passauer J., et al. Evidence in vivo showing increase of baseline nitric oxide generation and impairment of endothelium-dependent vasodilation in normotensive patients on chronic hemodialysis. J. Am. Soc. Nephrol. 11 (2000) 1726-1734
33. Passauer J., et al. Nitric oxide in chronic renal failure. Kidney Int. 67 (2005) 1665-1667
34. Passauer J., et al. Reduced agonist-induced endothelium-dependent vasodilation in uremia is attributable to an impairment of vascular nitric oxide. J. Am. Soc. Nephrol. 16 (2005) 959-965
35. Pignoli P., et al. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 74 (1986) 1399-1406
36. Rabkin R., et al. Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling. Pediatr. Nephrol. 20 (2005) 313-318
37. Rossi M., et al. Blunted post-ischemic increase of the endothelial skin blood flowmotion component as early sign of endothelial dysfunction in chronic kidney disease patients. Microvasc. Res. 75 (2008) 315-322
38. Sahn D.J., et al. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 58 (1978) 1072-1083
39. Schmidt R.J., and Baylis C. Total nitric oxide production is low in patients with chronic renal disease. Kidney Int. 58 (2000) 1261-1266
40. Schumann L., et al. Microcirculation of the fingernail fold in CAPD patients: preliminary observations. Perit. Dial. Int. 16 (1996) 412-416
41. Shamim-Uzzaman Q.A., et al. Altered cutaneous microvascular responses to reactive hyperaemia in coronary artery disease: a comparative study with conduit vessel responses. Clin. Sci. (Lond) 103 (2002) 267-273
42. Sigrist M.K., and McIntyre C.W. Vascular calcification is associated with impaired microcirculatory function in chronic haemodialysis patients. Nephron, Clin. Pract. 108 (2008) c121-c126
43. Thum T., and Bauersachs J. Growth hormone regulates vascular function-what we know from bench and bedside. Eur. J. Clin. Pharmacol. 62 Suppl. 13 (2006) 29-32
44. Thum T., et al. Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I. J. Clin. Endocrinol. Metab. 92 (2007) 4172-4179
45. Turner J.D., et al. Induction of mRNA for IGF-I and -II during growth hormone-stimulated muscle hypertrophy. Am. J. Physiol. 255 (1988) E513-517
46. Twickler T.B., et al. Growth hormone (GH) treatment decreases postprandial remnant-like particle cholesterol concentration and improves endothelial function in adult-onset GH deficiency. J. Clin. Endocrinol. Metab. 85 (2000) 4683-4689
47. van Guldener C., et al. Homocysteine and asymmetric dimethylarginine (ADMA): biochemically linked but differently related to vascular disease in chronic kidney disease. Clin. Chem. Lab. Med. 45 (2007) 1683-1687
48. Wu H.Y., et al. Endothelial-dependent vascular effects of insulin and insulin-like growth factor I in the perfused rat mesenteric artery and aortic ring. Diabetes 43 (1994) 1027-1032
49. Zheng Z., et al. Cardiac resistance to growth hormone in uremia. Kidney Int. 67 (2005) 858-866
50. Zoccali C., et al. Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients. Kidney Int. 62 (2002) 339-345