It is premature to recommend low-dose intravenous proton pump inhibition after endoscopic hemostasis in patients with bleeding ulcers

American Journal of Gastroenterology

Volumn 104, Issue 8, 2009, Pages 2120-2121

  Barkun, Alan N ^c   Kuipers, Ernst J ^a   Sung, Joseph Jy ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR;

CONTINUOUS INFUSION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; HEMOSTASIS; HUMAN; LETTER; LOW DRUG DOSE; MORTALITY; PEPTIC ULCER BLEEDING; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; SENSITIVITY ANALYSIS;

EID: 68349127153     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2009.210     Document Type: Letter

References (5)

1. Andriulli A, Loperfido S, Focareta R et al. High-versus low-dose proton pump inhibitors after endoscopic hemostasis in patients with peptic ulcer bleeding: a multicenter, randomized study. Am J Gastroenterol 2008;103:3011-8.
2. Barkun AN, Bardou M, Marshall JK, The Nonvariceal Upper GI Bleeding Consensus Conference Group. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Int Med 2003;139:843-57.
3. Gralnek IM, Barkun AN, Bardou M. Management of acute bleeding from a peptic ulcer. N Engl J Med 2008;359:928-37.
4. Leontiadis GI, Sharma VK, Howden CW. Proton pump inhibitor therapy for peptic ulcer bleeding: Cochrane collaboration meta-analysis of randomized controlled trials. Mayo Clin Proc 2007;82:286-96.
5. Sung JJ, Barkun A, Kuipers EJ et al. Intravenous esomeprazole for prevention of recurrent peptic ulce bleeding: a randomized trial. Ann Intern Med 2009;150:455-64.