A novel triple-regulated oncolytic adenovirus carrying PDCD5 gene exerts potent antitumor efficacy on common human leukemic cell lines

Apoptosis

Volumn 14, Issue 9, 2009, Pages 1086-1094

  Xie, Min ^a   Niu, Ji Hong ^a   Chang, Yan ^a   Qian, Qi Jun ^b   Wu, Hong Ping ^b   Li, Lin Fang ^b   Zhang, Yao ^a   Li, Jin Lan ^a   Huang, Xiao Jun ^a   Ruan, Guo Rui ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Conditionally replicating adenoviruses; Gene therapy; Leukemia; Nude mice; PDCD5

Indexed keywords

ANTINEOPLASTIC AGENT; CONDITIONALLY REPLICATING ADENOVIRUS; E1A PROTEIN; E1B PROTEIN; NUCLEOTIDE; PROGRAMMED CELL DEATH 5 PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA RESPONSIVE ELEMENT; DRUG EFFICACY; DRUG SAFETY; EMBRYO; FEMALE; GENE CASSETTE; GENE DELETION; GENE EXPRESSION; GENETIC ENGINEERING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; FLOW CYTOMETRY; GENE THERAPY; GREEN FLUORESCENT PROTEINS; HUMANS; LEUKEMIA; MICE; MUTAGENESIS, INSERTIONAL; NEOPLASM PROTEINS; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; TRANSGENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ADENOVIRIDAE; CYTOMEGALOVIRUS; MUS MUSCULUS;

EID: 68349125535     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0373-3     Document Type: Article

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