Insulin and non-insulin mediated vasodilation and glucose uptake in patients with type 2 diabetes

Diabetes Research and Clinical Practice

Volumn 85, Issue 3, 2009, Pages 243-251

  Scheede Bergdahl, Celena ^a   Olsen, David Benee ^a   Reving, Danny ^a   Boushel, Robert ^a   Dela, Flemming ^a  

^a Department of Biomedical Sciences   (Denmark)

Author keywords

Endothelial function; Forearm blood flow; Glucose extraction; Insulin; Type 2 diabetes

Indexed keywords

ACETYLCHOLINE; ADENOSINE; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOREARM BLOOD FLOW; GLUCOSE TRANSPORT; HUMAN; HYPERINSULINEMIA; INSULIN INFUSION; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCHOLINE; ADENOSINE; BLOOD FLOW VELOCITY; BLOOD GLUCOSE; BLOOD PRESSURE; BRACHIAL ARTERY; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; HALF-LIFE; HUMANS; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRA-ARTERIAL; INSULIN; MIDDLE AGED; NITROPRUSSIDE; OXYGEN CONSUMPTION; REFERENCE VALUES; VASODILATION; VASODILATOR AGENTS;

EID: 68349123586     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2009.06.029     Document Type: Article

References (31)

1. Baron A.D., Tarshoby M., Hook G., Lazaridis E.N., Cronin J., Johnson A., et al. Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Diabetes 49 (2000) 768-774
2. Clerk L.H., Vincent M.A., Jahn L.A., Liu Z., Lindner J.R., and Barrett EJ. Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes 55 (2006) 1436-1442
3. Eggleston E.M., Jahn L.A., and Barrett E.J. Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake. Diabetes 56 (2007) 2958-2963
4. Clerk L.H., Vincent M.A., Barrett E.J., Lankford M.F., and Lindner J.R. Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition. Am. J. Physiol. Endocrinol. Metab. 293 (2007) E1804-E1809
5. Coggins M., Lindner J., Rattigan S., Jahn L., Fasy E., Kaul S., et al. Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. Diabetes 50 (2001) 2682-2690
6. Zhang L., Vincent M.A., Richards S.M., Clerk L.H., Rattigan S., Clark M.G., et al. Insulin sensitivity of muscle capillary recruitment in vivo. Diabetes 53 (2004) 447-453
7. Gudbjornsdottir S., Sjostrand M., Strindberg L., and Lonnroth P. Decreased muscle capillary permeability surface area in type 2 diabetic subjects. J. Clin. Endocrinol. Metab. 90 (2005) 1078-1082
8. Laakso M., Edelman S.V., Brechtel G., and Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 41 (1992) 1076-1083
9. Dela F., Larsen J.J., Mikines K.J., and Galbo H. Normal effect of insulin to stimulate leg blood flow in NIDDM. Diabetes 44 (1995) 221-226
10. Yki-Jarvinen H. Insulin resistance and endothelial dysfunction. Best Pract. Res. Clin. Endocrinol. Metab. 17 (2003) 411-430
11. Barac A., Campia U., and Panza J.A. Methods for evaluating endothelial function in humans. Hypertension 49 (2007) 748-760
12. Higashi Y., and Yoshizumi M. New methods to evaluate endothelial function: method for assessing endothelial function in humans using a strain-gauge plethysmography: nitric oxide-dependent and -independent vasodilation. J. Pharmacol. Sci. 93 (2003) 399-404
13. Bryan P.T., and Marshall J.M. Cellular mechanisms by which adenosine induces vasodilatation in rat skeletal muscle: significance for systemic hypoxia. J. Physiol. 514 Part 1 (1999) 163-175
14. Olsson R.A., and Pearson JD. Cardiovascular purinoceptors. Physiol. Rev. 70 (1990) 761-845
15. Smits P., Williams S.B., Lipson D.E., Banitt P., Rongen G.A., and Creager MA. Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans. Circulation 92 (1995) 2135-2141
16. Costa F., and Biaggioni I. Role of nitric oxide in adenosine-induced vasodilation in humans. Hypertension 31 (1998) 1061-1064
17. Schulman I.H., Zhou M.S., Jaimes E.A., and Raij L. Dissociation between metabolic and vascular insulin resistance in aging. Am. J. Physiol. Heart Circ. Physiol. 293 (2007) H853-H859
18. Rask-Madsen C., Ihleman N., Krarup T., Christiansen E., Kober L., Kistorp C.N., et al. Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease. Diabetes 50 (2001) 2611-2618
19. Ray C.J., and Marshall J.M. The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium. J. Physiol. 570 (2006) 85-96
20. Tack C.J.J., Smits P., Willemsen J.J., Lenders J.W.M., Thien T., and Lutterman J.A. Effects of insulin on vascular tone and sympathetic nervous system in NIDDM. Diabetes 45 (1996) 15-22
21. Yki-Järvinen H., and Utriainen T. Insulin-induced vasodilation: physiology or pharmacology?. Diabetologia 41 (1998) 369-379
22. Clark M.G., Rattigan S., and Barrett E.J. Nutritive blood flow as an essential element supporting muscle anabolism. Curr. Opin. Clin. Nutr. Metab. Care 9 (2006) 185-189
23. Newman J.M., Ross R.M., Richards S.M., Clark M.G., and Rattigan S. Insulin and contraction increase nutritive blood flow in rat muscle in vivo determined by microdialysis of L-[14C]glucose. J. Physiol. 585 (2007) 217-229
24. Clerk L.H., Vincent M.A., Lindner J.R., Clark M.G., Rattigan S., and Barrett E.J. The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake. Diabetes Metab. Res. Rev. 20 (2004) 3-12
25. Olsen D.B., Sacchetti M., Dela F., Ploug T., and Saltin B. Glucose clearance is higher in arm than leg muscle in type 2 diabetes. J. Physiol. 565 (2005) 555-562
26. Helge J.W., Overgaard K., Damsgaard R., Sorensen K., Andersen J.L., Dyrskog S.E., et al. Repeated prolonged whole-body low-intensity exercise: effects on insulin sensitivity and limb muscle adaptations. Metabolism 55 (2006) 217-223
27. Taddei S., Virdis A., Mattei P., Natali A., Ferrannini E., and Salvatti A. Effect of insulin on acetylcholine-induced vasodilation in normotensive subjects and patients with essential hypertension. Circulation 92 (1995) 2911-2918
28. Serne E.H., IJzerman R.G., Gans R.O., Nijveldt R., De V.G., Evertz R., et al. Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia. Diabetes 51 (2002) 1515-1522
29. Natali A., Quinones G.A., Pecori N., Sanna G., Toschi E., and Ferrannini E. Vasodilation with sodium nitroprusside does not improve insulin action in essential hypertension. Hypertension 31 (1998) 632-636
30. McGrowder D., Ragoobirsingh D., and Brown P. Acute effects of exogenous nitric oxide on glucose uptake in skeletal muscle of normoglycaemic and diabetic rats. Med. Sci. Monit. 12 (2006) BR28-BR35
31. McGrowder D., Ragoobirsingh D., and Brown P. Modulation of glucose uptake in adipose tissue by nitric oxide-generating compounds. J. Biosci. 31 (2006) 347-354