Pulmonary effects of nebivolol

Therapeutic Advances in Cardiovascular Disease

Volumn 3, Issue 4, 2009, Pages 329-334

  Dal Negro, Roberto ^a  

^a Orlandi General Hospital   (Italy)

Author keywords

Arterial hypertension; Bronchial asthma; Chronic obstructive pulmonary disease; Nebivolol; adrenergic receptor antagonists

Indexed keywords

ATENOLOL; BISOPROLOL; CELIPROLOL; NEBIVOLOL; NITRIC OXIDE; PLACEBO; PROPRANOLOL; SALBUTAMOL; TERBUTALINE;

ANTIOXIDANT ACTIVITY; ASTHMA; BLOOD PRESSURE REGULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; COMORBIDITY; DIASTOLIC BLOOD PRESSURE; DRUG ACTIVITY; DRUG EFFICACY; ENZYME SYNTHESIS; FLOW RATE; FORCED EXPIRATORY VOLUME; HEART RATE; HUMAN; HYPERTENSION; LUNG FUNCTION; NONHUMAN; OXYGEN TRANSPORT; PHARMACODYNAMICS; PRIORITY JOURNAL; REVIEW; TREATMENT RESPONSE; VASODILATATION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; ASTHMA; BENZOPYRANS; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; ETHANOLAMINES; HUMANS; HYPERTENSION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; TREATMENT OUTCOME;

EID: 68349121443     PISSN: 17539447     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753944709339968     Document Type: Review

References (29)

1. Agabiti-Rosei, E. and Rizzoni, D. (2007) Metabolic profile of nebivolol, a beta-adrenoceptor antagonist with unique characteristics. Drugs 67: 1097-1107.
2. Brooders, M., Doevendans, P.A. and Bekkers, B.C. (2000) Nebivolol: a third generation beta-blocker that augments vascular nitric oxide release: endothelial beta (2)-adrenergic receptor-mediated nitric oxide production. Circulation 102: 677-684.
3. Cazzola, M., Matera, M.G., Ruggeri, P., Sanduzzi, A., Spicuzza, L., Vatrella, A. et al. (2004) Comparative effects of a two-week treatment with nebivolol and nifedipine in hypertensive patients suffering from COPD. Respiration 71: 159-164.
4. Cazzola, M., Noschese, P., D'Amato, M. and D'Amato, G. (2000) Comparison of the effects of single oral doses of nebivolol and celiprolol on airways in patients with mild asthma. Chest 118: 1322-1326.
5. Cockroft, J. (2007) A review of the safety and efficacy of nebivolol in the midly hypertensive patient. Vasc Health Risk Manag 3: 909-917.
6. Cockroft, J. (2004) Nebivolol: a review. Expert Opin Pharmacother 5: 839-893.
7. Dal Negro, R. and Turco, P. (1981) Changes in alveolar ventilation distribution due to β antagonists induced by four different drugs in patients with COPD. Intern J Clin Pharmacol 19: 234-235.
8. Dal Negro, R., Tognella, S. and Micheletto, C. (2002 a) Pharmacokinetics of the effect of nebivolol 5 mg on airway patency in patients with mild to moderate bronchial asthma and arterial hypertension. A randomised, placebo controlled study. Clin Drug Invest 22: 197-204.
9. Dal Negro, R., Tognella, S. and Pomari, C. (2002 b) Once-daily nebivolol 5 mg does not reduce airway patency in patients with chronic obstructive pulmonary disease and arterial hypertension. A placebo controlled cross-over study. Clin Drug Invest 22: 1-7.
10. Dal Negro, R.W., Tognella, S., Donner, C.F., Tosatto, R., Dionisi, M. and Turco, P. (2007) Costs of chronic obstructive pulmonary disease (COPD) in Italy: the SIRIO study (Social Impact of Respiratory Integrated Outcomes). Respiratory Medicine 102: 92-101.
11. de Boer, R.A., Voors, A.A. and van Veldhuisen, D.J. (2007) Nebivolol: third generation beta-blockade. Expert Opin Pharmacother 8: 1539-1550.
12. de Clerck, F., van Gorp, L., Loots, W. and Janssen, P.A. (1989) Differential effects of nebivolol, atenolol and propranolol on heart rate and on bronchoconstrictor responses to histamine in the guinea-pig. Arch Int Pharmacodyn Ther 298: 230-236.
13. Franciosa, J.A. (1999) Beta-adrenergic blocking agents: past, present and future perspectives. Coron Artery Dis 10: 369-376.
14. Iakushin, S.S., Okorokov, V.G., Liferov, R.A., Fomina, V.A. and Ivanova, G.O. (2002) Assessment of safety and anti-hypertensive efficacy of a cardioselective beta-blocker nebivolol in patients with hypertension and concomitant chronic obstructive bronchitis. Kardiologia 42: 36-39.
15. Janssen, W., de Water, A. and Xhonneux, R. (1989) Nebivolol is devoid of intrinsic sympathomimetic activity. Eur J Pharmacol 159: 89-95.
16. Lombardo, R.M., Reina, C., Abrignani, M.G., Rizzo, P.A., Braschi, A. and de Castro, S. (2006) Effects of nebivolol versus carvedilol on left ventricular function in patients with chronic heart failure and reduced left ventricular systolic function. Am J Cardiovasc Drugs 6: 259-263.
17. Mangrella, M., Rossi, F. and Fici, F. (1998) Pharmacology of nebivolol. Pharmacol Res 38: 419-431.
18. Matthys, H., Giebelhaus, V. and von Fallois, J. (2001) Nebivolol (nebilet) a beta blocker of the third generation also for patients with obstructive lung diseases. Kardiologia 90: 760-765.
19. McNeely, W. and Goa, K.L. (1999) Nebivolol in the management of essential hypertension: a review. Drugs 57: 633-651.
20. McNeill, R.S. and Ingram, C.G. (1966) Effect of propranolol on ventilatory function. Am J Cardiol 18: 473-475.
21. Mohammed, A.F., Hulks, G. and Thompson, N.C. (1991) Effects of nebivolol, atenolol, and propranolol on airway β-adrenergic responsiveness in normal subjects. Drug Invest 3: 196-198.
22. Nuttali, S.L., Routledge, H.C. and Kendall, M.J. (2003) A comparison of the beta 1 selectivity of three beta1-selective beta-blockers. Clin Pharm Ther 28: 179-186.
23. Ovcharenko, S.T., Litvinova, I.V. and Mikolkin, V.I. (2007) Administration of cardioselective betaadrenoblockers in patients with arterial hypertension and / or ischemic heart disease associated with bronchoobstructive syndrome. Ter Arkh 79: 12-18.
24. Ryo, U.Y. and Townley, R.G. (1976) Comparison of respiratory and cardiovascular effects of isoptroterenol, propranolol and practolol in asthmatic and normal subjects. J Allergy Clin Immunol 57: 12-24.
25. Szentivanyi, A. (1968) The beta adrenergic theory of the atopic abnormality in bronchial asthma. J Allergy 42: 203-232.
26. Tafreshi, M.J. and Weinacker, A.B. (1999) β-adrenergic blocking agents in bronchospastic diseases: a theraputic dilemma. Pharmacotherapy 19: 974-978.
27. Townley, R.G., McGeady, S. and Bewtra, A. (1976) The effect of beta-adrenergic blockade on bronchial-sensitivity to acetyl-beta-methacholine in normal and allergic rhinitis subjects. J Allergy Clin Immunol 57: 358-366.
28. Viegi, G., Scognamiglio, A., Baldacci, S., Pistelli, F. and Carrozzi, L. (2001) Epidemiology of chronic obstructive pulmonary disease (COPD). Respiration 68: 4-19.
29. Zinchuk, V.V. and Zinchuk, N.V. (2007) Effect of nebivolol on the blood oxygen transport. Eksp Klin Farmakol 70: 44-47.