Migraine: Telcagepant provides new hope for people with migraine

Nature Reviews Neurology

Volumn 5, Issue 5, 2009, Pages 240-242

  Edvinsson, Lars ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; OLCEGEPANT; PLACEBO; TELCAGEPANT; TRIPTAN DERIVATIVE; UNCLASSIFIED DRUG; ZOLMITRIPTAN; AZEPINE DERIVATIVE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; IMIDAZOLE DERIVATIVE; N (6 (2,3 DIFLUOROPHENYL) 2 OXO 1 (2,2,2 TRIFLUOROETHYL)AZEPAN 3 YL) 4 (2 OXO 2,3 DIHYDRO 1H IMIDAZO(4,5 B)PYRIDIN 1 YL)PIPERIDINE 1 CARBOXAMIDE; N-(6-(2,3-DIFLUOROPHENYL)-2-OXO-1-(2,2,2-TRIFLUOROETHYL)AZEPAN-3-YL)-4-(2-OXO-2,3-DIHYDRO-1H-IMIDAZO(4,5-B)PYRIDIN-1-YL)PIPERIDINE-1-CARBOXAMIDE;

ACUTE CHEST SYNDROME; ANALGESIA; ARTICLE; ASTHENIA; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG DOSE COMPARISON; FATIGUE; HEADACHE; HUMAN; MIGRAINE; NAUSEA; NAUSEA AND VOMITING; PHONOPHOBIA; PHOTOPHOBIA; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT; VERTIGO; DRUG ANTAGONISM; NOTE;

AZEPINES; CLINICAL TRIALS AS TOPIC; HUMANS; IMIDAZOLES; MIGRAINE DISORDERS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE;

EID: 68349089395     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2009.49     Document Type: Article

References (10)

1. (1B/1D) agonists) in acute migraine treatment: A meta-analysis of 53 trials. Lancet 358, 1668-1675 (2001).
2. 1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect. Clin. Sci. (Lond.) 109, 335-342 (2005).
3. Ho, T. W. et al. Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: A randomized, placebo-controlled, parallel-treatment trial, Lancet 372, 2115-2123 (2008).
4. McCulloch, J., Uddman, R., Kingman, T. A. & Edvinsson, L. Calcitonin gene-related peptide: Functional role in cerebrovascular regulation. Proc. Natl. Acad. Sci USA 83, 5731-5735 (1986).
5. Liu, Y., Broman, J. & Edvinsson, L. Central projections of the sensory innervation of the rat middle meningeal artery. Brain Res. 1208 103-110 (2008).
6. Goadsby, P. J., Edvinsson, L. & Ekman, R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann. Neurol. 28, 183-187 (1990).
7. Olesen, J. et al. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N. Engl. J. Med. 350, 1104-1110 (2004).
8. Ho, T. W. et al. Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine. Neurology 70, 1304-1312 (2008).
9. Edvinsson, L. et al. Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells. Eur. J. Pharmacol. 434, 49-53 (2002).
10. Regan, C. P., Stump, G. L., Kane, S. A. & Lynch, J. J. Jr Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis. J. Pharmacol. Exp. Ther. 328, 571-578 (2009).