A QSAR study investigating the potential anti-HIV-1 effect of some acyclovir and ganciclovir analogs

Arkivoc

Volumn 2009, Issue 8, 2009, Pages 85-94

  Almerico, Anna Maria ^a   Tutone, Marco ^a   Lauria, Antonino ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Anti HIV 1 activity; BMLR; Neural network; QSAR

Indexed keywords

EID: 68349088165     PISSN: 1551-7012     EISSN: 15517012     Source Type: Journal    
DOI: 10.3998/ark.5550190.0010.808     Document Type: Article

References (8)

1. Diana, P.; Barraja, P.; Almerico, A. M.; Dattolo, G.; Mingoia, F.; Loi, A. G.; Congeddu, E.; Musiu, C.; Putzolu, M.; La Colla, P. Il Farmaco 1997, 52, 281.
2. Almerico, A. M.; Diana, P.; Barraja, P.; Dattolo, G.; Mingoia, F.; Putzolu, M.; Perra, G.; Milia, C.; Musiu, C.; Marongiu, M. E. Il Farmaco 1997, 52, 667.
3. Almerico, A. M.; Diana, P.; Barraja, P.; Dattolo, G.; Mingoia, F.; Loi, A. G.; Scintu, F.; Milia, C.; Puddu, I.; La Colla, P. Il Farmaco 1998, 53, 33.
4. Almerico, A. M. Barraja, P.; Diana, P.; Cirrincione, G.; Mingoia, F.; Musiu, C.; Perra, G.; Putzolu, M.; Pinna, N.; La Colla, P. Il Farmaco 1998, 53, 409.
5. All the calculations were run on a Silicon Graphics Indigo II workstation by using the softwares TSAR 3.2 (Tools for Structure Activity Relationships), VAMP 6.0, ASP 3.2 (Automated Similarity Packages) by Oxford Molecular - Accelrys.
6. Zupan, J.; Gasteiger, J. Neural Networks for Chemists: An Introduction; VCH: Weinheim, 1993.
7. Molecular descriptors were derived according to the method and assumptions reported in TSAR 3.2 Reference Guide, 1998, Oxford Molecular Limited.
8. More detailed procedure can be found in the TSAR Reference and User guides, 1998, Oxford Molecular Limited.