In vivo evaluation of injectable thermosensitive polymer with time-dependent LCST

Journal of Biomedical Materials Research - Part A

Volumn 90, Issue 4, 2009, Pages 1186-1197

  Henderson, Eric ^a   Lee, Bae Hoon ^a   Cui, Zhanwu ^a   McLemore, Ryan ^a   Brandon, Tedd A ^a   Vernon, Brent L ^a  

^a Arizona State University   (United States)

Author keywords

Bioresorption; Hydrogel; Hydrolysis; Thermally responsive material

Indexed keywords

ACRYLIC ACIDS; BIORESORPTION; BUTYROLACTONES; CO-POLYMER SYSTEMS; DIFFUSION RATE; HYDROLYTIC DEGRADATION; IMPLANT INTERFACES; IMPLANT-TISSUE INTERFACES; IN-VITRO; IN-VIVO; NMR MEASUREMENTS; NORMAL TISSUE; POLYMER IMPLANTS; POST-IMPLANTATION; SPRAGUE-DAWLEY RATS; THERMALLY RESPONSIVE MATERIAL; THERMO-SENSITIVE POLYMER; TIME-DEPENDENT; TISSUE SECTIONS; WOUND HEALING;

ANIMALS; BIOCOMPATIBILITY; CARBOXYLIC ACIDS; CELL CULTURE; COPOLYMERIZATION; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE; ORGANIC ACIDS; POLYMERS; SWELLING;

HYDROGELS;

ACRYLIC ACID; BUTYROLACTONE; DIMETHYL GAMMA BUTYROLACTONE; POLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FIBROBLAST; HEAT SENSITIVITY; HISTOPATHOLOGY; IMPLANT; IN VIVO STUDY; LEUKOCYTE; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL COUNT; DIFFUSION; FIBROBLASTS; HOT TEMPERATURE; HYDROLYSIS; IMPLANTS, EXPERIMENTAL; INJECTIONS; LEUKOCYTES; MATERIALS TESTING; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; WOUND HEALING;

EID: 68249160671     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32179     Document Type: Article

References (15)

1. Jeong B, Kim SW, Bae YH. Thermosensitive sol-gel reversible hydrogels. Adv Drug Deliv Rev 2002;54:37-51.
2. Zentner GM, Rathi R, Shih C, McRea JC, Seo MH, Oh H, Rhee BG, Mestecky J, Moldoveanu Z, Morgan M, Weitman S. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. J Control Release 2001;72:203-215.
3. Behravesh E, Jo S, Zygourakis K, Mikos AG. Synthesis of in situ cross-linkable macroporous biodegradable poly(propylene fumarate -co-ethylene glycol) hydrogels. Biomacromolecules 2002;3:374-381.
4. Chenite A, Chaput C, Wang D, Combes C, Buschmann MD, Hoemann CD, Leroux JC, Atkinson BL, Binette F, Selmani A. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials 2000;21:2155-2161.
5. Lee BH, Song SC. Synthesis and characterization of biodegradable thermosensitive poly(organophosphazene gels). Macromolecules 2004;37:4533-4537.
6. Lee SB, Song SC, Jin JI, Sohn YS. A new class of biodegradable thermosensitive polymers. II. Hydrolytic properties and salt effect on the lower critical solution temperature of poly (organophosphazenes) with methoxypoly(ethylene glycol) and amino acid esters as side groups. Macromolecules 1999; 32:7820-7827.
7. Lee BH, Vernon B. In situ-gelling, erodible N-isopropylacrylamide copolymers. Macromol Biosci 2005;5:629-635.
8. Heskins M, Guillet JE. Solution properties of poly( N-isopropylacrylamide). J Macromol Sci Chem 1968;A2:1441-1455.
9. Kim S, Healy KE. Synthesis and characterization of injectable poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with proteolytically degradable cross-links. Biomacromolecules 2003;4:1214-1223.
10. Neradovic D, Hinrichs W, Kettens-van den Bosch JJ, Hennink WE. Poly(N-isopropylacrylamide) with hydrolyzable lactic acid ester side groups: A new type of thermosensitive polymer. Macromol Rapid Commun 1999;20:577-581.
11. Neradovic D, van Nostrum CF, Hennink WE. Thermoresponsive polymeric micelles with controlled instability based on hydrolytically sensitive N-isopropylacrylamide copolymers. Macromolecules 2001;34:7589-7591.
12. Cui Z, Lee BH, Henderson E, Vernon B. In N-isopropylacrylamide- based copolymer with hydrolysis-dependent lower critical solution temperature as injectable, bioresorbable gelling materials for controlled drug delivery, Society for Biomaterials, Pittsburg, 2006.
13. Cui Z, Lee BH, Vernon B. New hydrolysis-dependent thermosensitive polymer for an injectable degradable system. Biomacromolecules 2007;8:1280-1286.
14. Peppas NA, Khare AR. Preparation, structure and diffusional behavior of hydrogels in controlled release. Adv Drug Deliv Rev 1993;11:1-35.
15. Dee KC, Puleo DA, Bizios R. An Introduction to Tissue-Biomaterial Interactions. New Jersey: Wiley; 2002. p 127-147.