Digitalis must be banished from the table: A rare case of acute accidental Digitalis intoxication of a whole family

Journal of Cardiovascular Medicine

Volumn 10, Issue 9, 2009, Pages 727-732

  Maffè, Stefano ^a   Cucchi, Lorenzo ^a   Zenone, Franco ^a   Bertoncelli, Cristina ^a   Beldì, Federico ^a   Colombo, Maria Laura ^b   Bielli, Massimo ^a   Paino, Anna Maria ^a   Parravicini, Umberto ^a   Paffoni, Paola ^a   Dellavesa, Pierfranco ^a   Perucca, Antonello ^a   Pardo, Nicolò Franchetti ^a   Signorotti, Fabiana ^a   Didino, Claudio ^a   Zanetta, Marco ^a  

^a Division of Cardiology SS Trinità Borgomanero Hospital   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Digitalis intoxication; Digoxin specific antibody

Indexed keywords

BISOPROLOL; DIGITALIS; DIGOXIN ANTIBODY F(AB) FRAGMENT;

ADULT; ARTICLE; ATRIOVENTRICULAR BLOCK; BORAGO; BRADYCARDIA; CASE REPORT; CLINICAL FEATURE; DIAGNOSTIC IMAGING; DIGITALIS INTOXICATION; DIGITALIS PURPUREA; DISEASE COURSE; FAMILY; FEMALE; FOOD CONTAMINATION; HUMAN; IMAGE ANALYSIS; LETHARGY; MALE; MEDICINAL PLANT; NAUSEA; POTATO; ST SEGMENT DEPRESSION; SYMPTOM; VOMITING; WEAKNESS;

ACUTE DISEASE; ADULT; ANTIDOTES; BRADYCARDIA; CARDIAC GLYCOSIDES; CHARCOAL; DIGITALIS; ELECTROCARDIOGRAPHY; FEMALE; FOOD CONTAMINATION; HEART RATE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MALE; MIDDLE AGED; PLANT LEAVES; POISONING;

EID: 68249159594     PISSN: 15582027     EISSN: None     Source Type: Journal    
DOI: 10.2459/JCM.0b013e32832c2314     Document Type: Article

References (19)

1. Smith TW, Haber E, Yeatman L, Butler VP Jr. Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies. N Engl J Med 1976; 294:797-800.
2. Watson WA, Litovitsìz TL, Rodgers GC Jr, Klein-Schwartz W, Youniss J, Rose SR, et al. 2002 Annual report of the American Association of Poison Control Center Toxic Exposure Surveillance System. Am J Emerg Med 2002; 21:353-421.
3. Chase M. An update of the Angiosperm Phylogeny Group classifications for the orders and families of flowering plants: APG II. Bot J Linn Soc 2003; 141:399-436. (Pubitemid 36463424)
4. Hoffman BF, Bigger TJ. Digitalis and allied cardiac glycosides. In: Gilman AG, Goodman LS, Rall TW,Murad F, editors. The pharmacological basis of therapeutics. New York: Pergamon Press; 1990. pp. 814-839.
5. Slifman NR, Obermeyer WR, Musser SM, Correll WA, Cichowicz SM, Betz JM, Love LA. Contamination of botanical dietary supplements by Digitalis lanata. N Engl J Med 1998; 339:806-811.
6. Allen G. The affinity of binding of digoxin to ovine antidigoxin Fab (DIGIBIND) preparations. Biologicals 1996; 24:19-24. (Pubitemid 26148439)
7. Bismuth C, Motte G, Conso F, Chauvin M, Gaultier M. Acute digoxin intoxication treated by intracardiac pace maker: experience in sixty-eight patients. Clin Toxicol 1997; 10:443-456.
8. Taboulet P, Baud FJ, Bismuth C. Clinical features and management of digitalis poisoning: rationale for immunotherapy. J Toxicol Clin Toxicol 1993; 31:247-260. (Pubitemid 23159968)
9. Hickey AR, Wenger TL, Carpenter VP, Tilson HH, Hlatky MA, Furberg CD, et al. Digoxin immune Fab therapy in the management of digitalis intoxication: safety and efficacy results of an observational surveillance study. J Am Coll Cardiol 1991; 17:590-598.
10. Borron SW, Bismuth C, Muszynski J. Advances in the management of digoxin toxicity in the older patient. Drugs Aging 1997; 10:18-33. (Pubitemid 27057935)
11. Ellenhorn MJ. Antiarrythmic drugs. Digitalis. In: Ellenhorn MJ, editor. Medical toxicology. New York: Elsevier; 1997. pp. 541-549.
12. Lapostolle F, Borron SW, Verdier C, Taboulet P, Adnet F, Clemessy JL, et al. Digoxin-specific Fab fragments as single first-line therapy in digitalis poisoning. Crit Care Med 2008; 36:3014-3018.
13. Lapostolle F, Borron SW, Verdier C, Arnaud F, Couvreur J, Mégarbane B, et al. Assessment of digoxin antibody use in patients with elevated serum digoxin following chronic or acute exposure. Intensive Care Med 2008; 34:1448-1453.
14. Hess T, Riesen W, Scholtysik G, Stucki P. Digitoxin intoxication with severe thrombocytopenia: reversal by digoxin-specific antibodies. Eur J Clin Invest 1983; 13:159-163. (Pubitemid 13163426)
15. Conti L, Fidani P, Chistolini A, Francesconi M, Gandolfo GM, Mazzucconi MG. Detection of drug-dependent IgG antibodies with antiplatelet activity by the antiglobulin consumption assay. Haemostasis 1984; 14:480-486. (Pubitemid 15107107)
16. Seltsam A, Salama A. Ceftriaxone-induced immune haemolysis: two case reports and a concise review of the literature. Intensive Care Med 2000; 26:1390-1394. (Pubitemid 30743909)
17. Hull RL, Brandon D. Thrombocytopenia possibly caused by structurally related third-generation cephalosporins. DICP 1991; 25:135-136.
18. Grossjohann B, Eichler P, Greinacher A, Santoso S, Kroll H. Ceftriaxone causes drug-induced immune thrombocytopenia and haemolytic anemia: characterization of targets on platelets and red blood cells. Transfusion 2004; 44:1033-1040. (Pubitemid 38823810)
19. Ernst E. Harmless herbs? A review of the recent literature. Am J Med 1988;104:170-178.