Nanocrystalline silver: A systematic review of randomized trials conducted on burned patients and an evidence-based assessment of potential advantages over older silver formulations

Annals of Plastic Surgery

Volumn 63, Issue 2, 2009, Pages 201-205

  Gravante, Gianpiero ^a,c   Caruso, Riccardo ^b   Sorge, Roberto ^b   Nicoli, Fabio ^b   Gentile, Pietro ^b   Cervelli, Valerio ^b  

^a UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

Burns; Nanocrystalline silver; Silver dressings; Wound infections

Indexed keywords

ACTICOAT; AQUACEL AG; CONVATEC; NANOCRYSTAL; NANOCRYSTALLINE SILVER; SILVAZINE; SILVER; SILVER NITRATE; SULFADIAZINE SILVER; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BURN; CLINICAL TRIAL; EVIDENCE BASED MEDICINE; HOSPITALIZATION; HUMAN; INCIDENCE; INFECTION PREVENTION; META ANALYSIS; OUTCOMES RESEARCH; PAIN; PAIN ASSESSMENT; PATIENT SELECTION; PRIORITY JOURNAL; SYSTEMATIC REVIEW; WOUND DRESSING; WOUND INFECTION;

ADMINISTRATION, TOPICAL; BURNS; CHI-SQUARE DISTRIBUTION; EVIDENCE-BASED MEDICINE; HUMANS; NANOPARTICLES; OUTCOME ASSESSMENT (HEALTH CARE); RANDOMIZED CONTROLLED TRIALS AS TOPIC; SILVER; WOUND HEALING;

EID: 68249146101     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/SAP.0b013e3181893825     Document Type: Article

References (48)

1. George N, Faoagali J, Muller M. Silvazine (silver sulfadiazine and chlorhexidine) activity against 200 clinical isolates. Burns. 1997;23:493-495. (Pubitemid 27527101)
2. Thomas V, Yallapu MM, Sreedhar B, et al. A versatile strategy to fabricate hydrogel-silver nanocomposites and investigation of their antimicrobial activity. J Colloid Interface Sci. 2007;315:389-395. (Pubitemid 47410046)
3. Barreiro E, Casas JS, Couce MD, et al. Synthesis and antimicrobial activities of silver (I) sulfanylcarboxylates. Structural isomers with identically or unequally coordinated Ag centers in an Ag4S4 ring. Dalton Trans. 2007;28: 3074-3085. (Pubitemid 47152317)
4. Leaper DJ. Silver dressings: their role in wound management. Int Wound J. 2006;3:282-294.
5. Bragg PD, Rainnie DJ. The effect of silver ions on the respiratory chain of E. coli. Can J Microbiol. 1974;20:883-889.
6. Modak SM, Fox CL. Binding of silver sulphadizine to the cellular components of Pseudomonas aeruginosa. Biochem Pharmacol. 1973;22:2391-2404.
7. Dowsett C. The use of silver-based dressings in wound care. Nurs Stand. 2004;19:56-60.
8. Dowsett C. An overview of Acticoat dressing in wound management. Br J Nurs. 2003;12(suppl 19):S44-S49.
9. O'Meara SM, Cullum NA, Majid M, et al. Systematic review of antimicrobial agents used for chronic wounds. Br J Surg. 2001;88:4-21. (Pubitemid 32066051)
10. Bolton L. Are silver products safe and effective for chronic wound management? J Wound Ostomy Continence Nurs. 2006;33:469-477. (Pubitemid 44915806)
11. Meaume S, Vallet D, Morere MN, et al. Evaluation of a silver-releasing hydroalginate dressing in chronic wounds with signs of local infection. J Wound Care. 2005;14:411-419. (Pubitemid 44574270)
12. Atiyeh BS, Costagliola M, Hayek SN, et al. Effect of silver on burn wound infection control and healing: review of the literature. Burns. 2007;33: 139-148. (Pubitemid 46188672)
13. Dunn K, Edwards-Jones V. The role of Acticoat with nanocrystalline silver in the management of burns. Burns. 2004;30(suppl 1):S1-S9. (Pubitemid 39140960)
14. Gravante G, Esposito G, Delogu D, et al. Silver dressings: a clinical perspective. Plast Reconstr Surg. 2007;119:429-430.
15. Tredget EE, Shankowsky HA, Groeneveld A, et al. A matched-pair, randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. J Burn Care Rehabil. 1998;19:531-537. (Pubitemid 28549808)
16. Fong J, Wood F, Fowler B. A silver coated dressing reduces the incidence of early burn wound cellulitis and associated costs of inpatient treatment: comparative patient care audits. Burns. 2005;31:562-567. (Pubitemid 40905213)
17. Varas RP, O'Keeffe T, Namias N, et al. A prospective, randomized trial of Acticoat versus silver sulfadiazine in the treatment of partial-thickness burns: which method is less painful? J Burn Care Rehabil. 2005;26:344-347. (Pubitemid 41074519)
18. Muangman P, Chuntrasakul C, Silthram S, et al. Comparison of efficacy of 1% silver sulfadiazine and Acticoat for treatment of partial-thickness burn wounds. J Med Assoc Thai. 2006;89:953-958. (Pubitemid 44099138)
19. Peters DA, Verchere C. Healing at home: Comparing cohorts of children with medium-sized burns treated as outpatients with in-hospital applied Acticoat to those children treated as inpatients with silver sulfadiazine. J Burn Care Res. 2006;27:198-201. (Pubitemid 43970322)
20. Burd A, Kwok CH, Hung SC, et al. A comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models. Wound Repair Regen. 2007;15:94-104. (Pubitemid 46146668)
21. Ulkur E, Oncul O, Karagoz H, et al. Comparison of silver-coated dressing (Acticoat), chlorhexidine acetate 0.5% (Bactigrass), and silver sulfadiazine 1% (Silverdin) for topical antibacterial effect in Pseudomonas aeruginosa- contaminated, full-skin thickness burn wounds in rats. J Burn Care Rehabil. 2005;26:430-433. (Pubitemid 41433683)
22. Ulkur E, Oncul O, Karagoz H, et al. Comparison of silver-coated dressing (Acticoat), chlorhexidine acetate 0.5% (Bactigrass), and fusidic acid 2% (Fucidin) for topical antibacterial effect in methicillin-resistant Staphylococci- contaminated, full-skin thickness rat burn wounds. Burns. 2005;31: 874-877. (Pubitemid 41394145)
23. Acikel C, Oncul O, Ulkur E, et al. Comparison of silver sulfadiazine 1%, mupirocin 2%, and fusidic acid 2% for topical antibacterial effect in methicillin- resistant staphylococci-infected, full-skin thickness rat burn wounds. J Burn Care Rehabil. 2003;24:37-41. (Pubitemid 36152560)
24. Fraser JF, Bodman J, Sturgess R, et al. An in vitro study of the anti-microbial efficacy of a 1% silver sulphadiazine and 0.2% chlorhexidine digluconate cream, 1% silver sulphadiazine cream and a silver coated dressing. Burns. 2004;30:35-41. (Pubitemid 38029122)
25. Paddock HN, Fabia R, Giles S, et al. A silver impregnated antimicrobial dressing reduces hospital length of stay for pediatric patients with burns. J Burn Care Res. 2007;28:409-411. (Pubitemid 46733247)
26. Paddock HN, Fabia R, Giles S, et al. A silver-impregnated antimicrobial dressing reduces hospital costs for pediatric burn patients. J Pediatr Surg. 2007;42:211-213. (Pubitemid 46037739)
27. Caruso DM, Foster KN, Blome-Eberwein SA, et al. Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns. J Burn Care Res. 2006;27:298-309.
28. Afilalo M, Dankoff J, Guttman A, et al. DuoDERM hydroactive dressing versus silver sulphadiazine/Bactigras in the emergency treatment of partial skin thickness burns. Burns. 1992;18:313-316.
29. Bugmann P, Taylor S, Gyger D, et al. A silicone-coated nylon dressing reduces healing time in burned paediatric patients in comparison with standard sulfadiazine treatment: a prospective randomized trial. Burns. 1998;24: 609-612. (Pubitemid 29002578)
30. Silver GM, Robertson SW, Halerz MM, et al. A silver-coated antimicrobial barrier dressing used postoperatively on meshed autografts: a Dressing Comparison Study. J Burn Care Res. 2007;28:715-719.
31. Huang Y, Li X, Liao Z, et al. A randomized comparative trial between Acticoat and SD-Ag in the treatment of residual burn wounds, including safety analysis. Burns. 2007;33:161-166. (Pubitemid 46201863)
32. Gelfand JA. Infections in burn patients: a paradigm for cutaneous infection in the patient at risk. Am J Med. 1984;76:158-165.
33. Church D, Elsayed S, Reid O, et al. Burn wound infections. Clin Microbiol Rev. 2006;19:403-434.
34. Mousa HA. Aerobic, anaerobic and fungal burn wound infections. J Hosp Infect. 1997;37:317-323. (Pubitemid 28025087)
35. Mousa HA. Fungal infection of burn wounds in patients with open and occlusive treatment methods. East Mediterr Health J. 1999;5:333-336.
36. Becker WK, Cioffi WG, McManus AT. Fungal burn wound infection. A 10-year experience. Arch Surg. 1991;126:44-48.
37. Rutan RL. Physiologic response to cutaneous burn injury. In: Carrougher GJ. Burn Care and Therapy. St.Louis, MO: Mosby;1998:9-11.
38. Hansbrough JF, Zapata-Sirvent R, Hoyt D. Postburn immune suppression: an inflammatory response to the burn wound? J Trauma. 1990;30:671-674. (Pubitemid 20197979)
39. Blazar BA, Rodrick ML, O'Mahony JB, et al. Suppression of natural killer-cell function in humans following thermal and traumatic injury. J Clin Immunol. 1986;6:26-36.
40. Hansbrough JF, Field TO Jr, Gadd MA, et al. Immune response modulation after burn injury: T cells and antibodies. J Burn Care Rehabil. 1987;8: 509-512.
41. Gravante G, Palmieri MB, Esposito G, et al. Apoptotic cells are present in ischemic zones of deep partial-thickness burns. J Burn Care Res. 2006;27: 688-693. (Pubitemid 44450642)
42. Gravante G, Palmieri MB, Esposito G, et al. Apoptotic death in deep partial thickness burns vs. normal skin of burned patients. J Surg Res. 2007;141: 141-145. (Pubitemid 47042043)
43. Klasen HJ. Historical review of the use of silver in the treatment of burns. Burns. 2000;26:117-130. (Pubitemid 30050604)
44. Thomas S, McCubbin P. A comparison of the antimicrobial effects of four silver-containing dressings on three organisms. J Wound Care. 2003;12: 101-107.
45. Thomas S, McCubbin P. An in vitro analysis of the antimicrobial properties of 10 silver-containing dressings. J Wound Care. 2003;12:305-308.
46. Yin HQ, Langford R, Burrell RE. Comparative evaluation of the antimicrobial activity of ACTICOAT antimicrobial barrier dressing. J Burn Care Rehabil. 1999;20:195-200. (Pubitemid 29226503)
47. Sheridan R, Petera L, Lydon M, et al. Once-daily wound cleansing and dressing change: efficacy and cost. J Burn Care Rehabil. 1997;18:139-140. (Pubitemid 27149238)
48. O'Meara S, Al-Kurdi D, Ovington LG. Antibiotics and antiseptics for venous leg ulcers. Cochrane Database Syst Rev. 2008;1:CD003557. (Pubitemid 351807485)