Reversal of postprandial endothelial dysfunction by cyclooxygenase inhibition in healthy volunteers

Journal of Cardiovascular Pharmacology

Volumn 54, Issue 1, 2009, Pages 90-93

  Signori, Luis Ulisses ^a,b   Da Silva, Antônio Marcos Vargas ^c   Plentz, Rodrigo Della Méa ^a   Moreno Jr , Heitor ^d   Irigoyen, Maria Cláudia ^e   Schaan, Beatriz D'Agord ^a,f,g  

^a INSTITUTO DE CARDIOLOGIA DO RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^d UNIVERSITY OF CAMPINAS   (Brazil)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^g Unidade de Pesquisa   (Brazil)

Author keywords

Aspirin; Cyclooxygenase inhibitors; Endothelium; Lipid metabolism; Postprandial period

Indexed keywords

ACETYLCHOLINE; ACETYLSALICYLIC ACID; GLUCOSE; INSULIN; LIPID; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; ENDOTHELIUM CELL; ENDOTHELIUM LESION; FAT INTAKE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; VASOCONSTRICTION; VASODILATATION;

ACETYLCHOLINE; ADULT; ASPIRIN; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CYCLOOXYGENASE INHIBITORS; ENDOTHELIUM, VASCULAR; FASTING; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LIPID METABOLISM; LIPIDS; MALE; PHENYLEPHRINE; POSTPRANDIAL PERIOD; TIME FACTORS; TRIGLYCERIDES; VASODILATION; VEINS;

EID: 68249139935     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181abc26f     Document Type: Article

References (18)

1. Anderson RA, Evans ML, Ellis GR, et al. The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes. Atherosclerosis. 2001;154: 475-483.
2. Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA. 1997;278: 1682-1686.
3. Nappo F, Esposito K, Cioffi M, et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol. 2002;39:1145-1150. (Pubitemid 34267417)
4. Esposito K, Nappo F, Giugliano F, et al. Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr. 2003;77:139-143. (Pubitemid 36015383)
5. Bae JH, Bassenge E, Kim KB, et al. Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis. 2001;155:517-523. (Pubitemid 32209324)
6. Schinkovitz A, Dittrich P, Wascher TC. Effects of a high-fat meal on resistance vessel reactivity and on indicators of oxidative stress in healthy volunteers. Clin Physiol. 2001;21:404-410. (Pubitemid 32611278)
7. Tsai WC, Li YH, Lin CC, et al. Effects of oxidative stress on endothelial function after a high-fat meal. Clin Sci (Lond). 2004;106:315-319. (Pubitemid 38365839)
8. Signori LU, da Silva AMV, Plentz RDM, et al. Reduced venous endothelial responsiveness after oral lipid overload in healthy volunteers. Metabolism. 2008;57:103-109.
9. Frein D, Schildknecht S, Bachschmid M, et al. Redox regulation: a new challenge for pharmacology. Biochem Pharmacol. 2005;70:811-823. (Pubitemid 41138846)
10. Davidge ST. Prostaglandin H synthase and vascular function. Circ Res. 2001;89:650-660.
11. Stepniakowski KT, Lu G, Davda RK, et al. Fatty acids augment endothelium-dependent dilation in hand veins by a cyclooxygenase-dependent mechanism. Hypertension. 1997;30:1634-1639. (Pubitemid 27528116)
12. Haastrup A, Gadegbeku CA, Zhang D, et al. Lipids stimulate the production of 6-keto-prostaglandin F1a in human dorsal hand veins. Hypertension. 2001;38:858-863. (Pubitemid 34258683)
13. Bickerton AST, Roberts R, Fielding BA, et al. Preferential uptake of dietary fatty acids in adipose tissue and muscle in the postprandial period. Diabetes. 2007;56:168-176. (Pubitemid 46263106)
14. Rossi P, Andriesse GI, Oey PL, et al. Stomach distension increases efferent muscle sympathetic nerve activity and blood pressure in healthy humans. J Neurol Sci 1998;161:148-155. (Pubitemid 28559168)
15. Penev P, Spiegel K, Marcinkowski T, et al. Impact of carbohydrate-rich meals on plasma epinephrine levels: dysregulation with aging. J Clin Endocrinol Metab. 2005;90:6198-6206. (Pubitemid 41606544)
16. Zhao J, Qi R, Li R, et al. Protective effects of aspirin against oxidized LDL-induced inflammatory protein expression in human endothelial cells. J Cardiovasc Pharmacol. 2008;51:32-37.
17. Eisele G, Schwedhelm E, Schieffer B, et al. Acetylsalicylic acid inhibits monocyte adhesion to endothelial cells by an antioxidative mechanism. J Cardiovasc Pharmacol. 2004;43:514-521. (Pubitemid 39090017)
18. Hendry RG, Marshall JM. Vasoconstrictor products of cyclo-oxygenase activity limit acetylcholine-induced cutaneous vasodilatation in young men. Clinical Science. 2004;107:323-330.