Biodistribution study and identification of inflammatory sites using nanocapsules labeled with 99mTc-HMPAO

Nuclear Medicine Communications

Volumn 30, Issue 9, 2009, Pages 749-755

  Pereira, Maira A ^a   Mosqueira, Vanessa C F ^c   Carmo, Vildete A S ^a   Ferrari, Cristiano S ^b   Reis, Eduardo C O ^a   Ramaldes, Gilson A ^a   Cardoso, Valbert N ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b Ecograf Núcleo Diagnóstico ^*  (Brazil)

^c FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

Author keywords

Biodistribution; Hexametylpropyleneamine oxime; Inflammation; Nanocapsules; Scintigraphic images; Technetium 99m

Indexed keywords

CARRAGEENAN; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; NANOCAPSULE; TRACER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; DRUG DISTRIBUTION; HISTOPATHOLOGY; INFLAMMATION; ISOTOPE LABELING; MALE; NONHUMAN; RAT; SCINTILLATION;

ANIMALS; INFLAMMATION; ISOTOPE LABELING; MALE; NANOCAPSULES; RATS; RATS, WISTAR; TECHNETIUM TC 99M EXAMETAZIME; TISSUE DISTRIBUTION;

EID: 68249136841     PISSN: 01433636     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNM.0b013e32832f2b59     Document Type: Article

References (31)

1. Rennen HJJM, Boerman OC, Oyen WJG, Corstens FHM. Imaging infection/inflammation in the new millenium. Eur J Nucl Med 2001; 28:241-252.
2. Chianelli M, Mather SJ, Martin-Comin J, Signore A. Radiopharmaceuticals for the study of inflammatory processes: a review. Nucl Med Commun 1997; 18:437-455. (Pubitemid 27242838)
3. Boerman OC, Rennen H, Oyen WJG, Corstens FHM. Radiopharmaceuticals to image infection and inflammation. Semin Nucl Med 2001; 31:286-295.
4. Phillips WT, Rudolph AS, Goins B, Timmons JH, Klipper R, Blumhardt R. A simple method for producing a technetium-99m-labeled liposome which is stable in vivo. Nucl Med Biol 1992; 19:539-547.
5. Love C, Palestro CJ. Radionuclide imaging of infection. J Nucl Med Technol 2004; 32:47-57.
6. Corstens FHM, van der Meer JWM. Nuclear medicine's role in infection and inflammation. Lancet 1999; 354:765-770.
7. 99mTc-labeled LTB4 antagonist. J Nucl Med 2005; 46:1546-1551.
8. 99mTc by the hydrazino nicotinyl derivative. J Nucl Med 1999; 40:192-197.
9. Boerman OC, Laverman P, Oyen WJG, Corstens FHM, Storm G. Radio-labeled liposomes for scintigraphic imaging. Prog Lipid Res 2000; 39:461-475.
10. Dams ETM, OyenWJG, Boerman OC, Storm G, Laverman P, Kok PJM, et al. 99mTc-PEG liposomes for the scintigraphic detection of infection and inflammation: clinical evaluation. J Nucl Med 2000; 41:622-630. (Pubitemid 30207737)
11. Brouwers AH, De Jong DJ, Dams ETM, Oyen WJG, Boerman OC, Laverman P, et al. Tc-99m-PEG-Liposomes for the evaluation of colitis in Crohn's disease. J Drug Target 2000; 8:225-233.
12. Szebeni J, Baranyi L, Savay S, Bodo M, Morse DS, Basta M, et al. Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction. Am J Physiol Heart Circ Physiol 2000; 279:H1319-H1328.
13. Szebeni J, Baranyi L, Savay S, Milosevits J, Bunger R, Laverman P, et al. Role of complement activation in hypersensitivity reactions to Doxil and Hynic PEG liposomes: experimental and clinical studies. J Liposome Res 2002; 12:165-172. (Pubitemid 34846969)
14. Barratt G. Therapeutic applications of colloidal drug carriers. Pharm Sci Technol Today 2000; 3:163-171. (Pubitemid 30261519)
15. Mosqueira VCF, Legrand P, Barratt G. Surface-modified and conventional nanocapsules as novel formulation for parenteral delivery of halofanrine. J Nanosci Nanotechnol 2006; 9-10:3193-3202. (Pubitemid 44580000)
16. Sasatsu M, Onishi H, Machida Y. In vitro and in vivo characterization of nanoparticles made of MeO-PEG amine/PLA block copolymer and PLA. Int J Pharm 2006; 317:167-174.
17. Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R. Biodegradable long-circulation polymeric nanospheres. Science 1994; 263:1600-1603.
18. Mosqueira VCF, Legrand P, Gref R, Heurtault B, Appel M, Barrat G. Interactions between a macrophage cell line (J774A1) and surface-modified poly(D,L-lactide) nanocapsules bearing poly(ethylene glycol). J Drug Target 1999; 7:65-78. (Pubitemid 29484188)
19. Mosqueira VCF, Legrand P, Morgat J-P, Vert M, Mysiakine E, Gref R, et al. Biodistribution of long-circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density. Pharm Res 2001; 18:1411-1419. (Pubitemid 32977246)
20. Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 1989; 55:R1-R4. (Pubitemid 19247505)
21. Barthel H, Kampfer I, Seese A, Dannenberg C, Kluge R, Burchert W, et al. Improvement of brain SPECT by stabilization of Tc-99m-HMPAO with methylene blue or cobalt chloride. Nuklearmedizin 1999; 38:80-84.
22. Vinegar R, Truax JF, Selph JL, Johnston PR, Venable AL, Mckenzie KK. Pathway to carrageenan-induced inflammation in the hind limb of the rat. Fed Proc 1987; 46:118-126.
23. Pillai O, Panchagnula R. Polymers in drug delivery. Curr Opin Chem Biol 2001; 5:447-451.
24. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 2001; 70:1-20. (Pubitemid 32144788)
25. Yamaoka T, Tabata Y, Ikada Y. Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice. J Pharm Sci 1994; 83:601-606. (Pubitemid 24222392)
26. Mosqueira VCF, Legrand P, Gulik A, Bourdon O, Gref R, Labarre D, Barratt G. Relationship between complement activation, cellular uptake and physicochemical aspects of novel PEG-modified nanocapsules. Biomaterials 2001a; 22:2967-2979. (Pubitemid 32768704)
27. Schaffazick SR, Guterres SS, Freitas LL, Pohlmann AR. Characterization and physical and chemical stability of polymeric nanoparticle systems for administration of drugs. Química Nova 1999; 26:726-737.
28. Torchilin PV. Drug targeting. Eur J Pharm Sci 2000; 11 (Suppl 2):S81-S91.
29. Owens DE III, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 2006; 307:93-102. (Pubitemid 41773257)
30. Phillips WT. Delivery of gamma-imaging agents by liposomes. Adv Drug Delivery Rev 1999; 37:13-32.
31. Pereira MA, Mosqueira VCF, Vilela JMC, Andrade MS, Ramaldes GA, Cardoso VN. PLA-PEG nanocapsules radiolabeled with 99mTechnetium-HMPAO: release properties and physicalchemical characterization by atomic force microscopy and photon correlation spectroscopy. Eur J Nucl Med 2008; 33:47-57.