The Conserved NDR Kinase Orb6 Controls Polarized Cell Growth by Spatial Regulation of the Small GTPase Cdc42

Current Biology

Volumn 19, Issue 15, 2009, Pages 1314-1319

  Das, Maitreyi ^a   Wiley, David J ^a   Chen, Xi ^a   Shah, Kavita ^b   Verde, Fulvia ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

CELLBIO; CELLCYCLE; SIGNALING

Indexed keywords

CELL CYCLE PROTEIN; FOR3 PROTEIN, S POMBE; ORB6 PROTEIN, S POMBE; PROTEIN CDC42; PROTEIN SERINE THREONINE KINASE; SCHIZOSACCHAROMYCES POMBE PROTEIN;

ARTICLE; CELL ENLARGEMENT; CELL POLARITY; CYTOSKELETON; FLUORESCENCE MICROSCOPY; METABOLISM; PHYSIOLOGY; SCHIZOSACCHAROMYCES;

CDC42 GTP-BINDING PROTEIN, SACCHAROMYCES CEREVISIAE; CELL CYCLE PROTEINS; CELL ENLARGEMENT; CELL POLARITY; CYTOSKELETON; MICROSCOPY, FLUORESCENCE; PROTEIN-SERINE-THREONINE KINASES; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EUKARYOTA; SCHIZOSACCHAROMYCETACEAE;

EID: 68149181683     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2009.06.057     Document Type: Article

References (29)

1. Verde F., Mata J., and Nurse P. Fission yeast cell morphogenesis: Identification of new genes and analysis of their role during the cell cycle. J. Cell Biol. 131 (1995) 1529-1538
2. Verde F., Wiley D.J., and Nurse P. Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle. Proc. Natl. Acad. Sci. USA 95 (1998) 7526-7531
3. Zinn K. Dendritic tiling: New insights from genetics. Neuron 44 (2004) 211-213
4. Hergovich A., Stegert M.R., Schmitz D., and Hemmings B.A. NDR kinases regulate essential cell processes from yeast to humans. Nat. Rev. Mol. Cell Biol. 7 (2006) 253-264
5. Feierbach B., and Chang F. Roles of the fission yeast formin for3p in cell polarity, actin cable formation and symmetric cell division. Curr. Biol. 11 (2001) 1656-1665
6. Tatebe H., Shimada K., Uzawa S., Morigasaki S., and Shiozaki K. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Curr. Biol. 15 (2005) 1006-1015
7. Feierbach B., Verde F., and Chang F. Regulation of a formin complex by the microtubule plus end protein tea1p. J. Cell Biol. 165 (2004) 697-707
8. Martin S.G., McDonald W.H., Yates J.R., and Chang F. Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity. Dev. Cell 8 (2005) 479-491
9. Martin S.G., Rincon S.A., Basu R., Perez P., and Chang F. Regulation of the formin for3p by cdc42p and bud6p. Mol. Biol. Cell 18 (2007) 4155-4167
10. Rincon S., Coll P.M., and Perez P. Spatial regulation of Cdc42 during cytokinesis. Cell Cycle 6 (2007) 1687-1691
11. Coll P.M., Rincon S.A., Izquierdo R.A., and Perez P. Hob3p, the fission yeast ortholog of human BIN3, localizes Cdc42p to the division site and regulates cytokinesis. EMBO J. 26 (2007) 1865-1877
12. Etienne-Manneville S. Cdc42--the centre of polarity. J. Cell Sci. 117 (2004) 1291-1300
13. Tatebe H., Nakano K., Maximo R., and Shiozaki K. Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast. Curr. Biol. 18 (2008) 322-330
14. Hoffman G.R., and Cerione R.A. Flipping the switch: The structural basis for signaling through the CRIB motif. Cell 102 (2000) 403-406
15. Snell V., and Nurse P. Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth. EMBO J. 13 (1994) 2066-2074
16. Kanai M., Kume K., Miyahara K., Sakai K., Nakamura K., Leonhard K., Wiley D.J., Verde F., Toda T., and Hirata D. Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis. EMBO J. 24 (2005) 3012-3025
17. Leonhard K., and Nurse P. Ste20/GCK kinase Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle. J. Cell Sci. 118 (2005) 1033-1044
18. Hirata D., Kishimoto N., Suda M., Sogabe Y., Nakagawa S., Yoshida Y., Sakai K., Mizunuma M., Miyakawa T., Ishiguro J., et al. Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay. EMBO J. 21 (2002) 4863-4874
19. Merla A., and Johnson D.I. The Cdc42p GTPase is targeted to the site of cell division in the fission yeast Schizosaccharomyces pombe. Eur. J. Cell Biol. 79 (2000) 469-477
20. Coll P.M., Trillo Y., Ametzazurra A., and Perez P. Gef1p, a new guanine nucleotide exchange factor for Cdc42p, regulates polarity in Schizosaccharomyces pombe. Mol. Biol. Cell 14 (2003) 313-323
21. Murray J.M., and Johnson D.I. The Cdc42p GTPase and its regulators Nrf1p and Scd1p are involved in endocytic trafficking in the fission yeast Schizosaccharomyces pombe. J. Biol. Chem. 276 (2001) 3004-3009
22. Das M., Wiley D.J., Medina S., Vincent H.A., Larrea M., Oriolo A., and Verde F. Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p. Mol. Biol. Cell 18 (2007) 2090-2101
23. Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., et al. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 (2006) 841-847
24. Zallen J.A., Peckol E.L., Tobin D.M., and Bargmann C.I. Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Mol. Biol. Cell 11 (2000) 3177-3190
25. Stork O., Zhdanov A., Kudersky A., Yoshikawa T., Obata K., and Pape H.-C. Neuronal functions of the novel serine/threonine kinase Ndr2. J. Biol. Chem. 279 (2004) 45773-45781
26. Mazanka E., Alexander J., Yeh B.J., Charoenpong P., Lowery D.M., Yaffe M., and Weiss E.L. The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol. 6 (2008) e203
27. Hao Y., Chun A., Cheung K., Rashidi B., and Yang X. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J. Biol. Chem. 283 (2008) 5496-5509
28. Kurischko C., Kuravi V.K., Wannissorn N., Nazarov P.A., Husain M., Zhang C., Shokat K.M., McCaffery J.M., and Luca F.C. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol. Biol. Cell 19 (2008) 5559-5578
29. Govek E.-E., Newey S.E., and Van Aelst L. The role of the Rho GTPases in neuronal development. Genes Dev. 19 (2005) 1-49