Propylthiouracil induced anti-neutrophil cytoplasmic antibody-associated vasculitis with bone marrow plasmacytosis andgranulocytopenia

Chinese Medical Journal

Volumn 122, Issue 9, 2009, Pages 1112-1114

  Ozkok, Abdullah ^a   Salman, Serpil ^a   Agan, Mehmet ^a   Yavuz, A Selim ^a   Yarman, Sema ^a   Boztepe, Harika ^a   Alagol, Faruk ^a   Tanakol, Refik ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Anti neutrophil cytoplasmic antibody associated vasculitis; Granulocytopenia; Plasmacytosis; Propylthiouracil

Indexed keywords

ACETYLSALICYLIC ACID; C REACTIVE PROTEIN; LEVOTHYROXINE; LIOTHYRONINE; METHYLPREDNISOLONE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROPYLTHIOURACIL; RADIOACTIVE IODINE; THYROTROPIN; THYROTROPIN RECEPTOR ANTIBODY; THYROXINE;

ADULT; ANCA ASSOCIATED VASCULITIS; ANTIBODY DETECTION; APHTHOUS ULCER; ARTICLE; BONE MARROW; BONE MARROW BIOPSY; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE SEDIMENTATION RATE; EXOPHTHALMOS; FEMALE; FEVER; FOLLOW UP; GOITER; GRANULOCYTOPENIA; GRAVES DISEASE; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; LONG TERM CARE; LYMPHADENOPATHY; PLASMA CELL DYSCRASIA; PLASMACYTOSIS; PROTEIN BLOOD LEVEL; PUNCH BIOPSY; PURPURA; SKIN DEFECT; SPLENOMEGALY; TACHYCARDIA; THROMBOSIS; THYROID HORMONE BLOOD LEVEL;

ADULT; AGRANULOCYTOSIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; BONE MARROW DISEASES; FEMALE; GRAVES DISEASE; HUMANS; PLASMA CELLS; PROPYLTHIOURACIL; VASCULITIS;

EID: 68149180953     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.09.020     Document Type: Article

References (15)

1. Yamamoto A, Katayama Y, Tomiyama K, Hosoai H, Hirata F, Kimura F, et al. Methimazole-induced aplastic anemia caused by hypocellular bone marrow with plasmacytosis. Thyroid 2004; 14: 231-235.
2. Breier DV, Rendo P, Gonzalez J, Shilton G, Stivel M, Goldztein S. Massive plasmocytosis due to methimazole-induced bone marrow toxicity. Am J Hematol 2001; 67: 259-261.
3. Yarman S, Sandalci O, Tanakol R, Azizlerli H, Oguz H, Alagöl F. Propylthiouracil-induced cutaneous vasculitis. Int J Clin Pharmacol Ther 1997; 35: 282-286.
4. Cooper DS. Antithyroid drugs. N Engl J Med 2005; 352: 905-917.
5. Ansell JE. The blood in thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The thyroid. Philadelphia: PA Lippincott; 1996: 637-652.
6. Weitzman SA, Stossel TP. Drug-induced immunological neutropenia. Lancet 1978; 1: 1068-1072.
7. Hasegawa T, Bergh OJ, Terasaki PI, Graw RG. Occurrence of granulocyte cytotoxins and agglutinins. Transfusion 1975; 15: 226-230.
8. Wall JR, Fang SL, Kuroki T, Ingbar SH, Braverman LE. In vitro immunoreactivity to propylthiouracil, methimazole, and carbimazole in patients with Graves' disease: a possible cause of antithyroid drug-induced agranulocytosis. J Clin Endocrinol Metab 1984; 58: 868-872.
9. Sera N, Ashizawa K, Ando T, Abe Y, Ide A, Usa T, et al. Treatment with propylthiouracil is associated with appearance of antineutrophil cytoplasmic antibodies in some patients with Graves' disease. Thyroid 2000; 10: 595-599.
10. Akamizu T, Ozaki S, Hiratani H, Uesugi H, Sobajima J, Hataya Y, et al. Drug-induced neutropenia associated with anti-neutrophil cytoplasmic antibodies (ANCA): possible involvement of complement in granulocyte cytotoxicity. Clin Exp Immunol 2002; 127: 92-98.
11. Weetman AP. Non-thyroid autoantibodies in autoimmune thyroid disease. Best Pract Res Clin Endocrinol Metab 2005; 19: 17-32.
12. Aloush V, Litinsky I, Caspi D, Elkayam O. Propylthiouracil-induced autoimmune syndromes: two distinct clinical presentations with different course and managment. Semin Arthritis Rheum 2006; 36: 4-9.
13. Mathieu E, Fain O, Sitbon M, Thomas M. Systemic adverse effect of antithyroid drugs. Clin Rheumatol 1999; 18: 66-68.
14. Dhillon SS, Singh D, Doe N, Oadri AM, Ricciardi S, Schwarz MI. Diffuse alveolar hemorrhage and pulmonary capillaritis due to propylthiouracil. Chest 1999; 116: 1485-1488.
15. Winters MJ, Hurley RM, Lirenman DS. ANCA-positive glomerulonephritis and IgA nephropathy in a patient on propylthiouracil. Pediatr Nephrol 2002; 17: 257-260.