Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes

PLoS ONE

Volumn 4, Issue 7, 2009, Pages

  Hevezi, Peter ^a,b   Moyer, Bryan D ^a   Lu, Min ^a   Gao, Na ^a   White, Evan ^a,c   Echeverri, Fernando ^a   Kalabat, Dalia ^a   Soto, Hortensia ^a,d   Laita, Bianca ^a   Li, Cherry ^a   Yeh, Shaoyang Anthony ^a   Zoller, Mark ^a   Zlotnik, Albert ^a,b  

^a Senomyx Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BIOLEGEND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; BETA TUBULIN; CARBOXYPEPTIDASE; CXCL14 CHEMOKINE; DOUBLECORTIN; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 14; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR RECEPTOR; HYPOCALCIN; INTERLEUKIN 8; JANUS KINASE; KERATIN; MATRILYSIN; MEMBRANE PROTEIN; NEUREXIN; PHOSPHOLIPASE C BETA2; PHOSPHOLIPASE C DELTA; PHOSPHOLIPASE C DELTA4; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; THROMBOSPONDIN; THROMBOSPONDIN 4; TRANSFORMING GROWTH FACTOR BETA2; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; UBIQUITIN C; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; ZINC FINGER PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL REGENERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENETIC ASSOCIATION; GENETIC DATABASE; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNE SYSTEM; LASER CAPTURE MICRODISSECTION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMATE; SENSORY NERVE; STEM CELL; SYNAPTIC TRANSMISSION; TASTE BUD; ANIMAL; GENETICS; GENOME; METABOLISM; PHYSIOLOGY;

PRIMATES; RODENTIA;

ANIMALS; GENE EXPRESSION PROFILING; GENOME; PRIMATES; TASTE BUDS;

EID: 68149170549     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006395     Document Type: Article

References (74)

1. Kimura S (1992) Taste and nutrition. Nutr Rev 50: 427-433.
2. Ravasco P (2005) Aspects of taste and compliance in patients with cancer. Eur J Oncol Nurs 9 Suppl 2: S84-91.
3. Miura H, Kusakabe Y, Harada S (2006) Cell lineage and differentiation in taste buds. Arch Histol Cytol 69: 209-225.
4. Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2006) The receptors and cells for mammalian taste. Nature 444: 288-294.
5. Bachmanov AA, Beauchamp GK (2007) Taste receptor genes. Annu Rev Nutr 27: 389-414.
6. Gibbs RA, Rogers J, Katze MG, Bumgarner R, Weinstock GM, et al. (2007) Evolutionary and biomedical insights from the rhesus macaque genome. Science 316: 222-234.
7. Neira M, Danilova V, Hellekant G, Azen EA (2001) A new gene (rmSTG) specific for taste buds is found by laser capture microdissection. Mamm Genome 12: 60-66.
8. Suzuki Y, Mizoguchi I, Uchida N (2007) Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization. Arch Histol Cytol 70: 117-126.
9. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264.
10. Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, et al. (1999) Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci 2: 1055-1062.
11. Miyoshi MA, Abe K, Emori Y (2001) IP(3) receptor type 3 and PLCbeta2 are co-expressed with taste receptors T1R and T2R in rat taste bud cells. Chem Senses 26: 259-265.
12. Hall JM, Hooper JE, Finger TE (1999) Expression of sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouse. J Comp Neurol 406: 143-155.
13. Edgell CJ, BaSalamah MA, Marr HS (2004) Testican-1: a differentially expressed proteoglycan with protease inhibiting activities. Int Rev Cytol 236: 101-122.
14. Turner HC, Budak MT, Akinci MA, Wolosin JM (2007) Comparative analysis of human conjunctival and corneal epithelial gene expression with oligonucleotide microarrays. Invest Ophthalmol Vis Sci 48: 2050-2061.
15. Rodriguez S, Gaunt TR, Day IN (2007) Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease. Hum Genet 122: 1-21.
16. Nishioka M, Kohno T, Takahashi M, Niki T, Yamada T, et al. (2000) Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line. Oncogene 19: 6251-6260.
17. Kang GH, Lee S, Cho NY, Gandamihardja T, Long TI, et al. (2008) DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis. Lab Invest 88: 161-170.
18. Yang R, Crowley HH, Rock ME, Kinnamon JC (2000) Taste cells with synapses in rat circumvallate papillae display SNAP-25-like immunoreactivity. J Comp Neurol 424: 205-215.
19. Greengard P, Valtorta F, Czernik AJ, Benfenati F (1993) Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259: 780-785.
20. DeFazio RA, Dvoryanchikov G, Maruyama Y, Kim JW, Pereira E, et al. (2006) Separate populations of receptor cells and presynaptic cells in mouse taste buds. J Neurosci 26: 3971-3980.
21. Rizo J, Chen X, Arac D (2006) Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release. Trends Cell Biol 16: 339-350.
22. Takeda M, Suzuki Y, Obara N, Nagai Y (1992) Neural cell adhesion molecule of taste buds. J Electron Microsc (Tokyo) 41: 375-380.
23. Seta Y, Toyono T, Takeda S, Toyoshima K (1999) Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation. FEBS Lett 444: 43-46.
24. Miura H, Kusakabe Y, Kato H, Miura-Ohnuma J, Tagami M, et al. (2003) Co-expression pattern of Shh with Prox1 and that of Nkx2.2 with Mash1 in mouse taste bud. Gene Expr Patterns 3: 427-430.
25. Aruga J (2003) Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3. Gene Expr Patterns 3: 727-733.
26. Franco B, Guioli S, Pragliola A, Incerti B, Bardoni B, et al. (1991) A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules. Nature 353: 529-536.
27. Ebermann I, Walger M, Scholl HP, Charbel Issa P, Luke C, et al. (2007) Truncating mutation of the DFNB59 gene causes cochlear hearing impairment and central vestibular dysfunction. Hum Mutat 28: 571-577.
28. Orten DJ, Fischer SM, Sorensen JL, Radhakrishna U, Cremers CW, et al. (2008) Branchio-oto-renal syndrome (BOR): novel mutations in the EYA1 gene, and a review of the mutational genetics of BOR. Hum Mutat 29: 537-544.
29. Anderson SL, Coli R, Daly IW, Kichula EA, Rork MJ, et al. (2001) Familial dysautonomia is caused by mutations of the IKAP gene. Am J Hum Genet 68: 753-758.
30. Slaugenhaupt SA, Blumenfeld A, Gill SP, Leyne M, Mull J, et al. (2001) Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia. Am J Hum Genet 68: 598-605.
31. Smith A, Farbman A, Dancis J (1965) Absence of Taste-Bud Papillae in Familial Dysautonomia. Science 147: 1040-1041.
32. Pearson J, Finegold MJ, Budzilovich G (1970) The tongue and taste in familial dysautonomia. Pediatrics 45: 739-745.
33. Beidler LM, Smallman RL (1965) Renewal of cells within taste buds. J Cell Biol 27: 263-272.
34. Farbman AI (1980) Renewal of taste bud cells in rat circumvallate papillae. Cell Tissue Kinet 13: 349-357.
35. Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, et al. (2007) Changes in gene expression in beta cells after islet isolation and transplantation using lasercapture microdissection. Diabetologia 50: 334-342.
36. Esposito G (2007) Complementary techniques: laser capture microdissection-increasing specificity of gene expression profiling of cancer specimens. Adv Exp Med Biol 593: 54-65.
37. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, et al. (2000) A novel family of mammalian taste receptors. Cell 100: 693-702.
38. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, et al. (2001) Mammalian sweet taste receptors. Cell 106: 381-390.
39. LopezJimenez ND, Sainz E, Cavenagh MM, Cruz-Ithier MA, Blackwood CA, et al. (2005) Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells. Genomics 85: 472-482.
40. Xu H, Delling M, Li L, Dong X, Clapham DE (2007) Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A 104: 18321-18326.
41. Zhou Y, Liu HX, Mistretta CM (2006) Bone morphogenetic proteins and noggin: inhibiting and inducing fungiform taste papilla development. Dev Biol 297: 198-213.
42. Krimm RF (2007) Factors that regulate embryonic gustatory development. BMC Neurosci 8 Suppl 3: S4.
43. Yen TH, Wright NA (2006) The gastrointestinal tract stem cell niche. Stem Cell Rev 2: 203-212.
44. Iwatsuki K, Liu HX, Gronder A, Singer MA, Lane TF, et al. (2007) Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A 104: 2253-2258.
45. Liu HX, Maccallum DK, Edwards C, Gaffield W, Mistretta CM (2004) Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development. Dev Biol 276: 280-300.
46. Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R (2005) Normal and oncogenic forms of the receptor tyrosine kinase kit. Stem Cells 23: 16-43.
47. McLaughlin SK (2000) Erb and c-Kit receptors have distinctive patterns of expression in adult and developing taste papillae and taste buds. J Neurosci 20: 5679-5688.
48. Adams VR, Leggas M (2007) Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors. Clin Ther 29: 1338-1353.
49. Goodman VL, Rock EP, Dagher R, Ramchandani RP, Abraham S, et al. (2007) Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma. Clin Cancer Res 13: 1367-1373.
50. Johansen LD, Naumanen T, Knudsen A, Westerlund N, Gromova I, et al. (2008) IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci 121: 854-864.
51. Rahl PB, Chen CZ, Collins RN (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 17: 841-853.
52. Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, et al. (2001) Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95. J Biol Chem 276: 9174-9181.
53. Goldberg JL, Vargas ME, Wang JT, Mandemakers W, Oster SF, et al. (2004) An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells. J Neurosci 24: 4989-4999.
54. Uetani N, Chagnon MJ, Kennedy TE, Iwakura Y, Tremblay ML (2006) Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. J Neurosci 26: 5872-5880.
55. Horvat-Brocker A, Reinhard J, Illes S, Paech T, Zoidl G, et al. (2008) Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina. Neuroscience 152: 618-645.
56. Kim EJ, Battiste J, Nakagawa Y, Johnson JE (2008) Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Mol Cell Neurosci 38: 595-606.
57. Nakayama A, Miura H, Shindo Y, Kusakabe Y, Tomonari H, et al. (2008) Expression of the basal cell markers of taste buds in the anterior tongue and soft palate of the mouse embryo. J Comp Neurol 509: 211-224.
58. Hromas R, Broxmeyer HE, Kim C, Nakshatri H, Christopherson K 2nd, et al. (1999) Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. Biochem Biophys Res Commun 255: 703-706.
59. Shellenberger TD, Wang M, Gujrati M, Jayakumar A, Strieter RM, et al. (2004) BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. Cancer Res 64: 8262-8270.
60. Meuter S, Schaerli P, Roos RS, Brandau O, Bosl MR, et al. (2007) Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues. Mol Cell Biol 27: 983-992.
61. Wright DE (1968) The differential leucocyte count of human saliva. Arch Oral Biol 13: 1159-1161.
62. Kolodziej A, Schulz S, Guyon A, Wu DF, Pfeiffer M, et al. (2008) Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus. J Neurosci 28: 4488-4500.
63. Schonemeier B, Kolodziej A, Schulz S, Jacobs S, Hoellt V, et al. (2008) Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain. J Comp Neurol 510: 207-220.
64. Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, et al. (2007) Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J Biol Chem 282: 30794-30803.
65. Wang H, Zhou M, Brand J, Huang L (2007) Inflammation activates the interferon signaling pathways in taste bud cells. J Neurosci 27: 10703-10713.
66. Tonosaki K, Hori Y, Shimizu Y, Tonosaki K (2007) Relationships between insulin release and taste. Biomed Res 28: 79-83.
67. Just T, Pau HW, Engel U, Hummel T (2008) Cephalic phase insulin release in healthy humans after taste stimulation? Appetite 51: 622-627.
68. Power ML, Schulkin J (2008) Anticipatory physiological regulation in feeding biology: cephalic phase responses. Appetite 50: 194-206.
69. Adan RA, Tiesjema B, Hillebrand JJ, la Fleur SE, Kas MJ, et al. (2006) The MC4 receptor and control of appetite. Br J Pharmacol 149: 815-827.
70. Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, et al. (2008) Modulation of taste sensitivity by GLP-1 signaling. J Neurochem 106: 455-463.
71. Schiffman SS (1997) Taste and smell losses in normal aging and disease. Jama 278: 1357-1362.
72. Sandow PL, Hejrat-Yazdi M, Heft MW (2006) Taste loss and recovery following radiation therapy. J Dent Res 85: 608-611.
73. Bernhardson BM, Tishelman C, Rutqvist LE (2008) Self-reported taste and smell changes during cancer chemotherapy. Support Care Cancer 16: 275-283.
74. Braissant O, Wahli W (1998) A simplified in situ hybridization protocol using non-radioactively labeled probes to detect abundant and rare mRNAs on tissue sections. Biochemica 1: 10-16.