Minocycline-induced skin pigmentation: An update

Acta Dermatovenerologica Croatica

Volumn 17, Issue 2, 2009, Pages 123-126

  Geria, Aanand N ^a   Tajirian, Ani L ^a   Kihiczak, George ^a   Schwartz, Robert A ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Acne; Adverse drug reaction; Blue grey pigmentation; Hyperpigmentaton; Minocycline; Muddy brown pigmentation; Quinine iminium ion; Rosacea

Indexed keywords

AMITRIPTYLINE; DOXYCYCLINE; ESTROGEN; IRON; MELANIN; MINOCYCLINE; PHENOTHIAZINE DERIVATIVE; SUNSCREEN; TETRACYCLINE;

ACNE; ACNE VULGARIS; ATOPIC DERMATITIS; DERMIS; DRUG WITHDRAWAL; FACE; FOREARM; HISTOPATHOLOGY; HUMAN; INFECTION; KERATINOCYTE; LASER; LONG TERM CARE; MACROPHAGE; PATHOGENESIS; REVIEW; SIDE EFFECT; SIDEROSIS; SKIN INFLAMMATION; SKIN INJURY; SKIN PIGMENTATION; SKIN SCAR; STAINING; SUN EXPOSURE; SUNLIGHT; TREATMENT DURATION;

ACNE VULGARIS; ANTI-BACTERIAL AGENTS; HUMANS; HYPERPIGMENTATION; MINOCYCLINE;

EID: 68149167632     PISSN: 1330027X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. Fenske NA, Millns JL. Cutaneous pigmentation due to minocycline hydrochloride. J Am Acad Dermatol 1980;3:308-10.
2. Rahman Z, Lazova R, Antaya RJ. Minocycline hyperpigmentation isolated to the subcutaneous fat. J Cutan Pathol 2005;32:516-9.
3. Ban M, Kitajima Y. Nail discoloration occurring after 8 weeks of minocycline therapy. J Dermatol 2007;34:699-701.
4. Sanchez AR, Rogers RS, 3rd, Sheridan PJ. Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity. Int J Dermatol 2004;43:709-15.
5. McAllum P, Slomovic A. Scleral and conjunctival pigmentation following minocycline therapy. Can J Ophthalmol 2007;42:626-7.
6. Brown RJ, Rother KI, Artman H, Mercurio MG, Wang R, Looney RJ, et al. Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae. Arch Dermatol 2009;145:63-6.
7. Eshki M, Allanore L, Musette P, Milpied B, Grange A, Guillaume JC, et al. Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. Arch Dermatol 2009;145:67-72.
8. Shapiro LE, Knowles SR, Shear NH. Comparative safety of tetracycline, minocycline, and doxycycline. Arch Dermatol 1997;133:1224-30.
9. Argenyi ZB, Finelli L, Bergfeld WF, Tuthill RJ, McMahon JT, Ratz JL, et al. Minocycline-related cutaneous hyperpigmentation as demonstrated by light microscopy, electron microscopy and x-ray energy spectroscopy. J Cutan Pathol 1987;14:176-80.
10. Schofield JK, Tatnall FM. Minocycline induced skin pigmentation. Br J Gen Pract 1993;43:173-4.
11. Mouton RW, Jordaan HF, Schneider JW. A new type of minocycline-induced cutaneous hyperpigmentation. Clin Exp Dermatol 2004;29:8-14.
12. Goulden V, Glass D, Cunliffe WJ. Safety of long-term high-dose minocycline in the treatment of acne. Br J Dermatol 1996;134:693-5.
13. Dwyer CM, Cuddihy AM, Kerr RE, Chapman RS, Allam BF. Skin pigmentation due to minocycline treatment of facial dermatoses. Br J Dermatol 1993;129:158-62.
14. Layton AM, Cunliffe WJ. Minocycline induced pigmentation in the treatment of acne - a review and personal observations J Dermatol Treatment 1989;1:9-12.
15. Mehrany K, Kist JM, Ahmed DD, Gibson LE. Minocycline-induced cutaneous pigmentation. Int J Dermatol 2003;42:551-2.
16. Izikson L, Anderson RR. Resolution of blue minocycline pigmentation of the face after fractional photothermolysis. Lasers Surg Med 2008;40:399-401.
17. Eisen D, Hakim MD. Minocycline-induced pigmentation. Incidence, prevention and management. Drug Saf 1998;18:431-40.
18. Green D, Friedman KJ. Treatment of minocycline-induced cutaneous pigmentation with the Q-switched Alexandrite laser and a review of the literature. J Am Acad Dermatol 2001;44:342-7.
19. Bowen AR, McCalmont TH. The histopathology of subcutaneous minocycline pigmentation. J Am Acad Dermatol 2007;57:836-9.
20. Barza M, Brown RB, Shanks C, Gamble C, Weinstein L. Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs. Antimicrob Agents Chemother 1975;8:713-20.
21. Sato S, Murphy GF, Bernhard JD, Mihm MC Jr, Fitzpatrick TB. Ultrastructural and x-ray microanalytical observations of minocyclinerelated hyperpigmentation of the skin. J Invest Dermatol 1981;77:264-71.
22. Okada N, Sato S, Sasou T, Aoyama M, Nishida K, Yoshikawa K. Characterization of pigmented granules in minocycline-induced cutaneous pigmentation: observations using fluorescence microscopy and high-performance liquid chromatography. Br J Dermatol 1993;129:403-7.
23. Knowles SR, Shapiro L, Shear NH. Serious adverse reactions induced by minocycline. Report of 13 patients and review of the literature. Arch Dermatol 1996;132:934-9.
24. Shapiro LE, Uetrecht J, Shear NH. Minocycline, perinuclear antineutrophilic cytoplasmic antibody, and pigment: the biochemical basis. J Am Acad Dermatol 2001;45:787-9.
25. Knowles SR, Uetrecht J, Shear NH. Idiosyncratic drug reactions: the reactive metabolite syndromes. Lancet 2000;356:1587-91.
26. Nakamura S, Yokozeki H, Nishioka K. Acute pigmentation due to minocycline therapy in atopic dermatitis. Br J Dermatol 2003;148:1073-4.
27. Eedy DJ, Burrows D. Minocycline-induced pigmentation occurring in two sisters. Clin Exp Dermatol 1991;16:55-7.
28. Tsao H, Busam K, Barnhill RL, Dover JS. Treatment of minocycline-induced hyperpigmentation with the Q-switched ruby laser. Arch Dermatol 1996;132:1250-1.
29. Greve B, Schonermark MP, Raulin C. Minocycline-induced hyperpigmentation: treatment with the Q-switched Nd:YAG laser. Lasers Surg Med 1998;22:223-7.