Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 4, 2009, Pages 733-740

  Hingorani, Pooja ^a   Zhang, Wendong ^b   Piperdi, Sajida ^b   Pressman, Leyna ^b   Lin, Juan ^b   Gorlick, Richard ^b   Kolb, E Anders ^c  

^a PHOENIX CHILDREN'S HOSPITAL   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

Author keywords

IPM; Isophosphoramide mustard; Oxazaphosphorine; Palifosfamide lysine; Pediatric sarcomas

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; OXAZAPHOSPHORINE DERIVATIVE; PALIFOSFAMIDE LYSINE; UNCLASSIFIED DRUG; ZIO 210;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CHILDHOOD CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; ENZYME ASSAY; EVENT FREE SURVIVAL; EWING SARCOMA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MAXIMUM TOLERATED DOSE; MOUSE; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SARCOMA CELL; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; DNA PRIMERS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION; HUMANS; IFOSFAMIDE; LYSINE; MICE; MICE, SCID; OSTEOSARCOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 68149160212     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0922-4     Document Type: Article

References (14)

1. J Zhang Q Tian S Yung Chan S Cheun Li S Zhou W Duan YZ Zhu 2004 Metabolism and transport of oxazaphosphorines and the clinical implications Drug Metab Rev 37 611 703
2. NE Sladek R Kollander L Sreerama DT Kiang 2002 Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide- based chemotherapy of breast cancer: a retrospective study Cancer Chemother Pharmacol 49 309 321
3. L Sreerama NE Sladek 2001 Primary breast tumor levels of suspected molecular determinants of cellular sensitivity to cyclophosphamide, ifosfamide, and certain other anticancer agents as predictors of paired metastatic tumor levels of these determinants. Rational individualization of cancer chemotherapeutic regimens Cancer Chemother Pharmacol 47 255 262 (Pubitemid 32640761)
4. JS Moreb D Muhoczy B Ostmark JR Zucali 2007 RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide Cancer Chemother Pharmacol 59 127 136
5. RF Struck RL Davis Jr MD Berardini EL Loechler 2000 DNA guanine-guanine crosslinking sequence specificity of isophosphoramide mustard, the alkylating metabolite of the clinical antitumor agent ifosfamide Cancer Chemother Pharmacol 45 59 62
6. N Germann S Urien AH Rodgers M Ratterree RF Struck WR Waud DG Serota G Bastian BS Jursic LR Morgan 2005 Comparative preclinical toxicology and pharmacology of isophosphoramide mustard, the active metabolite of ifosfamide Cancer Chemother Pharmacol 55 143 151
7. PJ Houghton CL Morton C Tucker R Gorlick EA Kolb W Zhang MA Smith 2007 The Pediatric Preclinical Testing Program: description of models and early testing results Pediatr Blood Cancer 49 928 940
8. JS Moreb A Gabr GR Vartikar S Gowda JR Zucali D Mohuczy 2005 Retinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde J Pharmacol Exp Ther 312 339 345
9. L Sreerama NE Sladek 1997 Cellular levels of class 1 and class 3 aldehyde dehydrogenases and certain other drug metabolizing enzymes in human breast malignancies Clin Cancer Res 3 1901 1914
10. GK Rekha L Sreerama NE Sladek 1994 Intrinsic cellular resistance to oxazaphosphorines exhibited by a human colon carcinoma cell line expressing relatively large amounts of a class 3 aldehyde dehydrogenase Biochem Pharmacol 48 1943 1952
11. HS Friedman M Colvin SH Kaufmann SM Ludeman N Bullock DD Bigner OW Griffith 1992 Cyclophosphamide resistance in medulloblastoma Cancer Res 52 5373 5378
12. J Zhang Q Tian YZ Zhu AL Xu SF Zhou 2006 Reversal of resistance to oxazaphosphorines Curr Cancer Drug Targets 6 385 407
13. J Zhang Q Tian SY Chan W Duan S Zhou 2005 Insights into oxazaphosphorine resistance and possible approaches to its circumvention Drug Resist Updat 8 271 297
14. R Gale A Van Vugt L Rosen L Chang P Lorusso M Valdivieso L Malburg R Struck L Morgan 2006 Phase-1 study of isophosphoramide (IPM)-lysine in advanced cancers ASCO Annu Meet Proc 24 9524