MTT assays can underestimate cell numbers

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 4, 2009, Pages 861-862

  Liu, Wai M ^a   Dalgleish, Angus G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; FORMAZAN; IMATINIB; MITOCHONDRIAL ENZYME; OXIDOREDUCTASE; THYMIDINE;

APOPTOSIS; CANCER CELL; CELL ADHESION; CELL ASSAY; CELL COUNT; CELL FUNCTION; CELL PROLIFERATION; CELL VIABILITY; COLORIMETRY; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG EFFECT; HIGH THROUGHPUT SCREENING; HUMIDIFIER; IN VITRO STUDY; INCUBATION TEMPERATURE; LETTER; MITOCHONDRION; PRIORITY JOURNAL; SOLID TUMOR;

CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; TETRAZOLIUM SALTS;

EID: 68149157512     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1047-0     Document Type: Letter

References (3)

1. T Mosmann 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1-2 55 63
2. JT Sims R Plattner 2009 MTT assays cannot be utilized to study the effects of STI571/Gleevec on the viability of solid tumor cell lines Cancer Chemother Pharmacol 64 3 629 633
3. WM Liu LA Stimson SP Joel 2002 The in vitro activity of the tyrosine kinase inhibitor STI571 in BCR-ABL positive chronic myeloid leukaemia cells: synergistic interactions with anti-leukaemic agents Br J Cancer 86 9 1472 1478