Reduced somatosensory cortical activation in experimental models of neuropathic fecal incontinence

Diseases of the Colon and Rectum

Volumn 52, Issue 8, 2009, Pages 1417-1422

  Peirce, Colin ^a   Healy, Ciaran F ^a   O'Herlihy, Colm ^a,b   O'Connell, P Ronan ^a,c   Jones, James F X ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b NATIONAL MATERNITY HOSPITAL   (Ireland)

^c ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Animal model; Fecal incontinence; Pudendal nerve injury; Somatosensory evoked cortical potential

Indexed keywords

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EVOKED SOMATOSENSORY RESPONSE; FECES INCONTINENCE; FEMALE; HUMAN; NERVE CRUSH; NERVE FIBER; NERVE INJURY; NEUROPATHY; NONHUMAN; RAT; SOMATOSENSORY CORTEX; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; INNERVATION; PATHOLOGY; PATHOPHYSIOLOGY; PERIPHERAL NEUROPATHY; PHYSIOLOGY; RECTUM; SENSORY NERVE CELL; WISTAR RAT;

ANIMALS; AXONS; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS, SOMATOSENSORY; FECAL INCONTINENCE; FEMALE; NEURONS, AFFERENT; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; RECTUM; SOMATOSENSORY CORTEX;

EID: 68149148720     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/DCR.0b013e3181ab81fe     Document Type: Article

References (30)

1. Macmillan AK, Merrie AE, Marshall RJ, Parry BR. The prevalence of fecal incontinence in community-dwelling adults: a systematic review of the literature. Dis Colon Rectum 2004;47: 1341-1349
2. Mellgren A, Jensen LL, Zetterström JP, Wong WD, Hofmeister JH, Lowry AC. Long-term cost of fecal incontinence secondary to obstetric injuries. Dis Colon Rectum 1999;42:857-865
3. Donnelly V, Fynes M, Campbell D, Johnson H, O'Connell PR, O'Herlihy C. Obstetric events leading to anal sphincter damage. Obstet Gynecol 1998;92:955-961
4. Snooks SJ, Swash M, Setchell M, Henry MM. Injury to innervation of pelvic floor and sphincter musculature in childbirth. Lancet 1984;2:546-550
5. Snooks SJ, Henry MM, Swash M. Faecal incontinence due to external anal sphincter division in childbirth is associated with damage to the innervation of the pelvic floor musculature: a double pathology. Br J Obstet Gynecol 1985;92:824-828
6. Snooks SJ, Swash M, Mathers SE, Henry MM. Effect of vaginal delivery on the pelvic floor: a 5-year follow-up. Br J Surg 1990; 77:1358-1360
7. Fynes M, Donnelly V, O'Connell PR, O'Herlihy C. The effect of second vaginal delivery on anal sphincter function and faecal continence: a prospective study. Lancet 1999;354:983-986
8. Dudding TC, Vaizey CJ, Kamm MA. Obstetric anal sphincter injury: incidence, risk factors, and management. Ann Surg 2008; 247:224-237
9. Fitzpatrick M, O'Brien C, O'Connell PR, O'Herlihy C. Patterns of abnormal pudendal nerve function associated with postpartum faecal incontinence. Am J Obstet Gynecol 2003;189:730-735
10. Kerns JM, Damaser MS, Kane JM, et al. Effects of pudendal nerve injury in the female rat. Neurourol Urodyn 2000;19: 53-69.
11. Sakamoto K, Smith GM, Storer PD, Jones KJ, Damaser MS. Neuroregeneration and voiding behaviour patterns after pudendal nerve crush in female rats. Neurourol Urodyn 2000;19: 311-321
12. Damaser MS, Broxton-King C, Ferguson C, Kim FJ, Kerns JM. Functional and neuroanatomical effects of vaginal distention and pudendal nerve crush in the female rat. J Urol 2003;170: 1027-1031
13. Healy CF, O'Herlihy C, O'Brien C, O'Connell PR, Jones JF. Experimental models of neuropathic faecal incontinence. Dis Colon Rectum 2008;51:1619-1626
14. Wai CY, Miller RT, Word RA. Effect of prolonged vaginal distention and sphincter transection on physiologic function of the external anal sphincter in an animal model. Obstet Gynecol 2008;111:332-340
15. Sultan AH, Kamm MA, Hudson CN, Thomas JM, Bartram CI. Anal sphincter disruption during vaginal delivery. N Engl J Med 1993;329:1905-1911
16. Sultan AH, Kamm MA. Faecal incontinence after childbirth. Br J Obstet Gynaecol 1997;104:979-982
17. Matsushita M, Nakasato N, Nakagawam H, Kanno A, Kaiho Y, Arai Y. Primary somatosensory evoked magnetic fields elicited by sacral surface electrical stimulation. Neurosci Lett 2008;431: 77-80.
18. Sheldon R, Kiff ES, Clarke A, Harris ML, Hamdy S. Sacral nerve stimulation reduces corticoanal excitability in patients with faecal incontinence. Br J Surg 2005;92:1423-1431
19. Blok BF, Groen J, Bosch JL, Veltman DJ, Lammertsma AA. Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators. BJU Int 2006;98:1238-1243
20. Zhao S, Kim DH, Kline DG, Beuerman RW, Thompson HW. Somatosensory evoked potentials induced by stimulating a variable number of nerve fibers in rat. Muscle Nerve 1993;16: 1220-1227
21. Haghighi SS, Oro JJ, Gibbs SR, McFadden M. Effect of graded hypoxia on cortical and spinal somatosensory evoked potentials. Surg Neurol 1992;37:350-355
22. Lahti KM, Ferris CF, Li F, Sotak CH, King JA. Comparison of evoked cortical activity in conscious and propofol-anesthetized rats using functional MRI. Magn Reson Med 1999;41:412-416
23. Peirce C, Healy CF, O'Herlihy C, O'Connell PR, Jones JF. Effect of prolonged vaginal distention and sphincter transaction on physiologic function of the external anal sphincter in an animal model. Obstet Gynecol 2008;112:943-944
24. Fynes M, Marshall K, Cassidy M, et al. A prospective, randomized study comparing the effect of augmented biofeedback with sensory feedback alone on fecal trauma. Dis Colon Rectum 1999;42:753-758
25. Madoff RD. Surgical treatment options for fecal incontinence. Gastroenterology 2004;126:S48-54.
26. Matzel KE, Stadelmaier U, Hohenfellner M, Gall FP. Electrical stimulation of sacral spinal nerves for treatment of faecal incontinence. Lancet 1995;346:1124-1127
27. Kenefick NJ, Emmanuel A, Nicholls RJ, Kamm MA. Effect of sacral nerve stimulation on autonomic nerve function. Br J Surg 2003;90:1256-1260
28. Leng WW, Chancellor MB.Howsacral nerve stimulation works. Urol Clin N Am 2005;32:11-18
29. Fowler CJ. The perspective of a neurologist on treatment-related research in fecal and urinary incontinence. Gastroenterology 2004;126:S172-4.
30. Fowler CJ, Swinn MJ, Goodwin RJ, Oliver S, Craggs M. Studies of the latency of pelvic floor contraction during peripheral nerve evaluation show that the muscle response is reflexly mediated. J Urol 2000;163:881-883