Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)

BMC Microbiology

Volumn 9, Issue , 2009, Pages

  Li, Nan ^a   Wang, Fei ^b   Niu, Siqiang ^a   Cao, Ju ^a   Wu, Kaifeng ^a   Li, Youqiang ^a   Yin, Nanlin ^a   Zhang, Xuemei ^a   Zhu, Weiliang ^b   Yin, Yibing ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; ENZYME INHIBITOR; FURAN DERIVATIVE; IMIDAZOLE DERIVATIVE; PENICILLIN G; PROTEIN HISTIDINE KINASE; PROTEIN HISTIDINE KINASE VICK; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN-HISTIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; FEMALE; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMOCOCCAL INFECTION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEPSIS; SEQUENCE ALIGNMENT; STREPTOCOCCUS PNEUMONIAE; VERO CELL; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BIOLOGY; CERCOPITHECUS; CHEMICAL STRUCTURE; DRUG DEVELOPMENT; DRUG EFFECT; ENZYMOLOGY; METABOLISM; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); MUS; STREPTOCOCCUS PNEUMONIAE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CERCOPITHECUS AETHIOPS; COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; FEMALE; MALE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; SEPSIS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; VERO CELLS;

EID: 68149144249     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-9-129     Document Type: Article

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